Likokoana-hloko tse 'maloa - ho akarelletsa libaktheria, likokoana-hloko (tse kang kokoana-hloko ea Epstein-Barr) le likokoana-hloko -li amahanngoa le lymphoma. Ha e le hantle, hoo e ka bang karolo ea 18 lekholong ea likarabo tsa kankere lefatšeng lohle e ka amahanngoa le likokoana-hloko, ho hakanngoa hore ho na le tekanyo e ' Leha ho le joalo, ho pepesehela likokoana-hloko feela ha hoa lekana ho etsa hore malignancy e be maemong a mangata. Ho na le mabaka a mang a bohlokoa a motho ka mong a bapalang, ho kenyeletsa liphatsa tsa lefutso le phapang ea motho ka mong ho itšireletsong ea 'mele ea' mele ka lebaka la mafu ana.
EBV le Lymphoma
Lefu la Epstein-Barr (EBV), kokoana-hloko e bakang mafu a tšoaetsanoang mononucleosis , e ama batho ba bangata lefatšeng ka bophara. Ha e le hantle, karolo ea 90 lekholong ea batho bohle ba qetella ba tšoaelitsoe ke EBV, 'me kokoana-hloko e tsoelapele bophelo bohle, le hoja boteng ba eona e ka ba bo sa reng letho ho ba bangata. Matšoao a mangata a EBV ho bana a na le tšoaetso kapa a baka matšoao a sa tsejoeng, athe tšoaetso e teng pele nakong ea bocha e ka fella ka ho tšoaetsoa ke mononucleosis ka karolo ea 50 lekholong ea bakuli.
Se etsang hore EBV e fapane ho ea ho maikutlo a lymphoma ke hore e na le liphatsa tsa lefutso tse ikhethang tse etsang hore ho hōle ha lisele ho e fetise. EBV e ama haholo-holo lisele tsa mofuta oa B (mofuta oa sele e tšoeu ea mali). Le hoja boholo ba nako tšoaetso e baka tšenyo e nyenyane, ka linako tse ling liphatsa tsa lefutso tsa ho hōla li-B-lisele li ka amahanngoa le kankere ho batho ba itseng. Ka hona, EBV e nkoa e le kotsi ea mofuta oa lymphoma.
Post-Transplant Lymphoma le AIDS-Associated Lymphoma
EBV e amahanngoa haholo le ho hlahisa lymphoma ka mor'a hore litho li fetoloe . Kamora 'mefuta efe kapa ofe ea phetoho ea setho , ba fumanang phetoho ba lokela ho fuoa lithethefatsi tse thibelang karabo ea' mele ea ho itšireletsa mafung. Sena se nolofalletsa setho sa motsoako ho thibela ho itšireletsa mafung ka mofani, empa lithethefatsi tsena, ka bomalimabe, li ka fokolisa tsamaiso ea 'mele ea ho itšireletsa mafung' me ea etsa hore 'mele o khone ho fumana tšoaetso e fapaneng ea kokoana-hloko, ho akarelletsa le EBV.
Nakong ea AIDS hape, ho na le tahlehelo ea tšireletso ea 'mele ea ho itšireletsa mafung ka lebaka la tšoaetso ea kokoana-hloko ea' mele meleng. Maemong a mang, likokoana-hloko tse kang EBV li ka baka kholo e sa tloaelehang ea lisele tse nang le tšoaetso ea B le ho thusa ho li fetola lymphomas.
Burkitt's Lymphoma le Malaria
Burkitt lymphoma, kapa BL, ke eona e tloaelehileng ka ho fetisisa eo e seng Hodgkin lymphoma ho bana le bacha ho pota lefatše. Libakeng tse ngata tsa Afrika, EBV e amana haholo le Burkitt's lymphoma . Ka ho khetheha, ho ba le tšoaetso ea pele ea EBV ho amana le nts'etsopele ea BL. EBV e baka liphetoho tse khethehileng tsa liphatsa tsa lefutso tse thusang hore li-B-cell li be le kankere. Ho pheta tšoaetso ea malaria ho boetse ho thusa EBV ho baka lymphomas.
