Ho na le thahasello e ntseng e eketseha tšebelisong ea nanotechnology le mekhoa e metle ea meriana. Lisebelisoa tse sa khoneng ho senya tse lekanyang matšoao a bohlokoa, hammoho le lisebelisoa tse sa sebeliseng tse etsang hore mekhoa e tsitsitseng e be e phutholohileng, joale e ea hohle. Sebaka se seng sa bohlokoa sa tsoelo-pele ea nanotechnology ke nts'etsopele ea nanoparticles e ka jarang meriana le lisele tse itseng tse itseng kapa lisele tse itseng.
Li-nron "tsa drones" tse nang le mefuta e meholo li na le matla a maholo libakeng tse sa tšoaneng tsa bongaka. Li se li ntse li kenngoa ka incology 'me li sebelisetsoa ho fokolisa lithethefatsi tsa selefouno ka mefuta ea mouse. Ka 2015, litsebi tsa lefu la pelo li boetse li sebelisoa ke nanotechnology ho fana ka lithethefatsi le ho lokisa methapo ea meriana , e leng mokhoa oa ho phekola lefu la matla a tšoaetso ea mali ka tsela e ncha, mohlomong ho thibela mafu a pelo le lipolao.
Ho sebelisa Nanotechnology ho rarolla ho ruruha
Phuputso ea liphoofolo tsa mefuta ea liphoofolo, e hatisitsoeng Scientific Translational Medicine , e tlalehile hore li-drones tsa nano-size li ka atleha ho tsosolosa letlapa la atherosclerotic, ho etsa hore lejoe le be le tsitsitseng 'me ho se ke ha e-ba le monyetla oa ho senya le ho fetoha lesela la mali le bolaeang. Bafuputsi ba tsoang Sekolong sa Bongaka sa Harvard, Brigham le Sepetlele sa Basali le Univesithing ea Columbia ba entse li-nanomedicines tse neng li entsoe hore li nke lintho tse khahlanong le ho ruruha ka ho toba setsing se hlalositsoeng.
Ho se rarolle ho ruruha ke ntho e ka sehloohong ho tsoelang pele ha lisele tsa atherosclerotic.
Ha o sebelisa li-nano drones tse nang le lintho tse phekoloang tse entsoeng ka protheine ea anti-inflammatory body ea A1, phetoho e kholo e ile ea finyelloa ka litoeba tse nang le atherosclerosis e tsoetseng pele. Hase feela hore ho ruruha ho fokotsehile, methapo ea litoeba e boetse e lokisoa, karolo ea phekolo e ikhethang ho mofuta ona o mocha oa phekolo.
Ho lokisa methapo ea mali e senyehileng e ka ba ea bohlokoa haholo bakeng sa ho thibela litlhaselo tsa pelo ebile e ka thibela palo ea ba shoang ka lebaka la atherosclerosis, eo hona joale e leng sesosa se ka sehloohong sa ho kula le lefu United States. Ho 'nile ha nahanoa hore mokhoa o mocha o lokela ho etsoa hantle le ho hlahlojoa ho batho, o fana ka tsela e thabisang ea ho phekola ho ruruha ka ho pepa ha libaka tsa peptide tse hlaselitsoeng, tse fumanehang sebakeng sa habo bona.
Bafuputsi ba Weldon School ea Biomedical Engineering, Univesithi ea Purdue, ba hlalosa mokhoa o mong oa katleho ea ho phekola ho ruruha ho sebelisa nanotechnology. Ba ile ba theha tsamaiso ea nanoparticle e kopantseng ea collagen e ka sebelisoang ho phekola lefu la methapo ea meriana. Mokhoa ona o mocha o sebelisa nanoparticles e tlameletsoe ho collagen le ho lokolla li-peptide tse khahlanong le ho ruruha. Li-nanoparticles li ka boela tsa fokotsa ho ruruha, hammoho le ho ts'ehetsa ho tsosolosoa ha lisele tse lemetseng.
Leqeba la Epithelial Re Lokisetsa le Nanoparticles
Ho lokisoa ha maqeba ke sebaka se seng sa phekolo moo nanoparticles e ka sebelisoang ka katleho ho tsamaisa mokhoa o boima oa pholiso. Giovanna Leoni le basebetsi-'moho le eena Univesithing ea Emory ba ile ba sebelisa mokhoa oa tsamaiso ea nanoparticles e nang le protheine e entsoeng ka tlhaho ea A1 ho intestinal mucosa e lemetseng.
