Epidermis ke karolo e ka ntle ea letlalo 'me e entsoe ka likarolo tse hlano. The stratum corneum ke karolo e ka holimo ho tse hlano mme e nka e le thibelo.
Pele ho bohareng ba lilemo tsa bo-1970, ho ne ho nkoa hore strneum corneum e na le inerolose ea lintho tse phelang, e kang letlapa le tšesaane la polasetiki le sireletsang letlalo le tlaase haholoanyane. Lilemong tse mashome a seng makae tse fetileng, bo-rasaense ba hlokometse hore ts'ebetso ea lik'hemik'hale le lik'hemik'hale tsa stratum corneum e hlile e thata ebile e rarahaneng.
Ho utloisisa sebopeho le ts'ebetso ea stratum corneum ke habohlokoa hobane ke senotlolo sa ho ba le letlalo le phetseng hantle le le letle. Lipapiso tsena li tla u isa likarolong tsa bohlokoa tsa stratum corneum.
The Corneocyte
The stratum corneum e na le mofuta oa "setene le seretse", 'me "litene" ka papiso ena ke liprotheine tse rarahaneng tse bitsoang corneocytes (bona papiso). Korneocyte e entsoe ka lisebelisoa tse nyane tsa keratine ka matrix a hlophisitsoeng. Keratin e ka boloka metsi a mangata pakeng tsa likhoele / likhoele. The stratum corneum e na le likarolo tse 12 ho isa ho tse 16 tsa corneocyte, 'me corneocyte e' ngoe le e 'ngoe e na le boima ba micrometer e le 1, ho itšetlehile ka lintlha tse latelang: lilemo, sebaka sa tlhaho le tlhahiso ea mahlaseli a kotsi a UV .
Lamellar Bodies
Li-lamellar li thehoa likeratinocytes tsa stratum spinosum le stratum granulosum. Ha keratinocyte e ntse e hōla ho e-na le stratum corneum, li-enzyme li senya enfelopo ea ka ntle ea 'mele ea linaleli, e lokolla mefuta ea lipids e bitsoang mahala mahala mafura le li-ceramide.
Intercellular Lipids
Mafura a mafura a mafura le li-ceramide tse lokolloa liphatleng tsa lebone li kopanya hammoho le stratum corneum ho theha sebaka se tsoelang pele sa lipids. Hobane ho na le mefuta e 'meli ea lipids, mocheso ona o bitsoa lamellar lipid bilayer. Le lipid bilayer e phetha karolo ea bohlokoa ho boloka thepa e thibelang letlalo 'me e tšoana le "seretse" litšoantšong tsa setene le seretse.
Enfelopo e entsoe
Khomo e 'ngoe le e' ngoe ea corneocyte e pota-potiloe ke sepolanka sa protheine e bitsoang cell envelope. Enfelopo ea sele e entsoe haholo-holo ka liprotheine tse peli, laoricrin le involucrin. Liprotheine tsena li na le maqhama a mangata pakeng tsa e mong, e leng ho etsa hore enfelopo ea sele e be sebopeho sa corneocyte. Mefuta e 'meli ea li-envelope tsa sele e hlalosoa e le "e thata" le "e tsitsitseng," e itšetlehile ka ho sebelisana ha lamellar lipid bilayer le enfelopo ea sele.
Enfelopo ea Enfelopo Lipids
Tse khomaretsoeng seleng ea enfelopo ke setho sa ceramide lipids se phefolang metsi. Kaha lamellar lipid bilayer e boetse e phekola metsi, limolek'hule tsa metsi li tšoaroa pakeng tsa sele ea enfelopo lipids le lipid bilayer. Sena se thusa ho boloka metsi a leka-lekaneng ka stratum corneum ka ho tšoasa limolek'hule tsa metsi, ho e-na le ho ba tlohella hore ba kenelle likarolong tse ka tlaase tsa epidermis.
Corneodesmosomes
"Litlhōlisano" tse tšoereng corneocyte hammoho ke liprotheine tse khethehileng tsa liprotheine tse bitsoang corneodesmosomes. Mehaho ena e boetse e le karolo ea "seretse" ka mokhoa o tšoanang oa "litene le seretse". Corneodesmosomes ke mekhoa e meholo e lokelang ho silafatsoa letlalong ho tšolloa ka mokhoa o bitsoang desquamation.
Sebopeho sa tlhaho sa tlhaho (NMF)
Motsoako oa tlhaho oa motsoako oa tlhaho (NMF) ke pokello ea metsoako ea metsi e qhibilihang ka metsi e fumanehang feela stratum corneum. Lik'hemik'hale tsena li na le karolo ea 20 ho isa ho 30 lekholong ea boima bo omileng ba corneocyte. Litho tsa NMF li noa metsi sepakapakeng ebe lia kopanya le metsi a tsona, li lumella likarolo tse ka thōko tsa stratum corneum ho lula li le metsi ho sa tsotellehe ho pepeseha hoa maemo. Hobane likarolo tsa NMF li qhibiliha metsing, li nolofalloa habonolo ho tloha lisele tse nang le ho kopana le metsi-ke ka lebaka leo ho ikopanya hangata le metsi ho etsang hore letlalo le senyehe. Mocheso oa lipid o potolohileng corneocyte o thusa ho tiisa corneocyte ho thibela tahlehelo ea NMF.
Tsamaiso ea ho qhaqha
Mokhoa oa ho ts'oaroa kapa oa ho tlosoa ha lifofane oa stratum corneum ha e le hantle o rarahane haholo mme likarolo tse ling tsa ts'ebetso ena li utloisisoa hantle. Hoa tsebahala hore mefuta e 'maloa ea li-enzyme e senya corneodesmosomes ka mokhoa o khethehileng, empa se nepahetseng hantle sa li-enzyme tsena kapa hore na li fetoha joang e le hore ho qale ho ts'oaroa ka mokhoa o sa tsejoeng. Metsi le pH li phetha karolo ea bohlokoa mosebetsing oa li-enzyme tsena.
> Mehloli:
> van Smeden J, Hoppel L, van der Heijden R, Hankemeier T, Vreeken RJ, Motlakase JA. Tlhaloso ea LC / MS ea stratum corneum lipids: profiling ea ceramide le ho sibolla. J Lipid Res . 2011 Jun; 52 (6): 1211-1221.
> Walters RM, Mao G, Gunn ET, Hornby S. Cleaning formulations e hlomphang thibelo ea letlalo. Dermatol Res Pract . 2012; 2012: 495917.
> Johnson, AW. (2015). Lisebelisuoa tsa Mafura: Mosebetsi le Letlalo la Letlalo. Mekhoa ea ho itšireletsa ka mahlahahlaha - Litho tsa mahlahahlaha . Ed. Zoe Diana Draelos. Elsevier, 11-17.
> Verdier-Sévrain S, Bonté F. Skin hydration: ho hlahloba mekhoa ea eona ea limolek'hule. J Cosmet Dermatol. 2007 Jun; 6 (2): 75-82.