Li-SASA li E 'ngoe ea Lithethefatsi Tse Ngata ka ho Fetisisa Tse Ngotsoeng
Li-NSAID (li-anti-inflammatory drug-inflammatory) li loantša ramatiki ka ho kena-kenana le ts'ebetso ea ho ruruha. Li-SASA ke sehlopha se seholo sa lithethefatsi tseo hangata li sebelisetsoang ho phekola ramatiki ka lebaka la tsona:
- li-analgesic (ho bolaea) thepa
- anti-inflammatory properties
- lithibela-mafu (ho fokotsa feberu)
NSAID Categories
Ho na le mefuta e meraro ea li-NSAID:
- salicylate (bobeli ba acetylated, tse kang aspirin , le tse sa hloekiselitsoeng)
- NSAID tsa setso
- COX-2 selective inhibitors
Li-SASA tse atisang ho sebelisoa bakeng sa ramatiki li kenyelletsa:
- E nchafatsoa (lebitso le tloaelehileng flurbiprofen)
- Arthrotec (lebitso le tloaelehileng la diclofenac le misoprostol)
- Aspirine (acetylsalicylic acid)
- Cataflam (lebitso le tloaelehileng la diclofenac potassium)
- Celebrex (lebitso le tloaelehileng la celecoxib)
- Clinoril (lebitso le tloaelehileng la sulindac)
- Daypro (li-oxaprozin tse tloaelehileng)
- Disalcid (lebitso le tloaelehileng la salsalate)
- Dolobid (lebitso le tloaelehileng la diflunisal)
- Feldene (e leng lebitso la piroxicam)
- Ibuprofen (mabitso a marang-rang a kenyelletsa Motrin, Advil, Mediprin, Nuprin, Motrin IB)
- Indocin (lebitso le tloaelehileng indomethacin)
- Ketoprofen (mabitso a marang-rang a kenyelletsa Orudis, Oruvail, Actron, Orudis KT)
- Lodine (lebitso le tloaelehileng la etodolac)
- Meclomen (lebitso le tloaelehileng la meclofenamate sodium)
- Mobic (lebitso le tloaelehileng la meloxicam)
- Nalfon (lebitso le tloaelehileng la fenoprofen)
- Naproxen (mabitso a mabitso a akarelletsa Naprosyn, Aleve, Naprelan, Anaprox)
- Ponstel (lebitso le tloaelehileng la mefenamic acid)
- Relafen (lebitso le tloaelehileng la nabumetone)
- Tolectin (lebitso la tloaelehileng tolmetin sodium)
- Trilisate (lebitso le tloaelehileng la choline magnesium trisalicylate)
- Voltaren (lebitso le tloaelehileng la diclofenac sodium)
Mesebetsi ea NSAID e sebetsa joang
Ka mantsoe a bonolo, li-NSAID li sebetsa ka ho fokotsa ho ruruha. Ba etsa sena ka ho thibela enzyme ea bohlokoa ea ho ruruha e bitsoang cyclooxygenase, e fetolelang arachidonic acid ho prostaglandins le leukotrienes.
Prostaglandins e baka ho ruruha ha sebaka. Ka hona, ka ho thibela cyclooxygenase, li-NSAID li fokotsa ho ruruha .
NSAID e ka 'na ea u tsoela molemo ho feta eo u neng ue lekile pele - kapa e ka' na ea se ke ea sebetsa ho hang. Ke ka lebaka la ho hong ho thoeng ke phapang ea pharmacokinetic - mokhoa oo lithethefatsi li kenngoa ka oona, li ajoa, li sebelisoa ka metsoli le ho felisoa.