Kotsi e sa foleng ea mucosal ke karolo ea maemo a mangata a ho ruruha a mala, ho kopanyelletsa le lefu la ulcerative le likokoana-hloko tsa Crohn tse amanang le Maamerika a limilione tse 1,6. Phuputso ea morao tjena ka litoeba e bontšitse hore tlhahiso e hlaselitsoeng ea lintho tse khahlanong le ho ruruha e ntlafatsa mokhoa oa ho folisa oa lisele tse tsoetseng likotsi 'me o khothalletsa ho lokisoa ha leqeba la sekhahla. Sehloohong sa bona, se hatisitsoeng ho Journal of Clinical Investigation , bangoli ba fana ka maikutlo a hore tlhahiso ea libaka tsa li-peptide tse kenngoa ka har'a nanoparticles e ka ba mokhoa o mocha oa phekolo bakeng sa batho ba nang le mafu a ho ruruha (IBD).
Ho bile le thahasello ho nts'etsopele ea nanoparticles e ka thusang ho tšoara maemo a kang IBD. Tlhaloso ea nanoparte e fumanoeng ka ginger e jeoang e sebelisitsoe ka katleho thutong e lebisoang ke MingZheng Zhang oa Georgia State University, Atlanta. Li-nanoparticles tsa tlhaho li ka 'na tsa fokotsa mathata a amanang le tlhahiso ea lik'hemik'hale tsa maiketsetso.
Nanomesh Ho apara Maqeba a Bohlokoa
Ntho e 'ngoe e ka sebelisoang ea nanotechnology e' nile ea bontšoa ke Martina Abrigo le sehlopha sa bafuputsi Univesithing ea Theknoloji ea Australia ea Swinburne. Abrigo o hlahloba lik'hamphani tse nyenyane tsa likaroloana tse nyenyane ho phekola maqeba a tšoaetsanoang ka nako e telele. O entse lesela le tsoang ho electrospun polystyrene fibers tse etselitsoeng ho hohela libaktheria ho tsoa leqeba. Nanomesh e fana ka maemo a ho hōla ka ho fetisisa bakeng sa libaktheria tse kang Staphylococcus Aureus le Escherichia Coli , ka hona li huleloa sefeng, ebe leqeba leo le hloekile. Karabo ea baktheria ho meshes ea fiber e fapaneng e fapaneng e ile ea lekoa ka ho kopanya ho hlahloba microscopy ea elektronike le microscopy ea confocal.
Libaktheria li ne li khahloa haholo ke likhoele tse neng li lekana le tsona. Litholoana, tse hatisitsoeng ho ACS Applied Materials le Interfaces , li fana ka maikutlo a hore li-nanofibers tse ka etsang motlakase li ka 'na tsa e-ba tsela e ncha ea ho laola maqeba a tšoaelitsoeng ke libaktheria tse tloaelehileng. Ho fihlela joale, bo-rasaense ba 'nile ba etsa liteko feela le liteko tsa lisele tse entsoeng ka letlalo. Leha ho le joalo, ho lebeletsoe hore haufinyane, liteko tse tšoanang li tla etsoa lithong tse phelang ho hlahloba bokhoni ba mokhoa ona o mocha. Lithuto tsa vivo li se li ntse li etsoa ka mefuta e meng ea liaparo tsa nanoparticle, ka mohlala, li-silver nanoparticles tse nang le katleho e itseng.
> Mehloli:
> Abrigo M, Kingshott P, McArthur S. Electrospun polystyrene fiber bophara e susumetsang baktheria, ho ata le ho hōla. ACS Applied Materials le Interfaces , 2015; 7 (14): 7644-7652.
> Fredman G, Spolitu S, Perretti M, le al. Linoparticles tse nkiloeng tse nang le peptide e phefumolohang Ac2-26 e sireletsa khahlanong le tsoelo-pele ea atherosclerosis ho litoeba tsa hypercholesterolemic. Setsebi se fetoletsoeng ke saense , 2015; 7 (275).
> Leoni G, Neumann P, Reutelingsperger C, et al. Sehlopha sa Annexin A1 'se nang le li-vesicles tse ling tsa extracellular le polymeric nanoparticles li khothalletsa ho lokisoa ha leqeba le seholo. Journal of Investigation ea Bongaka , 2015; 125 (3): 1215-1227.
> McMasters J, Panitch A. Nako e telele ea sehlooho: Collagen-ho tlama nanoparticles bakeng sa peptide ea anticelinlar anti-inflammatory ho fokotseha, ho khothalletsa ho fela ha ho falla, le ho thibela ho ruruha. Acta Biomaterialia , 2017; 49: 78-88.
> Zhang M, Viennois E, Merlin D, et al. Li-nanoparticles tse fumanoeng ka ginger-derived: Tsela e tloaelehileng ea phekolo ea ho thibela le ho phekola lefu la ho ruruha le lefu la kankere. Li-biomaterials , 2016; 101: 321-340.