Mangolo a Molecular
Li-cytokines li sebeletsa e le manģosa a limolek'hule pakeng tsa lisele. Li-cytokine ke liprotheine tse hlahisoang ke lisele. Mabapi le ramatiki, li-cytokine li laola likarabo tse sa tšoaneng tsa ho ruruha . Li-cytokines li sebelisana le lisele tsa sesole sa 'mele ea ho itšireletsa mafung e le hore li laole tsela eo' mele o arabelang ka eona ho mafu le tšoaetso, hammoho le ho sebetsana le mekhoa e tloaelehileng ea lik'hamera 'meleng.
Mefuta ea li-Cytokines
Li-cytokines li fapane, ho bolelang hore ha li tšoane ka ho lekana. Li-Cytokines li sebeletsa mesebetsi e sa tšoaneng 'meleng:
- lintho tse susumetsang li-colony (ho susumetsa tlhahiso ea lisele tsa mali)
- ho hōla le maemo a khethollang (ho sebetsa haholo-holo ho nts'etsopele, tlhokomelo ea lisele le ho lokisa)
- li-immunoregulatory le proinflammatory cytokines (mohlala, interferons, interleukins, le TNF-alpha e sebetsang tsamaisong ea 'mele ea ho itšireletsa mafung)
Le hoja "li-cytokine" e le sekhele se akarelletsang mefuta eohle, ho na le mabitso a khethehileng a fanoeng ho li-cytokines tse thehiloeng ho mofuta oa sele e etsang hore ba be le ketso eo ba nang le eona 'meleng:
- lymphokines (e entsoeng ke lymphocytes)
- li-monokine (tse entsoeng ke monocyte)
- li-chemokine (tse amanang le liketso tsa lik'hemik'hale)
- li-interleukins (tse entsoeng ke leukocyte e le 'ngoe empa li etsa likochote tse ling)
Kamoo Cytokines e Sebetsang Kateng
Tsamaiso ea 'mele ea ho itšireletsa mafung e rarahane - mefuta e fapaneng ea lisele tsa' mele le liprotheine li etsa mesebetsi e fapaneng. Li-cytokine li har'a liprotheine tseo.
Ho hlalosetsa hore na li-cytokines li sebetsa joang. Ke thuto ho cell physiology. Empa, ho utloisisa ho ruruha, o tlameha ho utloisisa karolo eo li-cytokine li e bapalang.
Li-cytokine li lokolloa ke lisele tse kenang ho tse ling kapa tse hlahelang ka ho toba. Li-cytokines li fumana lisele tsa 'mele tsa ho itšireletsa mafung' me li kopana le li-receptors setsing se hlaselang sa 'mele ka ho li tlama.
Likamano li baka kapa li susumetsa likarabo tse tobileng ke lisele tse hlalositsoeng.
Ho ruruha ha li-Cytokines
Ho ruruha haholo kapa tlhahiso e sa lokelang ea li-cytokine ka 'mele ho ka fella ka maloetse. Ka mohlala, ho fumanoe hore interleukin-1 (IL-1) le tumor necrosis factor-alpha (TNF-alpha) li hlahisoa ka ho feteletseng tabeng ea ramatiki ea lefuba moo li amehang ho ruruha le ho bolaoa ha methapo.
Lithethefatsi tsa Biolotiki li na le likokoana-hloko tse thibelang likokoana-hloko
Li-biologic lithethefatsi li entsoe ho thibela IL-1 kapa TNF-alpha. Kineret (anakinra) e ile ea hlahisoa e le phekolo ea ramatiki ea lefu la rheumatoid 'me e sebetsa ka ho thibela ho tlamisoa ha IL-1 ho mokelikeli oa eona. TNF-alpha inhibitors (e boetse e bitsoa TNF blockers ) e tlama TNF mme e thibela TNF hore e se ke ea khomarela li-cell receptors. Enbrel (etanercept), Remicade (infliximab), Humira (adalimumab), Simponi (golimumab), le Cimzia (certolizumab pegol) ke TNF blockers. Actemra (tocilizumab) e tlama IL-6.
Lithethefatsi tse ngata tsa biologic li nts'etsopele. Thuto e fumanoang ho tsoa thuputsong ea bohlokoa ea Phase 3 ea sarilumab (e bitsoang SARIL-RA-TARGET), motho ea loantšang motho khahlanong le mokete oa IL-6, o senole hore moriana o kopane ka bobeli bofelo ba 'mele oa ho ntlafatsa matšoao a lefu la ramatiki le ntlafatso ea' mele sebetsa.
Sarilumab e tlamahanngoa haholo le ho amohela IL-6, e thibela ho tiisoa ha IL-6 le ho senya pontšo ea ho ruruha ha cytokine. Leha ho le joalo, ka la 31 October, 2016, FDA e ile ea hana sarilumab e itšetlehile ka bofokoli boo ba bo fumaneng nakong ea tlhahlobo ea mokhoa oa ho etsa. Hang ha ho etsoa litokisetso, Regeneron le Sanofi ba ikemiselitse ho boela ba li romella ka tumello ka 2017. Khabareng, ka la 1 February, 2017, Health Canada e lumeletse lithethefatsi tlas'a lebitso, Kevzara (sarilumab).
Lentsoe le Tsoang ho
Le hoja li-cytokine li bonahala e le taba e rarahaneng, ke habohlokoa ho utloisisa mokhoa oa ho ruruha o leng mokokotlong oa mefuta e mengata ea ramatiki.
Rea tseba hore ho na le liproinflammatory cytokines le li-anti-inflammatory cytokines. Li-protofinmatory cytokines li phetha karolo ea ho ntšetsa pele bohloko bo bakoang ke ho ruruha le lefu la pelo. Li-cytokines tse khahlanong le ho ruruha ha e le hantle li hanyetsa bahanyetsi ba cytokine. Ho na le bopaki bo bontšang hore lik'hemikine li ameha ho qobeng bohloko, hammoho le ho phehella ha bohloko.
> Mehloli:
> Lintho tsa ho hōla le li-Cytokines. > Primer > ho Rheumatic Diseases. Khatiso 12. E hatisitsoeng ke Arthritis Foundation.
> Regeneron le Sanofi Phello e hlahang ho Thuto ea Bohlokoa ea 3 ea Sarilumab Kopanong ea selemo le selemo ea American College of Rheumatology. Regeneron. La 8 November, 2015.
> McInnes I. le Schett G. Cytokines ka pathogenesis ea ramatiki ea ramatiki. Tlhaho ea Immunology. June 2007
> Li-cytokines. BioBasics. 4/24/2006.
> Zhang, JM le al. Li-Cytokines, Inflammation > le > Bohloko. Lipetlele tsa Machaba tsa Anesthesiology. Selemo sa 2007.