E eketsehileng ka Cyclooxygenase ea Enzyme
Ho na le mefuta e 'meli ea cyclooxygenase, e tsejoang e le COX-1 le COX-2. COX-1 e ameha ho boloka moriana o nepahetseng oa mala le liphio. COX-2 ke enzyme e ikarabellang bakeng sa ho ruruha. Hobane li-NSAID tsa setso li thibela ka bobeli COX-1 le COX-2, li ka ba le litla-morao tse sa batleheng, tse kang ho halefa mala kapa ho fokotseha ha liphio. Ke kahoo bafuputsi ba nts'etsitseng NSAIDS e thibelang COX-2 feela. Li-COX-2 selective inhibitors ke sehlopha se secha ka ho fetisisa sa li-NSAID.
Likarolo tsa FDA bakeng sa NSAID Tsohle
Ka 2004, moetsi oa COX-2 selective inhibitor Vioxx ka boithatelo o ile ae tlosa 'marakeng ka mor'a lipatlisiso tse bontšitsoeng nako e telele li ka eketsa kotsi ea ho hlaseloa ke pelo le ho otloa ke lefu. Tlhahlobo e latelang ea US Administration and Drug Administration e ile ea lebisa tlhokomelong ea 2005 hore li-NSAID tsohle tse se nang aspirin li na le temoso e amanang le eona.
Ke habohlokoa ho bua ka likotsi tsena tse ka 'nang tsa e-ba teng le ngaka ea hau. (Kamora 'ona o tlohetse COX-2 inhibitor ka' marakeng - Celebrex.)
Katleho ea li-NSAID
- Ka linako tse ling bohloko le ho ruruha li etsahala mokhoeng o potolohang (letsatsi le leng le le leng la potoloho ho latela nako ea lihora tse 24). Ka hona, li-NSAID li ka atleha haholo linakong tse itseng.
- Batho ba ka bang 60% ba bakuli ba tla arabela NSAID leha e le efe e le 'ngoe. Nako ea liteko ea libeke tse tharo e lokela ho u lumella nako e lekaneng ea ho tseba hore na lithethefatsi li u sebeletsa. Ka bomalimabe, hoo e ka bang 10% ea bakuli ba ramatiki ba lefu la masapo ba tla fumana li-NSAID ha li sebetse bakeng sa bona.
- Li-SASA li ka pata matšoao a matšoao.
- Liphello tse mpe tsa li-NSAID tse ka etsoang ka nako leha e le efe li kenyelletsa ho hloleha ha liphio, ho se sebetse ha sebete, ho tsoa mali, le lesela la mpa.
- Li-NSAID (haholo-holo indomethacin) li ka kena-kenana le meriana e sebelisang ho laola khatello ea mali e matla le ho hloleha ha pelo (tse kang li-antagonist tsa beta-adrenergic, li-inhibitor tsa angiotensin) kapa li-diuretics).
- Liphuputso tse ling tsa lipatlisiso li bontša hore tšebeliso ea nako e telele ea NSAID e ka 'na ea potlakela ho lahleheloa ke lefu la khase, empa ho hlokahala lipatlisiso tse eketsehileng.
The Bottom Line
E ke ke ea bolela esale pele hore na NSAID e tla u sebeletsa ka ho fetisisa. Ha ho na NSAID e le 'ngoe e bontšitsoeng hore e phahametse ba bang bakeng sa liphallelo tsa bohloko. Hang ha NSAID e khethiloe, tekanyo e lokela ho eketseha ho fihlela bohloko bo kokobetsoa kapa ho fihlela tekanyo e mamelletseng e mamelitsoeng e fihlile. Karabo ea mokuli e lokela ho ba tataiso ea ho khetha tekanyo e nepahetseng, ho sebelisa tekanyo e tlaase ka ho fetisisa e ka fumanoang ho fumana phomolo ea bohloko. Kamehla buisana ka melemo le likotsi tse ka 'nang tsa e-ba teng ka li-NSAID le ngaka ea hau.
> Mehloli:
> Duke University Medical Centre Buka ea Ramatiki, David S. Pisetsky, MD, Ph.D. 1995.
> New England Journal of Medicine, 324 (24): 1716-1725, 1991