Angiogenesis le Inhibitors ka Cancer Treatment
Tlhaloso: Angiogenesis
Angiogenesis e bua ka ho thehoa ha methapo e mecha ea mali 'meleng. Ke mokhoa o tloaelehileng oa 'mele oa phekolo empa o boetse oa phetha karolo ea ho hōla ha kankere.
Angiogenesis ho Health le Healing
Angiogenesis ke mokhoa o tloaelehileng o etsoang 'meleng ho sa tsotellehe boemo boo ho lona ho ntseng ho eketseha methapo ea mali e mecha.
Ka lebaka leo, ho hlokahala hore bana ba hōle, hobane lesela la uterine le ka hōla khoeli le khoeli ho basali ba pele, le bakeng sa maqeba ho folisa.
Angiogenesis ka Cancer le Metastasis
Angiogenesis e thahasella kankere hobane kankere e hloka hore ho thehoe methapo e mecha ea mali ho hōla le ho fokotsa matla. E le hore kankere e hōle e be e kholo ho feta millimeter (1 mm) angiogenesis e hloka ho etsahala. Cancer e etsa sena ka ho boloka lintho tse susumetsang angiogenesis, ka hona, kholo ea kankere.
Ntle le ho ba mokhoa o hlokahalang bakeng sa kankere ho hōla le ho hlasela lisele tse haufi, ho hlokahala hore metastasis e hlahe . E le hore lisele tsa kankere li tsamaee le ho theha lehae le lecha kae kapa kae ho feta moo li tsoang teng, lisele tsena li hloka ho tlisa methapo e mecha ea mali ho tšehetsa kholo ea libaka tsa bona tse ncha.
Angiogenesis le Vascular Endothelial Growth Factor (VEGF)
Lijana tsa mali li entsoe ka lisele tse bitsoang endothelial lisele tse ka har'a lijana.
Likokoana-hloko tse tsejoang e le li-vascular endothelial growth factors, VEGF ka nako e khutšoanyane, e sebetsa e le matšoao a etsang hore li-cellothe tsa endothelial li hōle le ho hlahisa methapo e mecha ea mali. Ka mantsoe a mang, ke li-activator. Sejana sa mali se thehoa 'meleng, joaloka mesebetsi e mengata, ke ho leka-lekana ho etsa liphetoho le ho thibela liphello.
Angiogenesis Inhibitors
Angiogenesis inhibitors ke mofuta oa litsela tsa phekolo , tse bolelang hore li tobane le lisele tsa kankere kapa lisele tse hlokahalang ho hōla kapa ho ata ha kankere.
Meriana ena e ka kena-kenana le ts'ebetso ea angiogenesis linthong tse 'maloa tse fapaneng. Tse ling tsa tsona ke thibelo ka ho khomarela motsoako oa li-vascular endothelial factor (VEGF) e le hore o se ke oa hlola o bonahatsa hore li-cellothe tsa endothelial li hōle, ka hona li emisa ho thehoa ha methapo ea mali e mecha.
Mehlala ea Angiogenesis Inhibitors
Tse ling tsa angiogenesis inhibitors tse fumanehang hona joale bakeng sa ho phekola kankere li kenyelletsa:
- Avastin (bevacizumab)
- Nexavar (sorafenib)
- Sutent (sunitinib)
- Bonyane (pazopanib)
- Afinitor (everolimus)
Ithute ho eketsehileng ka immunotherapy le kamoo angiogenesis inhibitors e sebetsang ho tšoara kankere.
Angiogenesis Inhibitors Plus Chemotherapy
Potso e tloaelehileng ke hore na ke hobane'ng ha batho ba tla hloka chemotherapy ho phaella ho angiogenesis inhibitors. Ho sheba tsela eo angiogenesis inhibitors e sebetsang ka eona e thusang ho hlalosa sena. Angiogenesis inhibitors ha e bolaee kankere, e mpa e sebetsa ho thibela ho hōla ho hoholo le ho jala (metastasizing), kahoo ho felisa hlahala, chemotherapy e lokela ho sebelisoa hammoho le angiogenesis inhibitors.
Litla-morao tsa Angiogenesis Inhibitors
Ha angiogenesis inhibitors li fumanoa ka lekhetlo la pele e le phekolo ea kankere, ho ne ho nahanoa hore ba tla ba le litla-morao tse seng kae.
Ho ne ho se joalo. Feela joalokaha chemotherapy e baka liphello tsa litla-morao ke liketso tsa lisele tse tloaelehileng (ka mohlala, ka ho emisa likarohano tsa seleng meleng ea moriri, mongobo le pampiri ea meno) angiogenesis inhibitors le tsona li ka baka litla-morao tse amanang le mosebetsi oa tsona lisele le lisele tse phetseng hantle. Tse ling tsa litla-morao tse tloaelehileng li amana le:
- Pholiso e mpe ea maqeba ho tloha ha angiogenesis inhibitors e sa sitise feela bokhoni ba lisele tsa kankere ho etsa methapo ea mali e mecha empa hape e kena-kenana le bokhoni ba lisele tse phetseng hantle ho etsa methapo e mecha ea mali ho nka sebaka sa kotsi.
- Ho koala meriana, e leng eona e ka lebisang litlhaselong tsa pelo le likoti.
- Khatello ea mali e phahameng.
Likamoso / Liteko tsa Kliniki
Meriana e mengata sehlopheng sena e ntse e hlahlojoa litekong tsa meriana, 'me ho na le tšepo ea hore ho hlasela kankere ka lebaka la ho kena-kenana le angiogenesis e tla ba karolo ea mekhoa e meng ea phekolo ea kankere nakong e tlang.
Lisebelisoa:
Mokhatlo oa American oa Clinic Oncology. Kankere.Net. Angiogenesis le Angiogenesis Inhibitors ho Phekola Kankere. 07/2014. http://www.cancer.net/navigating-cancer-care/how-cancer-treated/personalized-and-targeted-therapies/angiogenesis-and-angiogenesis-inhibitors-treat-cancer
National Cancer Institute. Angiogenesis Inhibitors. E ntlafalitsoe 10/07/11. https://www.cancer.gov/about-cancer/treatment/types/immunotherapy/angiogenesis-inhibitors-fact-sheet