Mokelikeli oa monoclonal ke eng? Likokoana-hloko tsa monoclonal li sebetsa joang kalafo ea ramatiki ea ramatiki? Ke efe lithethefatsi tsa biologic ke li-antibodies tse monoclonal? Na li ngata ho nts'etsopele?
Li-antibodies ke liprotheine tse hlahisoang ke tsamaiso ea 'mele ea ho itšireletsa mafung, haholo-holo lisele tse tšoeu tsa mali. Li potoloha maling ebe lia ama liprotheine tse tsoang linaheng tse ling tse bitsoang li-antigen e le hore li li senye kapa li se ke tsa li felisa.
Ka mohlala, ha u pepesehetse kokoana-hloko, 'mele oa hao o tla hlahisa li-antibodies ho thusa ho felisa tsamaiso ea hau ea tšoaetso.
Litlhare li fumaneha
Likokoana-hloko tsa monoclonal ke lintho tse hlahisoang ke laboratori tse ka fumanang le ho tlama limolek'hule tse itseng, tse kang tumor necrosis factor (TNF) , protheine e amehang ho bakang ho ruruha le ho senyeha ha ramatiki . Tse ling tsa TNF inhibitors ke liprotheine tse monoclonal.
- Remicade, e tsamaisoang ke ho kenngoa ha methapo ea pelo, e sebelisa motsoako oa liprotheine tsa batho le li-mouse ho etsa protheine e tsoekere e tsejoang e le chimeric monoclonal antibody.
- Humira, e tsamaisoang ka ente, e hlahisoa ke liprotheine tse feletseng tsa batho.
- Simponi ke motho ea bitsoang monoclonal antibody. E fumaneha e le ente kapa infusion.
Ho hlahisa liprotheine tse entsoeng ke batho ke mokhoa o rarahaneng o kenyelletsang ho kenya lisele tse ngata tse sa hloekeng tse tletseng limatlafatsi ho hlahisa liprotheine tse boletsoeng.
E hlahlojoa haholo ho netefatsa hore e hloekile pele e se e loketse ho sebelisa mokuli.
E 'ngoe ea protheine ea monoclonal e amoheloang bakeng sa phekolo ea ramatiki ea lefu la lefu ke Rituxan. Joaloka Remicade, ke mokelikeli oa monoclonal oa chimeric / mouse o fanoang ka ho kenngoa ha methapo. Ho fapana le Remicade, e hlasella lisele tsa B ho fapana le TNF.
Li-antibodies tse ngata tse ncha tsa monoclonal li le sethaleng sa tsoelo-pele ho phekola ramatiki ea mafu a mafura le maemo a mang.
Dr. Zashin ke moprofesa oa litsebi tsa bongaka lefapheng la Univesithi ea Texas Southwestern Medical le ngaka e eang Lefapheng la Lipetlele la Presbyterian ea Dallas le Plano. Dr. Zashin ke mongoli oa Arthritis ntle le bohloko - The Miracle Of TNF Blockers le co-mongoli oa Tlhaho ea Ramatiki ea Tlhaho .