Meriana ea HIV e susumelitsoe ho Khetha Khetho ea Pele ho US
Tivicay (dolutegravir) ke setho sa integrase-inhibitor -sehlopheng sa li - antiretroviral se sebelisoang ho phekola HIV. E ne e le ea bobeli sehlopheng sa integrase inhibitors ho amoheloa ke US Food and Drug Administration (FDA).
Tivicay o ile a fuoa tumello ea li-FDA ka la 12 August, 2013, bakeng sa ho sebelisoa ho batho ba baholo hammoho le bana ba lilemo li 12 ho feta kapa ho feta ba boima ba lithane tse 40 (40kg) 'me ha ba e-s'o tšoaroe ka pele ka integrase inhibitor.
(Hona joale Tivicay ha e amohelehe bakeng sa bana ba ka tlase ho lilemo tse 12 le hoja liteko tsa meriana ea Phase III li ntse li tsoela pele ho hlahloba tšireletseho le katleho ea eona sehlopheng seo sa lilemo.)
Tivicay e boetse e le karolo ea lithethefatsi tse kileng tsa e-ba le letsatsi le leng le le leng, tse sebelisitsoeng hantle , Triumeq , tse akarelletsang meriana ea abacavir le lamivudine. Triumeq e ile ea amoheloa ke FDA ka la 22 August, 2014.
Lintlha-khōlō tsa Phuputso ea Bongaka
Thuto ea VIKING-3 e bontšitse hore Tivicay e ne e sebetsa ho 63% ea bakuli ba baholo ba hanyetsanang le lihlopha tse ngata tsa lithethefatsi tsa HIV, ho akarelletsa le integrase inhibitors Isentress (ratelgravir) le elvitegravir (e fumanoang piliseng e le 'ngoe, tekanyo ea tekanyo e kopanetsoeng ea lithethefatsi, Stribild ) .
Thuto ea SINGLE e senoletse hore bakuli ba Tivicay ba ne ba e-na le khaello e fokolang ea ho khaotsa ka lebaka la liphello tse mpe tsa lithethefatsi ho feta Atripla (tenofovir + emtricitabine + efavirenz). Ka mor'a libeke tse 48, lihlooho tse 2% tse fanoeng ka taolo ea Tivicay e fokotsoe kalafo ho fapana le 10% ea ba fumanang Atripla.
Tekanyo
- Ba baholo: 50mg tablet, hang ka letsatsi
- Batho ba baholo ba nang le tekanyetso e itseng ea integrase-inhibitor e amanang le eona : 50mg tekete, ka makhetlo a mabeli ka letsatsi
- Bana ba 12 le ho feta (boima ba 88 lbs / 40kg kapa ho feta): tekete ea 50mg, hang ka letsatsi
Ho feta moo, bakeng sa bana ba tšehetsoeng ke Sustiva (efavirenz), Aptivus (tipranavir) + Norvir (ritonavir), Lexiva (fosamprenavir) + Norvir (ritonavir), kapa rifampin, tefo ea Tivicay e 50mg, habeli ka letsatsi.
Ha e e-s'o tsejoe haeba Tivicay e atleha ho bana ba nang le ts'oaetso e amanang le integrase inhibitor.
Tsamaiso ea lithethefatsi
Tivicay e ka nkoa ka ntle kapa e se na lijo, le ka nako efe kapa efe ea letsatsi.
Liphello tse Tloaelehileng
Litla-morao tse tloaelehileng ka ho fetisisa (tse hlahang ka 2% kapa tse ka tlaase ho linyeoe) ke:
- Ho tsieleha
- Hlooho ea hlooho
- Sehlōhō
- Nausea
Litšebelisano le lithethefatsi kapa ho se lumellane
Tikosyn (dofetilide), e sebelisetsoang ho phekola arrhythmia (ho sa tloaelehe ha pelo), e hanyetsanoa bakeng sa ho sebelisoa le Tivicay.