Lefu lena le ile la bitsoa Dr. Denis Burkitt, moromuoa oa Ireland, le ngaka e buoang e neng e sebetsa Afrika. Burkitt le basebetsi-'moho le eena ba ile ba fumana BL ka 1957, moo ho neng ho e-na le linyeoe tse ngata libakeng tseo malaria a neng a le teng-se bitsoang lebanta la lymphoma. Leha ho le joalo, malaria ke likokoana-hloko tse fokolang lisele tse khubelu tsa mali, eseng lisele tse tšoeu tsa mali tsa lymphoma, kahoo mokhoa o tobileng o ne o bile sephiri ka lilemo tse 50.
Leha ho le joalo, lehlabuleng la 2015, ho ile ha tšolloa leseli le itseng tabeng ena, le hoja lithuto tsa liphoofolo li ntse li le teng. Ho sebetsa le litoeba, bafuputsi Univesithing ea Rockefeller e etelletsoeng ke Michel Nussenzweig ba fumane hore enzyme e tšoanang e thusang ho etsa hore li-antibodies e loantše malaria e baka le tšenyo ea DNA e ka lebisang Burkitt's lymphoma.
Phuputso e ile ea hatisoa ka August 2015 makasineng ea "Cell."
Lymphoma ea Hodgkin
Hodgkin's lymphoma , kapa HL, ke mofuta o mong oa lymphoma o amanang le EBV. Linaheng tsa bophirimela, hoo e ka bang karolo ea 40 lekholong ea batho ba nang le HL le bona ba tšoaelitsoe ke EBV. Lebelo la tšoaetso le ka ba le phahameng likarolong tse ling tse ngata tsa lefats'e. Mokhoa o tobileng oo EBV e ka 'nang ea baka Hodgkin's lymphoma ha o utloisisoe hantle, empa hoa bonahala hore EBV e na le karolo ea bohlokoa e lokelang ho etsoa ho nts'etsopele ea lymphoma ena. Le hoja e ka amahanngoa le mefuta e sa tšoaneng ea lefu la Hodgkin, e tloaelehileng ka ho fetisisa ke mefuta e mengata e tsoakaneng, Hodgkin's lymphoma ea khale.
HL ho lihlopha tsa khale le ho bana, haholo-holo bashanyana ba ka tlase ho lilemo tse 10, ho bontšitsoe hore ho ka etsahala hore e be EBV-e amanang le HL ho batho ba baholo.
EBV-positive e fokolang B-cell Lymphoma ea ba hōlileng
Le hoja boholo ba B-cell lymphoma (DLBCL) bo tsebahala ka nako e teletsana, DLBCL ea batho ba hōlileng e e-na le EBV e ile ea hlalosoa ka lekhetlo la pele ka 2003, 'me e thathamisitsoe ka nakoana tsamaisong ea lihlopha tsa World Health Organization ea 2008 - e bolelang "EBV e leng monokolone e khōlō ea B-cell e hlahisoang ke bakuli> lilemo tse 50 'me ho se na tsebo ea immunodeficiency kapa histori ea lymphoma. "Lefu lena le atile haholo Asia empa hape le hlaha Amerika Leboea le Europe ka maqhubu a tlase .
> Mehloli:
> Brady G, MacArthur GJ, Farrell PJ. Lefu la Epstein-Barr le Burkitt lymphoma. Journal of Clinical Pathology. 2007; 60 (12): 1397-1402.
> Kapatai G, Murray P. Contribution ea kokoana-hloko ea Epstein-Barr ho li-molecular pathogenesis ea Hodgkin lymphoma. Journal of Clinical Pathology. 2007; 60 (12): 1342-1349.
> Ok CY, Papathomas TG, Medeiros LJ, Young KH. EBV-positive e fetisa B-cell lymphoma e kholo ea batho ba tsofetseng. Mali. 2013; 122 (3): 328-340.
> Univesithing ea Rockefeller. Science News. Phuputso e ncha e thusa ho hlalosa hore na ke hobane'ng ha kankere ea mali e bolaeang hangata e ama bana ba nang le malaria.