Phello e Ntle ea Steroid e ka Etsoa ka Tšebeliso ea Nako e telele
Boloetse bo hlahang ha 'mele o pepeseha ho cortisol e ngata haholo. Cortisol ke hormone e hlahisoang ke 'mele' me e fumanoa hape lithethefatsi tsa corticosteroid. Cushing's syndrome e ka bakoa ke hobane cortisol e fetelloa ke 'mele kapa ho sebelisa lithethefatsi tse nang le cortisol (joaloka prednisone). Ha lefu la Cushing le bakoa ke tšebeliso ea nako e telele ea meriana ea corticosteroid, e boetse e bitsoa hypercortisolism.
Ho na le lisosa tse ling tsa Cushing's syndrome, tse kang hlahala. Cushing's syndrome ho nkoa e le ntho e sa tloaelehang.
Ka kakaretso, lingaka li tla sebetsa ho etsa hore bakuli ba tlohele lithethefatsi tsa steroid tse kang prednisone kapele kamoo ho ka khonehang. Ha ho phekoloa maloetse a ho ruruha (IBD), sepheo ke ho etsa hore bakuli ba fuoe ho fokotsa (ho fokotsa ho ruruha le matšoao) ntle le steroid kapa ka mokhoa o fokolang oa steroids. Lebaka ke hobane li-steroid, ha li ntse li atleha haholo, li ka ba le liphello tse tebileng le tse tšoarellang 'meleng, ho kenyeletsa nts'etsopele ea lefu la Cushing. Leha ho le joalo, tšebeliso e nepahetseng ea steroid e ka 'na ea e-ba e loketseng maemong a mang: ke khetho ea phekolo e lokelang ho tšohloa ka hloko. Haeba u e-na le lipotso mabapi le tšebeliso ea li-steroids le kotsi e ka 'nang ea e-ba teng ho latela melemo eo u nang le eona, buisana le gastroenterologist ea hau.
Ke Eng e Bakang Cushing's Syndrome?
Cortisol ke ntho e hlahisoang ke 'mele ka tlhaho, haholo-holo nakong ea linako tsa khatello.
Cortisol e na le mesebetsi e 'maloa, ho kenyelletsa le taolo ea ho ruruha le ho laola tsela eo' mele o sebelisang lik'habohaedreite, mafura le liprotheine. Corticosteroids e kang prednisone, e atisang ho sebelisoa ho phekola maemo a ho ruruha a kang Crohn's lefu le lefu la ulcerative, ho etsisa liphello tsa cortisol.
Lipontšo le Matšoao a Cushing's Syndrome ke afe?
Matšoao a Cushing's syndrome a ka kenyeletsa:
- ho tšoenyeha
- ho tepella maikutlong
- mefuta e phahameng ea tsoekere
- nyota e feteletseng
- mokhathala
- mafura a hump pakeng tsa mahetla
- ho khaotsa hangata
- khatello ea mali e phahameng
- bofokoli ba mesifa
- sefahleho se chitja
- Kenya matšoao ka mpeng, matsoho, matsoele, likoti le maotla (a boetse a bitsoa striae)
- boima ba 'mele' meleng o ka holimo
Ho ka 'na ha e-ba le matšoao a mang a boemo bona bo sa koaheloang ka holimo. Haeba u tšoenyehile ka hore u na le matšoao a mangata a Cushing's syndrome, bua le ngaka ea hau.
Cushing's Syndrome e Tšoaroa Joang?
Kamoo Cushing's syndrome e sebetsanoang ka ho fokotsa maemo a cortisol 'meleng. Tabeng ea boemo bo boima, tse kang lefuba la pituitary kapa lefu la adrenal gland, ho tla hlokahala phekolo e tobileng haholoanyane. Tabeng ea Cushing's syndrome e bakoang ke lithethefatsi, tekanyo ea corticosteroids e ka 'na ea hlokahala hore e fokotsehe' me e ka 'na ea khaotsa. Ho bohlokoa ho fokotsa butle-butle palo ea corticosteroid e nkiloeng libeke kapa likhoeli. Ho tlohela lithethefatsi ka tšohanyetso ho ka ba le liphello tse mpe 'meleng.
Haeba li-steroid li ke ke tsa emisoa, kapa haeba li nka nako e telele ho li thibela, lingaka tse ling li ka fanoa ho laola tse ling tsa matšoao a Cushing's syndrome.
Tse ling tsa likarolo tsa lefu lena tse ka 'nang tsa hloka phekolo ka meriana e meng le liphetoho ho lijo li akarelletsa tsoekere e phahameng ea mali le k'holeseterole e phahameng. Ho fokotsa kotsi ea ho robeha ha meriana ka meriana e sebelisoang ho phekola lefu la masapo ho ka 'na ha hlokahala hape. Tabeng ea ho tepella maikutlong kapa ho tšoenyeha, ho fetisetsoa ho setsebi sa bophelo bo botle ba kelello bakeng sa kalafo hape ho ka atleha.
Bakuli ba ka boela ba nka mehato e itseng lapeng ho phekola liphello tsa lefu la Cushing. Ho shebella lijo ka mekhoa e metle ho qoba ho fumana boima ba 'mele le litekanyetso tse phahameng tsa tsoekere ea mali, ho ikoetlisa kamehla, le ho theha mehato ea ho itšireletsa khatello ea kelello kaofela ho ka thusa.
The Bottom Line
Cushing's syndrome ke kotsing ea ho noa meriana ea steroid, empa ke ea seoelo. Cushing's syndrome e ka phekoloa ka ho fokotsa li-steroid tse nkiloeng, le ho phekola tse ling tsa matšoao. Sepheo sa kamehla ke ho fumana bakuli ba steroid ka potlako le ka mokhoa o sireletsehileng kamoo ho ka khonehang.
E boetse e tsejoa e le: hypercortisolism
Mohloli:
Mekhatlo ea Sechaba ea Bophelo. "Cushing's Syndrome." Setsi sa Sechaba sa lefu la tsoekere le mafu a likobo le a liphio (NIDDK). Mar 2012.
Sharma ST, Nieman LK. "Cushing's syndrome: mefuta eohle ea lintho, ho lemoha le kalafo." Endocrinol Metab Clinic North Am. 2011 Jun; 40: 379-391, viii-ix.