E le ho qoba ho sebelisana ha lithethefatsi le lithethefatsi, eletsa ngaka ea hau hore na o noa meriana e fe kapa e meng:
- Meriana e thibelang li-antiretroviral: Sustiva (efavirenz), Intelence (etravirine), Viramun (nevirapine), hammoho le motsoako oa Lexiva (fosamprenavir) + Norvir (ritonavir), kapa Aptivus (tipranavir) + Norvir (ritonavir)
- Meriana ea ho itšireletsa: Trileptal (oxcarbazepine), Dilantin (phenytoin), Phenytek (phenytoin), Luminal (phenobarbital), kapa li-drug-carbamazepine tse thehiloeng Bibeleng, tse kang Carbatrol, Equetro, Tegretol, Teril, kapa Epitol
- Li-antibiotics tse thehiloeng Rifampin: Rifadan, Rifater, Rifamate, Rimactane
- Meriana ea lefu la tsoekere ea Metformin: Fortamet, Glucophage, Glumetza, Riomet
- Mokhoakho oa St. John's
Tlhokomelo
- Bakuli ba nang le bothata ba ho itšoara ka mor'a hore ba qale Tivicay ba lokela ho iteanya le ngaka hang-hang . Kalafo e lokela ho emisoa 'me phekolo ea meriana e batlehe haeba lebelo le tsamaisana le feberu, mesifa kapa maqeba a kopantsoeng, marabele kapa liso, ho khubelu kapa ho ruruha ha mahlo, ho ruruha ha sefahleho kapa molomo, kapa mathata a phefumoloho. Bakuli ba neng ba kile ba e-ba le tšoaetso ea tšoaetso ea Tivicay ha baa lokela ho tsosoa hape ka lithethefatsi ka mora ho rarolla matšoao.
- Tivicay e lokela ho nkoa lihora tse peli pele ho nako kapa lihora tse tšeletseng ka mor'a ho nka li-antacids kapa li-laxative tse nang le aluminium kapa li-magnesium, tšepe ea tšepe e tlatsetsang, khalsiamo e tlatsitsoeng, meriana e tsitsitsoeng kapa Carafate (sucralfate) e sebelisang ho phekola lisosa tsa duodenal.
- Tsebisa ngaka ea hao ho boemo leha e le bofe bo sebetsang ba sebete pele u qala Tivicay. Ho ka 'na ha e-ba le kotsi e eketsehileng ea mathata a sebete ho ba bang, haholo-holo bakeng sa batho ba nang le lefu la sebete la mofuta oa B (HVB), lefu la sebete la mofuta oa H (HCV) kapa ho se sebetse ha sebete pele ho nako. Li-enzyme tsa sebete li lokela ho hlahlojoa khafetsa e le karolo ea liteko tsa motho tse tloaelehileng tsa mali tse nkang Tivicay.
> Mehloli:
Laebrari ea Sechaba ea Meriana ea US. "Letlapa la TIVICAY (dolutegravir sodium), filimi e koetsoe." Bethesda, Maryland; e ntlafalitsoeng ka August 2013.
ViiV Healthcare. "ViiV Healthcare e amohela tumello ea FDA bakeng sa Triumeq." London, Engelane; tokomane ea khatiso e fanoeng ka la 22 August 2014.
Walmsley S .; Antela, A .; Clumeck, N .; et al. "Dolutegravir (DTG; S / GSK1349572) + bacavir / lamivudine hang ha letsatsi le leng le le leng e bapisoa le tenofovir / emtricitabine / efavirenz: liphetho tsa libeke tse 48 - SINGLE (ING114467)." 52nd Interscience Conference mabapi le likokoana-hloko tsa antimicrobial le chemotherapy. San Francisco; La 9-12 September, 2012; Sephetho sa H-556b.
Nichols, G .; Grossberg, R .; Lazzarin, A .; et al. " Ho Etsa Likokoana-hloko tsa Dolutegravir ho Lihlooho le ho Hlōleha Setulong se thehiloeng ho Integrase Inhibitor: Beke ea 24 Sekhahla sa 3 se Tsoang ho VIKING-3." Kopano ea 11 ea Machaba ea Phekolo ea Meriana ho HIV Infection (HIV11). Glasgow, Scotland; La 11-15 November, 2012; Sekhetho O232.