Litlhaloso tsa bohlokoa tsa ho sebelisa lithethefatsi
Stribild (eo hape e tsejoang ka ho tloaelehileng e le pilisi ea Quad) ke tablet-e le 'ngoe, tekanyo e tsitsitseng ea meriana e nang le li-antiretroviral tse' nè tse sebelisetsoang ho phekola HIV:
- tenofovir , nucleotide reverse transcriptase inhibitor
- emtricitabine, bobeli ba nucleotide reverse transcriptase inhibitor
- elvitegravir , integrase inhibitor
- motsoako oa kokoana-hloko , kokoana-hloko ea HIV
Stribild e ile ea amoheloa ke US Food and Drug Administration (FDA) ka August 2012 bakeng sa tšebeliso ea batho ba baholo ba lilemo li 18 le ho feta ba qalang li-antiretrovirals ka lekhetlo la pele, kapa ba nang le ts'oaetso ea HIV ba tlokotsing meriana e sa bonahaleng.
Ts'ireletseho le katleho ea Stribild li ile tsa hlahlojoa ho bakuli ba baholo ba 1 408 bao pele ba neng ba sa sebetsane le bona litsing tsa meriana tse peli tse se nang bokooa, tse ileng tsa etsa qeto ea hore Stribild e ne e le e sebetsang hantle ebile e mamelloa hantle joaloka Atripla , e leng lithethefatsi tse ling tse sa tsitsitseng tse entsoeng ka tenofovir, emtricitabine le efavirenz .
Ka 2016, phetoho e ncha ea lithethefatsi e bitsoang Genvoya e ne e lumelloa ke FDA, e nkela tenofovir sebaka se ncha ea lithethefatsi e bitsoang tenofovir alafenamide (TAF), e tsejoang hore e na le litla-morao tse fokolang le litekanyetso tse tlaase tsa lithethefatsi.
Ho thehoa
Stribild ke letlapa le tala, le bolelele ba filimi, le nang le 150mg ea elvitegravir, 150mg ea cobicistat, 200mg ea emtricitabine le 300mg ea tenofovir. E na le "GSI" ka lehlakoreng le leng 'me e na le "1" e nang le sekoere ho e' ngoe.
Tekanyo
Letlapa le le leng le letsatsi le nkiloe ka lijo. Stribild ha ea lokela ho nkoa ka lithethefatsi leha e le life tse sebelisoang ho tšoara HIV.
Litla-morao
Litla-morao tse 'maloa tsa lithethefatsi li' nile tsa hlokomeloa ho bakuli ba nkang Stribild. Liketsahalo tse bohloko ka ho fetisisa, tse tlalehiloeng bakuli ba 7% kapa ho feta, e ne e le:
- Nausea
- Letšollo
- Hlooho ea hlooho
- Litoro tse sa tloaelehang
Litšebelisano le lithethefatsi kapa ho se lumellane
Stribild ha ea lokela ho nkoa ka lithethefatsi tse latelang kapa li-supplement:
- Meriana ea Anti-migraine: Cafergot, Migergot, Ergostat, Medihaler Ergotamine, Wigraine, Wigrettes, Ergotrate, Methergine, DHE 45
- Meriana ea Anti-psychotic: Orap
- Meriana ea li-cholesterol e theohelang li-statin: Zocor, Simcor, Vytorin, Mevacor, Mohanyetsi, Altoprev, Mevacor
- Meriana ea Hepatitis B: Hepsera, Preveon
- Prokinetic agents: Propulsid, Propulsid Quicksolv
- Meriana ea li-prostate: Uroxatral
- Phekolo ea meriana e bakoang ke khatello ea meriana: Revatio
- Meriana e thibelang lefuba ea Rifampin: Mycobutin, Rifater, Rifamate, Rimactane, Rifadin, Priftin
- Litloaelo: Ho latela, Halcion
- Mokhoakho oa St. John's
Tlhokomelo
Stribild e ka 'na ea e-ba bothata ho batho ba nang le bothata ba mathata a liphio. Ka kopo o tsebisa ngaka ea hau hore na u na le lintlha tse joalo pele u nka Stribild. Mosebetsi oa liphio o lokela ho hlahlojoa hangata ho bakuli ba Stribild. Qoba ho phekoloa ho bakuli ba lumelloang ho etsa hore li-creatinine li fane ka tlase ho 50mL / metsotso. Lithethefatsi tsa Nephtotoxic ha lia lokela ho ts'oaroa le Stribild.
Mefuta e 'meli ea mafolofolo a Stribild (tenofovir, emtricitabine) le eona e sebetsa khahlanong le tšoaetso ea lefu la hepatitis B (HBV) . Haeba u na le HBV mme u khaotsa ho nka Stribild, u tla lokela ho hlahloba lik'hemik'hale tsa sebete tsa hao ka likhoeli tse 'maloa ha ho emisa ka linako tse ling ho ka etsa hore HBV e fokotsehe.
Joalokaha ho le joalo ka mela eohle ea meriana ea li-antiretroviral, li-NRTI tse Stribild li amahanngoa le kotsi e nyenyane ea lactic acidosis, hammoho le mathata a sebete.
Haeba u na le phefumoloho e khutšoanyane; ho nyefutsa le ho hlatsa; ho hlomoha kapa ho sa lebelloa ka mpeng; lethargy le mokhathala; bofokoli matsohong le maotong; kapa mosehla oa letlalo le / kapa mahlo, mo bitsa ngaka hang-hang. Lekhasi la acidtic, haholo-holo, le ka 'na la bolaea haeba le sa laoloe.
Lisebelisoa:
US Administration of Drug and Drug Administration. "FDA e amohela pilisi e kopanetsoeng bakeng sa phekolo ea HIV ho bakuli ba bang." Silver Spring, Maryland; tokomane ea phatlalatso e fanoeng ka la 27 August, 2012.
Wohl, D .; Cohen, C ;; Gallant, J .; et al. "Elvitegravir / cobicistat / emtricitabine / tenofovir DF (STB) e na le katleho ea nako e telele 'me e khetholla polokeho ea nako e telele le ho mamelleha ho fapana le efavirenz / emtricitabine / tenofovir DF (ATR) bekeng ea 144 ho bakuli ba nang le tšoaetso ea HIV." 53rd Interscience Seboka sa Mahlaseli a Antimicrobial le Chemotherapy (ICAAC). Denver, Colorado, la 11 September, 1013; e hlakileng H-672a.
Shalit, P .; Gallant, J .; Mills, A .; et al. "Tlhokofatso ea nako e telele ea elvitegravir / cobicistat / emtricitabine / tenofovir DF ha e bapisoa le efavirenz / emtricitabine / tenofovir DF kapa atazanavir-enhanced atazanavir plus emtricitabine / tenofovir DF litabeng tse nang le tšoaetso ea HIV-1." 53rd Interscience Seboka sa Mahlaseli a Antimicrobial le Chemotherapy (ICAAC). Denver, Colorado; La 11 September, 2013; e hlakileng H-671.