Ithute Melemo ea Tlhahlobo ea Monoclonal Antibody
Monoclonal antibody therapy ke lefu la kankere le hlaselitsoeng . Ka linako tse ling e bitsoa immunotherapy. Le hoja ho buuoa , chemotherapy , le phekolo ea mahlaseli e ntse e le lits'ebetso tsa bohlokoa tsa phekolo ea kankere ea colone, phekolo ea monoclonal antibody e ntse e fumaneha haholoanyane bakeng sa ho sebelisoa. Mefuta e tloaelehileng ka ho fetisisa ea phekolo ea meriana ea monoclonal ea ho laola kankere ea colon ke Bevacizumab (Avastin), Cetuximab (Erbitux), le Panitumumab (Vectibix).
Li-antibodies tsa Monoclonal ke life?
Li-antibodies tsa monoclonal ke liprotheine tse entsoeng laboratori. Liprotheine tsena li etselitsoe hore li kopane le libaka tse holim'a lisele tsa kankere le ho kena-kenana le khōlo ea tsona le ho ata. Li-antibodies tsa monoclonal li tšoana le li-antibodies tseo 'mele oa hao o li hlahisang ha o pepeseha libaktheria kapa likokoana-hloko, tse kang serame kapa feberu (feberu).
Li-Antibodies Tsa Monoclonal li Sebetsa Joang?
Lisele tsa 'mele ea rona, ho akarelletsa lisele tsa kankere, li na le libaka tse holim'a tsona li bitsoang receptors. Li-receptors tsena li thusa ho laola hore na lisele tsa rona li hōla joang, li khaotsa ho hōla, kapa li etsa ntho leha e le efe ea lisele tse atisang ho li etsa. Haeba protheine e nepahetseng e fihla 'me e kopanya (e tlamisa) ho e fumanoang sele, sena se etsa hore sele e arabe.
Tsela e ntle ea ho nahana ka li-receptor le liprotheine tsa tsona tse tlamang ke ho nahana ka senotlolo le senotlolo. Lenaka le ke ke la bula ntle le senotlolo se nepahetseng. Ka mokhoa o ts'oanang, mokelikeli o ke ke oa etsa hore sele e hōle, e arohane, kapa e arabele ntle le haeba "senotlolo" se nepahetseng se amohelehang pele.
'Me li-antibodies tsa monoclonal ke "linotlolo" tse etselitsoeng ho ikamahanya le li-receptors ho lisele tsa kankere.
Mehlala ea Meriana ea Monoclonal Antibody
Li-epidermal growth factor receptors (EGFRs) ke mohlala o mong oa li-receptor tseo likokoana-hloko tsa monoclonal li li batlang. Li-EGFR li teng lisele tse tloaelehileng le lisele tsa kankere, empa ka lisele tsa kankere, li-receptor tsena ha lia tloaeleha.
Ho na le EGFR e mengata haholo kapa e ka senyeha kapa ea fetoloa (e fetotsoe) ka tsela e ba lumellang hore ba arabele ho feta lipontšo tsa kgolo. Sena se etsa hore lisele tsa kankere li hōle kapele kapa li hōle libakeng tseo li sa lokelang ho li hōla.
Litlhare tsa moriana oa monoclonal Cetuximab (Erbitux) le Panitumumab (Vectibix) li ikamahanya ka ho khetheha le li-EGFR tse fumanehang ka lisele tsa kankere. Ha li ikamahanya le li-EGFR, li thibela lipontšo tsa khōlo tseo 'mele oa hau o li hlahisang ho tloha liphateng tsa kankere. Sena se liehisa kapa se emisa ho hōla ha kankere.
Ho nahana ka senaka le papiso ea bohlokoa, u ka inahanela hore Cetuximab le Panitumumab ba sebetsa joalokaha eka motho o ne a khomarela mokoallo. Senotlolo se ke ke sa kenella 'me monyako o ke ke oa buloa hobane li-receptor tsa sele ea kankere li se li ntse li "kopantsoe" ke li-antibodies tsa monoclonal. Sena se bolela hore lisele tsa kankere ha li sa amohele matšoao a kgolo ao ba a hlokang ho tsoela pele ho hōla le ho hasana.
Likokoana-hloko tsa likokoana-hloko tsa Monoclonal
Ntle le ho fokotsa mesebetsi ea lisele tse nang le lithethefatsi, li-antibodies tsa monoclonal li ka kopanngoa le lithethefatsi tsa chemotherapy kapa li-radiacmotherapy (radioimmunotherapy) kahoo ba nka khato ea phekolo ea kankere eseng lisele tse tloaelehileng. Sena se sebelisoa ka mefuta e meng ea lymphoma le kankere ea matsoele le lithethefatsi li ka ba teng ho phekola mefuta e meng ea kankere.
