Immunohistochemistry (IHC) ke teko e ikhethang e sebelisoang ke li-pathologist ho fumana limolek'hule tse khethehileng ka lisele.
Ha lisebelisoa tsa mahlaseli a kang lymph node biopsy li fetisetsoa ho laborateng tse lokelang ho hlahlojoa bakeng sa maloetse, ho na le lintlha tse ngata tse sa tsejoeng habonolo.
Mefuta e 'maloa ea maloetse kapa maloetse a ka shebahala ka tsela e ts'oanang kapa e bonahala e e-na le lisele tsa boholo bo tšoanang tlas'a microscope empa li na le mekhoa e sa tšoaneng le mekhoa e fapaneng ea phekolo.
Tsela e 'ngoe ea ho li khetholla ke ho bona limolek'hule tse khethehileng lisele tsena tse sebetsang joaloka li-marker.
Immunohistochemistry ke mokhoa o sebelisang li- molecule-limolek'hule-tse ka batlisang, ho khetholla le ho ikamahanya le tsona ho tse ling tsa lisele. Li-antibodies li etselitsoe hore li sebetse ka mekhabiso e ka fumanoang kapa e bonoang tlas'a microscope, e kang ho silafatsa ho foorescent, e leng ho thusang ho etsa khetho e tobileng.
IHC e fumane mekhoa e mengata ea meriana, haholo-holo kankere ea ho hlahlojoa ke kankere. Lymphomas ke tse ling tsa lik'hemik'hale tse itšetlehileng haholo ka IHC bakeng sa liqeto tse nepahetseng tsa ho hlahlojoa le ho phekoloa.
Ho feta ho Immunohistochemistry
Likarolo tse ling tsa lefu li ka bonoa habonolo ka ho ithuta lisele tse le 'ngoe le ponahalo ea tsona, ho kenyeletsa le ponahalo ea mokokotlo, liprotheine tse itseng tsa cellular, le sebopeho kapa "tloaelehileng ea tlhaho" ea sele, e bitsoang cell's morphology. Likarolo tse ling tsa lefu li bonahala ho motho ea shebileng hafeela lisele tse belaetsang li bonoa ho latela "sebaka sohle" sa lisele.
Lintlha tse ling li hloka tlhahlobo ea limolek'hule-ka mantsoe a mang, lingaka li hloka ho tseba ka lihlahisoa tse khethehileng tsa liphatsa tsa lefutso-polelo ea liphatsa tse ling tsa liphatsa tsa lefutso ka liprotheine, kapa lisebelisoa tse ka fumanoang ka li-antibodies.
Ka linako tse ling immunohistochemistry ha e thuse feela ho khetholla mofuta o itseng oa lymphoma empa hape ho thusa ho theha mokhoa oa ho hlasela, ho thehiloe likarolong tse amanang le boitšoaro bo ntseng bo hōla butle-butle khahlanong le mofuta o mong o mabifi.
IHC bakeng sa Lymphomas
Li-lymphomas li nkoa e le lihlong tsa lymphocyte tse emisitseng ka mekhahlelo e fapaneng ea nts'etsopele kapa phapang, 'me tšebeliso ea IHC le li-antibodies tse fapaneng "karolong" e thusa ho khetholla moeli o tobileng le ntshetsopele ea lymphoma.
Sehlopha sa li-antibodies tse sa tšoaneng se sebelisetsoa ho bona hore na ke lintlha life tse teng li-lymphocytes. Hangata matšoao a qala ka mangolo a CD. Ka mohlala, li-B-cell markers (CD20 le CD79a), lik'hamera tsa T-cell (CD3 le CD5), le likarolo tse ling tse kang CD23, bcl-2, CD10, cyclinD1, CD15, CD30, ALK-1, CD138 li ka sebelisoa mafu a mang a kankere ea mali kapa likokoana-hloko tsa mali.
Nahana ka follicular lymphoma (FL) ka botebo bo tebileng e le mohlala oa lintho tse ling tse ka etsoang ka IHC. FL ke karolo ea bobeli e tloaelehileng ka ho fetisisa eo e seng ea Hodgkin's lymphoma-e leng e kholo ea B-cell lymphoma (DLBCL) e tloaelehileng ka ho fetisisa. FL e boetse e le mohlala oa se tsejoang e le indolent lymphoma, e bolelang hore ke kankere e khetholloang ke ho hōla butle le nako e telele ea ho phela, esita le ntle le phekolo. Ho na le mefuta e mengata ea phekolo e fapaneng ea FL, empa lefu lena ka litsela tse ling le ka fapana le motho ka mong.
Ho na le li-indices tsa boeletsi, tse kang International Index of Prognostic Index, haholo-holo, Follicular Lymphoma International Prognostic Index (FLIPI) e ka thusang ho fana ka setšoantšo sa mofuta oa FL oo u sebetsanang le oona, le hore na o ka itšoara joang.
Ka nako e 'ngoe, ho hlahlojoa ha IHC ea lymphoma le "microenvironment" ea eona ho ile ha ithutoa ho bona hore na liphuputso li tla tsamaisana le boitšoaro bo fapaneng ba lingaka, ho ea ka phuputso ea 2006 e hatisitsoeng "Journal of Clinical Oncology."
Lisebelisoa:
Yohe S. Mekhoa ea Likokoana-hloko ea Likokoana-hloko Mokhoeng oa Myeloid Leukemia. Ustun C, Godley LA, eds. Journal of Clinical Medicine. 2015; 4 (3): 460-478.
Lee HJ, Thompson J, Wang ES, le al. Philadelphia chromosome-positive acute lymphoblastic leukemia: Kalafo ea morao-rao le bokamoso ba nako e tlang. Kankere . 2011; 117 (8) 1583-1594.
Somoza AD, Aly FZ. Sehlopha sa liteko tsa molek'hule ka cytopathology. CytoJournal . 2014; 11: 5
Alvaro T, Lejeune M, Salvadó MT, et al. Li-immunohistochemical patterns tsa microenvironment tse tsitsitseng likokoana-hloko li amahanngoa le boitšoaro ba litsebi tsa bophelo bo botle ba bakuli ba follicular lymphoma. J Clin Oncol. 2006; 24 (34): 5350-7.
Rao IS. Karolo ea immunohistochemistry ka lymphoma. Indian j med paediatr oncol. 2010; 31 (4): 145-147. doi: 10.4103 / 0971-5851.76201.