Lisele tse bolaeang tsa tlhaho li fumane tlhokomelo e ngata lilemong tsa morao tjena bakeng sa boikarabelo boo li bapalang ho itšireletsa bo ikhethang empa hape le karolo ea tsona ho loantša kankere. Haeba u ntse u mametse litaba tsa morao-rao litabeng tsa immunotherapy , ho akarelletsa le tsoelo-pele ea morao-rao kalafo ea kankere, u tla bona lisele tsena li hlaha hangata. Hantle-ntle lisele tse bolaeang ke tsa tlhaho, li sebetsa joang tsamaisong ea 'mele ea ho itšireletsa mafung, hona li thusa joang ho loantša kankere?
Tlhaloso ea Likokoana-hloko tsa tlhaho (NK)
Lisele tse bolaeang tsa tlhaho (NK cells) ke karolo e mabifi ea tsamaiso ea 'mele ea ho itšireletsa mafung e phethang karolo ea bohlokoa ho felisa lisele tsa kankere le lisele tsa tšoaetso ea kokoana-hloko ea' mele. NK cells ke mofuta oa lymphocyte , eo hape e leng o mong oa mefuta ea lisele tse tšoeu tsa mali 'meleng
Kamoo ba sebetsang kateng le ho itšireletsa mafung
E le karolo ea tsamaiso ea 'mele ea ho itšireletsa mafung, lisele tse bolaeang tsa tlhaho ha lia lokela ho lemoha mokhoa o sa tloaelehang (antigen) lisele tsa tšoaetso ea kokoana-hloko kapa lisele tsa kankere. Sena se fapane le mesebetsi e meng ea lisele tsa 'mele tsa immunente tse bakoang ke khopolo ea immunologic (mofuta oa mesebetsi eo liente li entsoeng ka eona). Haeba sele e sa tsejoe e le karolo e tloaelehileng ea 'mele, NK cell e ka etsa e' ngoe ea likarolo tse peli.
- NK lisele li ka 'na tsa e-ba cytotoxic (sele-bolaea): Ts'ebetsong ena, NK cell e kenella seleng ebe e ntša likhase tse chefo ka lisele tse sa tloaelehang. Li-granules tsena li ntan'o theha masoba ka seleng ea seleng, e ba lumella ho ruruha le ho phatloha le ho bolaea sele ka ho toba. Ho fapana le ho phatloha, sele e ka 'na ea tsamaisoa ka mokhoa o laolang lefu o bitsoang apoptosis.
- Lisele tse bolaeang tsa tlhaho li ka boela tsa sebelisoa e le mokhoa oa ho itšireletsa mafung: Metsing ea NK e laola mosebetsi oa sesole sa 'mele ka ho hlahisa lintho tse tsejoang e le cytokines . U ka bona eka li-cytokines ke "li-hormone tsa tsamaiso ea 'mele ea ho itšireletsa mafung" tse susumetsang likarolo tse ling tsa tsamaiso ea' mele ea ho itšireletsa mafung. Ke likarolo tse ling tsa tsamaiso ea 'mele ea ho itšireletsa mafung, eo hang ha e tsosolositsoeng, e fella ka lefu la sele ea kankere kapa sele e tšoaelitsoeng ke kokoana-hloko.
Patlisiso ea kankere
Kaha lisele tse bolaeang tsa tlhaho li khona ho bolaea lisele tsa tumor ka ho hlokomela phapang pakeng tsa lisele tsa kankere le lisele tse tloaelehileng bo-rasaense ba ithuta litsela tsa ho eketsa palo kapa ho ntlafatsa mosebetsi oa lisele tsena 'meleng, e le tsela ea ho phekola kankere ka katleho.
Na U ka Ntlafatsa Mosebetsi oa Mefuta ea Masole ea Tlhaho?
Phuputsong e 'ngoe e khothalletsang molemo oa boikoetliso, bafuputsi ba fumane hore ho ikoetlisa ka tsela e itekanetseng ho ka ntlafatsa mosebetsi oa lisele tse bolaeang tsa tlhaho ho batho ba nang le kankere. Ka lehlakoreng le leng la equation, ho tsuba ho bonahala eka ho sitisa lisebelisoa tsa bolaoli ba tlhaho, le ho khaotsa ho tsuba ke tsela e le 'ngoe ea ho netefatsa hore lisele tsa' mele tsa 'mele oa hao li sebetsa ka hohle kamoo ho ka khonehang.
Ntho e ka tlaase
Lisele tse bolaeang tsa tlhaho ke karolo ea bohlokoa ea sesole sa hau sa 'mele, haholo-holo ka mesebetsi eo ba e bapalang ho felisa lisele tsa tšoaetso ea kokoana-hloko le lisele tsa kankere. Lipatlisiso li ntse li tsoela pele ho sheba litsela tsa bobeli tse matlafatsang mosebetsi oa lisele tsena le ho eketsa palo ea tsona e le mokhoa oa ho loantša kankere.
Taba ea hore ho na le lintho tseo u ka iketsetsang tsona tse ka amang lisele tsa hau tsa tlhaho. Ho ikoetlisa ho bonahala ho eketsa palo ea bona le ho tsuba ho ba fokotsa.
Ha re ntse re ithuta ka ho itšireletsa mafung a kankere re sa ithute mekhoa e mecha feela ea ho loantša lihlahala empa ke litsela tseo ka tsona re ka ts'ehelang tsamaiso ea rona ea 'mele ea ho itšireletsa mafung ho loantša tsena kankere.
E boetse e tsejoa e le : NK cells, Large Granular Lymphocyte, NK-LGL
> Mehloli:
> Carotta, S. Targeting NK Lisele tsa Anticancer Immunotherapy: Mekhoa ea kalafo ea meriana le ea mekhoa e metle. Meeli ea Immunotherapy . 2016. 21: 7-152.
> Mehta, H. et al. Ho tsuba koae le ho itšireletsa mafung. Lipatlisiso tsa ho ruruha . 2008. 57 (11): 497-503.
> Purdy, A. le K. Campbell. Lisele tse bolaeang tsa tlhaho le kankere: taolo ea bolaoli ba cell Ig-like receptors (KIR). Cancer Biology & Therapy . 2009. 8 (23): 2211-20.
> Srivastava, S. le al. Tlhaselo ea tlhaho ea immunotherapy bakeng sa kankere: tšepo e ncha. Cytotherapy . 2008. 10 (8): 775-83.
> Tallerico, R., Garofalo, C., le E. Carbone. Tšebetso e Ncha ea Likokoana-hloko ea Makala a Bolaoang ke Tlhaho: Ho Amoheloa ha Moriana o Matla oa Kankere. Meeli ea Immunology . 2016. 10: 7-179.