Liphello Tse Ntle tsa Phekolo ea Meriana ea Monoclonal ke efe?
Bakeng sa batho ba bangata, litla-morao tsa monoclonal antibody therapy li matla ho feta chemotherapy 'me li tšoana le mofuta o mong oa phekolo. Tse ling tsa litla-morao tse tloaelehileng tsa monoclonal antibody therapy li kenyelletsa:
- Litlhaku tsa letlalo
- Ho hlatsoa letlalo kapa ho pata
- Matšoao a kang a feberu ea mafu a kang feberu, maqeba, mesifa ea mesifa, mokhathala le hlooho
- Letšollo
- Nosea le ho hlatsa
- Khaello ea mali
Batho ba bang ba na le tšusumetso e kholo ho phekolo ea monoclonal antibody. Litla-morao tse tebileng tse ka etsang hore ngaka ea hao e emise phekolo ea moriana oa monoclonal e kenyelletsa:
- Mali a tlase haholo
- Mathata a pelo ho kenyeletsa ho otloa ha pelo, ho hloleha ha pelo, le kotsi e eketsehileng ea lefu la pelo
- Maemong a tlase a magnesium, potasiamo kapa khalsiamo maling a hao, a ka bakang mathata a tebileng a bophelo bo botle
- Litlama tse tebileng tsa letlalo tse lebisang ho tšoaetso
- Mathata a ho pholla
- Liketso tse potlakileng ho infusion ho kenyelletsa ho fokola ha nakoana, ho tsuba, ho senyeha, ho fokotsa, ho ba le botenya, ho ponoa ke maikutlo, ho nyekeloa ke pelo, kapa bohloko ba sefuba kapa khatello
Ka lehlohonolo, ha liketsahalo tse tebileng li etsahala, li atisa ho etsahala hang-hang, ha u fumana meriana moo u leng tleliniking ea tlhokomelo ea kankere. Sena se bolela hore ngaka le mooki ba tla le hlahloba 'me ba tla khona ho emisa infusion haeba ho hlokahala le ho u fa tlhokomelo ea meriana hang-hang.
Nka Etsa'ng Hore ke Sebelise Monoclonal Antibody Treatment Side Effects?
Lintho tse peli tsa bohlokoa ka ho fetisisa tseo u ka li etsang ho laola litla-morao tsa monoclonal antibody therapy ke tse latelang:
- Nka meriana ea hau kaofela joalokaha e laetsoe, hobane ho bonolo ho thibela litla-morao ho feta ho li tšoara hang ha li etsahala.
- Boloka melaetsa ea puisano e bulehileng le sehlopha sa hau sa bongaka. Se sebetsang ho laola litla-morao ho motho a le mong se ka 'na sa se sebetse bakeng sa hau. Bua le ngaka kapa mooki ka mekhoa e tla u thusa ho kena kalafo ka litla-morao tse fokolang.
U se ke ua amohela maikutlo ao hampe ke karolo ea tlhaho ea phekolo ea kankere. Ho ka 'na ha e-ba le tsela ea hore sehlopha sa hau sa bongaka se sebetsane hantle le litla-morao tsa hau. Haeba u hloka thuso, e botse. Kamehla, haeba o e-na le lipotso ka litla-morao, bitsa sehlopha sa hau sa bongaka hang-hang.
Lisebelisoa
Fakih M. Anti-EGFR likokoana-hloko tsa monoclonal tse nang le kankere e khanyang ea metastatic: nako ea mokhoa o ikemetseng? Expert Rev Anticancer Ther 2008 8: 1471-80.
Medline Plus. Injection ea Bevacizumab.
https://medlineplus.gov/druginfo/meds/a607001.html
Medline Plus. Inuximab Injection.
https://medlineplus.gov/druginfo/meds/a607041.html
Medline Plus. Injection ea Panitumumab.
https://medlineplus.gov/druginfo/meds/a607066.html
Patel DK. Tšebeliso ea meriana ea ho loantšana le epidermal ho hōla lisele tsa monoclonal li-antibodies tse nang le kankere e khanyang. Pharmacotherapy 2008 28: 31S-41S.
Ramos FJ, Macarulla T, Capdevila J, Elez E, Tabernero J. Ho utloisisa karolo ea pele-pele ea K-ras bakeng sa li-epidermal ho hōla ka lebaka la ho phekoloa ha kankere. Clin Colorectal Cancer 2008 7: S52-S57.
American Cancer Society. Li-antibodies tsa monoclonal. E fihlile: Labo 4, 2015.
http://www.cancer.org/treatment/fateloang-hloko le lihlahisoa tsa lefutso / treatingtypes/immunotherapy/immunotherapy-monoclonal-antibodies