Ts'ebetso ea Ts'oaetso ea Nervous System e atisa ho koaloa ke Parkinson
Mefuta e mengata ea methapo ea methapo (MSA) ke boloetse bo bakang likarolo tse ngata tsa tsamaiso ea methapo hore e fokotsehe. MSA e kenyelletsa syndromes tse tharo: lefu la Shy-Drager, degeneration ea striatonigral, le olivopontocerebellar atrophy. MSA ke lefu le tsoelang pele le amang tsamaiso ea methapo ea boithati, karolo ea 'mele oa hao e laolang liketso tse sa tsebeng ho ts'oaroa le ho phefumoloha.
MSA e ama kae kapa kae ho batho ba babeli ho isa ho ba 15 ka 100,000. Ho ka nka nako ho fumana lefu la MSA ka lebaka la ho tšoana pakeng tsa MSA le maemo a mang, a kang lefu la Parkinson . MSA hangata e fumanoa e le lilemo tse 50 'me e bonoa ho batho ba merabe eohle. Hang ha matšoao a qala, lefu lena le atisa ho hatela pele ka potlako.
Matšoao a Mefuta e mengata ea Atrophy
MSA matšoao a bakoa ke ho lahleheloa ha lisele tsa methapo mokhoeng oa methapo. Se etsang hore tahlehelo ena ea lisele tsa methapo e sa tsejoe. Batho ba bangata ba nang le MSA ea pele ea bolotsana ea syndrome, e leng ho se sebetse ha meriana, ho fokotsa khatello ea mali ha ba eme (orthostatic hypotension), ho senyeha le ho patoa. Ha matšoao a ntse a tsoela pele, a oela tlas'a lihlopha tse peli:
- Mofuta oa Parkinsonian (MSA-P): sena se akarelletsa matšoao a tšoanang le a Parkinson a kang ho thothomela ha ho phomola, ho tsitsisa ha mesifa le ho qeta nako e khutšoanyane
- Mofuta oa Cerebellar (MSA-C): o kenyeletsa ho thatafalloa ho tsamaea (ataxia), ho rarolla ho boloka botsitso, le mathata ho hokahanya mehato ea boithatelo.
Matšoao a mang a amanang le MSA a kenyeletsa bothata ba ho bua kapa ho koenya, ho robala le ho robala, le matsoho a batang. Batho ba bang ba ka 'na ba ba le bothata ba ho robala, mesifa le methapo ea ho khutsufatsa, lefu la Pisa - moo' mele o bonahalang o itšetlehile ka lehlakoreng le le leng, ho feheloa ka boithati le antecollis - e etsahalang ha molala o khumamela 'me hlooho e theohela fatše.
MSA e fumanoa joang
Ho ka ba thata haholo ho khetholla MSA ho tswa ho lefu la Parkinson . Tsela e 'ngoe ea ho khetholla lipakeng tsena ke ho sheba kamoo lefu lena le potlakileng kateng. MSA e atisa ho hatela pele ka potlako ho feta Parkinson's. Batho ba bangata ba nang le MSA ba tla hloka lisebelisoa tse thusang, joaloka setulo sa ba holofetseng kapa molamu, ka mor'a lilemo tse 'maloa ba fumanoa.
Tsela e 'ngoe ea ho khetholla lipakeng tsena ke ho tšoara Parkinson. MSA ha e arabele hantle le levodopa, meriana e sebelisetsoang ho tšoara Parkinson. Ka bomalimabe, autopsy ke eona feela tsela ea ho hlahloba ka botlalo MSA. Liteko tse khethehileng, tse kang PET scan (positron emission tomography), li ka hlahisa mefuta e meng ea mathata a sa tloaelehang a methapo ea pelo.
MSA Treatment
Hajoale, ha ho na pheko ea MSA, ebile ha ho na phekolo e ikemiselitseng ho fokotsa kapa ho thibela ho tsoela pele ho kula. Likarolo tse ling tsa lefu lena li fokolisa ebile ho thata ho li phekola. Mathata a mokoloko a ka phekoloa ka levodopa le carbidopa (Sinemet), empa hangata sena se na le liphetho tse fokolang.
Meriana e meng e kang bromocriptine (Parlodel), trihexyphenidyl (Artane), benztropine mesylate (Cogentin), le amantadine (Symmetrel), e ka boela ea fana ka phomolo e itseng ea matšoao.
Phekolo ea meriana, ho kopanyelletsa le phekolo ea aqua, e ka thusa ho boloka mesifa e sebetsa, le phekolo ea puo e ka thusa ho ntlafatsa mathata leha e le afe a ho emisa kapa a buang.
Seo Patlisiso e se Buang
Ha ho tsejoe hanyane mabapi le mekhoa ea mosebetsi mosebetsing oa multiple system. Bafuputsi ba National Institute of Neurological Disorders le Stroke (NINDS) ba ntse ba leka ho utloisisa hore na ke hobane'ng ha protheine alpha-synuclein e eketsa liseleng tsa glial (lisele tse fanang ka tšireletso bakeng sa methapo ea tsamaiso ea methapo) ea batho ba nang le MSA le neuronal (methapo) ea batho ba nang le lefu la Parkinson. Tlhahlobo ea meriana ea meriana e ile ea leka ho sebelisa rifampicin ea lithethefatsi ho fokotsa ho kula ha mafu, empa phekolo e ne e sa sebetse.
Lintlha tsa thuto ena li se li sebelisoa lithuto tse ling tsa MSA.
Lisebelisoa
Diedrich, A., & Robertson, D. (2002). Tsamaiso e mengata ea tsamaiso ea tsamaiso. eMedicine, fihlella ho http://www.emedicine.com/neuro/topic671.htm
Setsi sa Sechaba sa Matšoenyeho a Neurological le Stroke. Lintlha tse ngata tsa Atrophy Fact Sheet. November 2014.