Histamine ke lik'hemik'hale tse fumanoang le ho lokolloa ke lisele tse ngata tse ka lebisang matšoao a itseng ho itšetlehile ka karolo ea 'mele moo ho lokolloa ha histamine ho teng:
- Nose: nko ea mathe
- Mahlo: ho monate, metsi
- Ntho e bohloko: e bohloko, e makatsang
- Makala: ho ruruha , sefuba sefubelu , phefumoloho e khutšoanyane , le ho khohlela
Histamine e sebetsa joang
Histamine ke mokena-lipakeng oa sesole sa 'mele kapa, ka mokhoa o bonolo feela, e leng setsi sa lik'hemik'hale se thusang ho lebisa karabelo ea' mele oa hao ho bahlaseli ba tsoang linaheng tse ling.
Histamine e bolella mekhoa ea tlhaho ea tlhaho ea ho itšireletsa hore na u ka itšoara joang ho seo e nkang e le molichaba. Ha u ntse u tšoeroe ke lefu la pherekano le mafu a mangata, 'mele oa hao o fetela ho hong ho seng kotsi haholo empa o entse hore tsamaiso ea hau ea' mele ea ho itšireletsa mafung e sebetse. Histori e sebetsa joaloka koloi ea lipuisano pakeng tsa likarolo tse fapaneng tsa tsamaiso ea 'mele ea ho itšireletsa mafung.
Ka asthma, histamine e khothalletsa batho hore ba se ke ba hlola ba e-ba le lik'hemik'hale.
Histori e Tsoaloa Hokae?
Histori e lokolloa ho tloha ho li-cell mast le basophils ha u pepesehetse lisele tse ling. Ha histamine e lokolloa, karabo ea allergic e qala. Lithethefatsi tsa antihistamine li sebelisetsoa ho phekola matšoao a hlaselang a bakoang ke ho lokolloa ha histamine. Meriana e meng e tummeng ea anti-histamine e kenyeletsa:
- Zyrtec
- Allegra
- Claritin
- Benadryl
Lithethefatsi Tse Fetohang Leukotriene
Sehlopha se seng sa lithethefatsi tse buang ka liphello tsa histamine ke liphetoho tsa leukotriene.
Lithethefatsi tsena li fokotsa li-bronchoconstriction le ho fokotsa lihlahisoa tsa li-mucus le ho fokotsa li-edema kapa ho ruruha hammoho le tlhahiso ea li-eosinophil e le karolo ea pathophysiology ea asthma.
Lithethefatsi tsena li batla li mamelletsoe ke bakuli 'me liphuputso tse ngata li tlaleha ho khomarela habonolo phekolo ena ha ho bapisoa le phekolo e' ngoe ea lefuba.
Bongata ba mangolo a bona a lithethefatsi a khothaletsa ho hlahlojoa ka nako e itseng ea matšoafo, e lokelang ho ba karolo ea moralo oa hau oa tlhokomelo ea asthma. Ho phaella moo, ho 'nile ha e-ba le likamano tse tsejoang le mali a fokolang a warfarin hammoho le liphetoho tsa boitšoaro tse boletsoeng lilemong tsa bocha. Le hoja ho tepella maikutlong ho ne ho tloaelehile haholo ho bacha ba phekoloang, ho ne ho se na keketseho ea ba ipolaeang ba boletsoeng.
Liphuputso tse ngata li bontšitse phello ea bronchodilatory hammoho le ntlafatso ea matšoao a asthma. Mehato e meng ea bohlokoa ea liphello e ne e bolela tšebeliso e fokolang ea menyetla ea pholoso , hammoho le ho fokotseha ha maemo a matšoafo le liketsahalo tse hlokang li-steroids tsa molomo joaloka prednisone . Leha ho le joalo, lithethefatsi tsena ha li bonahale li le matla joaloka li-steroids tse khotsofatsang bakeng sa asthma ea hau. Liphuputso tse 'maloa tse fapaneng li bontšitse hore ntlafatso ea ts'ebetso ea matšoafo e phahametse li-steroid tse halefisitsoeng, ho fokotseha ho fokotseha ho fokolang,' me bakuli ba na le matsatsi a mangata a se nang matšoao. Ka lebaka leo, tataiso ea sechaba e fana ka khothaletso e hlakileng ea hore li-steroids tse kenyelletsoeng ke li-steroid e le kalafo ea pele ha u hloka ho feta ho pholosa inhaler.
Hoa tsebahala hore ho mamella ha mamello ho steroid e halefisitsoeng ke ntho e lekaneng, 'me lipatlisiso tse ngata li bontšitse ho boloka mokuli ho feta letsatsi le leng le le leng ha ho bapisoa le li-steroid tse khotsofatsang ho bana le ho batho ba baholo.
Hangata batsoali ba tšoenyeha ka litla-morao tsa steroid tse haelitsoeng 'me hangata ba tlas'a litaelo tsa lingaka.
Ho khomarela holimo ho montelukast ho ka hlalosetsa liphello tsa eona tse ntle tse amanang le taolo ea asthma ho tse ling tsa GC e kenyelletsoeng liphuputsong tse ling tsa "lefatše la sebele". Ho sa tsotellehe bohlokoa ba taba ena mererong ea bongaka, haholo-holo e thibetsoe litsing tsa meriana, lipatlisiso tse lebisang tlhokomelong ea lithethefatsi ke FDA, ka ho ba le lihokahanyo tsa thuto ho fana ka likhopotso hangata ho bakuli le ka ho se kenyele bakuli ba bona bao ho bonahalang ho bona (joalokaha ho ngotsoe ke lihlohlohlo tsa elektronike e hahiloeng ka lisebelisoa tsa inhaler) e futsanehile.
Hape hoa hlaka hore lingaka tsa tlhokomelo ea mantlha li atisa ho beha li-steroid tse khotsofatsang. Ka hona, ho sa tsotellehe hore na li-steroids tse sebetsang hantle li ka sebelisoa hakae, li sebelisoa ha li ntse li e-na le maemo a sebele li lekanyelitsoe ka ho lekaneng ho hlalosa le ho khomarela.
Le hoja e se khetho e khethiloeng e itšetlehile ka tataiso ea hona joale ea asthma, liphetoho tsa leukotriene ke mokhoa o utloahalang joaloka moemeli oa mohala oa pele oa meriana bakeng sa bakuli ba ke keng ba nka kapa ba sitoang ho mamella steroids e haelitsoeng. Ho netefatsoa ha mokhoa ona ho tšehetsoa ke teko e bitsoang "pragmatic" e ileng ea etsoa ho bakuli ba 306 ba hlokometsoeng mekhoeng ea tlhokomelo ea mantlha, moo montelukast e ileng ea bontšoa e ka bapisoa le li-steroids tse sa tšoaetsanoang e le phekolo ea molao ea pele.
> Mohloli
> Busse le al. Moriana o monyenyane oa fluticasone propionate o bapisoa le montelukast bakeng sa phekolo ea pele ea asthma e tsitsitseng: Tlhahlobo ea lits'ebeletso tsa meriana. J Allergy Clin Immunol 2001; 107: 461-8
> National Heart, Lung le Blood Institute. Tlaleho ea Panel ea litsebi 3 (EPR3): Litaelo tsa Tlhahlobo le Tsamaiso ea Pherefatsi
> Scaparotta A et al. Montelukast khahlanong le ho ruruha ha corticosteroids ho laoloang ke mafu a fokolang ea asthma. Multidiscip Respir Med. 2012; 7 (1): 13.