Ho ea ka National Cancer Institute, kankere ea matsoele e hlaselang e ama mosali a le mong ho ba robeli ba United States, 'me hoo e ka bang karolo ea 5 lekholong ho ea ho karolo ea 10 lekholong ea lik'hemik'hale tsa matsoele e ba lefa.
Hona joale, batho ba bangata ba tloaelane le liphetoho tsa liphatsa tsa lefutso tsa BRCA1 le BRCA2, tse fetoletsoeng ke liphatsa tsa lefutso tsa lefutso-kapa tse sa tloaelehang DNA-e leng ho eketsa kotsi ea ho ba le kankere ea matsoele.
Ho ea ka lipalo-palo tse tsoang ho National Cancer Institute, ka lilemo tse 70, karolo ea 55 ho ea ho 65 lekholong ea basali ba futsitseng phetoho ea liphatsa tsa lefutso tsa BRCA1 le hoo e ka bang liphesente tse 45 tsa basali ba futsitseng BRCA2 liphatsa tsa lefutso li tla fumanoa li e-na le kankere ea matsoele. Ho fihlela joale, liphetoho tsa BRCA1 le BRCA2 li etsa karolo ea 20 ho ea ho karolo ea 25 lekholong ea lik'hemik'hale tsohle tsa mafu.
Empa lintlha tsena feela li tlaleha karolo e nyenyane ea basali ba tla hlaolela lefu lena. Na bo-rasaense ba na le kamano e haufi le ho tseba hore na liphatsa tsa lefutso tse ling tse ling li ka etsa'ng ho ntlafatsa kankere ea matsoele? Ha e le hantle, li joalo.
Lithuto tse peli li Shed Light ho Liphetoho tse Ncha tsa Liphatsa tsa lefutso
Ka October 2017, lithuto tse peli li ile tsa phatlalatsoa likhatisong tsa Nature le Nature Genetics , ka ho latellana, tse ileng tsa tlaleha ka se fumanoeng ke liphetoho tse 72 tse sa tsejoeng tsa liphatsa tsa lefutso tse eketsang kotsi ea mosali ea ho tšoaroa ke kankere ea matsoele. Sehlopha sa machaba, se neng se khannela lithuto tsena, se bitsoa OncoArray Consortium, 'me sa bokella bafuputsi ba fetang 500 ba tsoang litsing tse fetang 300 lefatšeng lohle-thuto ena e ntse e thoholetsoa e le thuto ea kankere ea matsoele ka ho fetisisa historing.
Ho bokella boitsebiso ba thuto ena, bafuputsi ba ile ba hlahloba boitsebiso ba liphatsa tsa lefutso ba basali ba 275 000-ba 146 000 ba bona ba neng ba fumanoe ba tšoeroe ke kankere ea matsoele. Boitsebiso bona bo boholo bo thusa bo-rasaense hore ba fumane lits'oaetso tse ncha tse bakang basali ba bang kankere ea matsoele 'me li ka fana ka leseli la hore na ke hobane'ng ha mefuta e meng ea kankere e thata ho feta ho ba bang.
Tse ling tsa tse ling mabapi le lipatlisiso tsena ke tse latelang:
Phuputsong e 'meli, bafuputsi ba fumane liphetoho tse ling tse 72 tse ncha tse hlahisang kankere ea matsoele.
Ho fumana mefuta ena ea liphatsa tsa lefutso, bafuputsi ba ile ba hlahloba DNA ea likarolo tsa mali ho basali ba amehang thutong; hoo e batlang e le halofo e ne e fumane lefu la kankere ea matsoele. DNA e ne e lekanngoa libakeng tse fetang limilione tse 10 ho pholletsa le genome ho batla lintlha tse poteletseng mabapi le hore na DNA ho basali ba neng ba fumanoe e e-na le kankere ea matsoele e fapane ka tsela e fapaneng le ea DNA ho ba neng ba sa fumanoa.
Har'a lihlopha tse 72 tseo bafuputsi ba neng ba li fumane, tse 65 tsa tsona li ne li amana le kotsi e eketsehileng ea ho ba le kankere ea matsoele.
Mefuta e supileng e setseng e amahanngoa le kotsi e phahameng ea ho hlahisa kankere ea matsoele e sa amoheleheng ea li-hormone. American Cancer Society e hlalosa mofuta ona oa kankere ea matsoele ka ho re, "Kankere ea matsoele ea hormone (kapa hormone-negative) ha e na li-receptor tsa estrogen kapa li-progesterone. Kalafo e nang le lithethefatsi tsa meriana ea hormone ha e na thuso ho tsena kankere. "Ka mantsoe a mang, tsena liphatsa tsa lefutso li ka baka mofuta oa kankere ea matsoele eo lithethefatsi le litlhare tsa hormone, joaloka Tamoxifen kapa Femara, li ke keng tsa lekane.
Ha e kenyelitsoe linthong tse fetileng tse fumanoeng, liphuputso tsena tse ncha li tlisa palo e feletseng ea liphetoho tsa lefutso tse amanang le kotsi e eketsehileng ea ho hlahisa kankere ea matsoele ho pota 180.
Joalokaha ho boletsoe phuputsong, mefuta e sa tsoa fumanoa ea liphatsa tsa lefutso e eketsa kotsi ea mosali ea ho tšoaroa ke kankere ea matsoele ka hoo e batlang e le karolo ea 5 ho ea ho karolo ea 10 lekholong. Le hoja liphetoho tsena li se na tšusumetso e kang BRCA1 le BRCA2, lipatlisiso li bontša hore mefuta ena e nyenyane e ka ba le phello e matla ho basali ba nang le bona, e leng ho ka eketsang monyetla oa ho hlaolela lefu lena.
Seo se Boleloang ke Basali ba Kotsing ea ho Hlahisa Hereditary Cancer Breast
Breastcancer.org, mokhatlo o se nang phaello o ikemiselitseng ho bokella tlhahisoleseding le ho theha sechaba bakeng sa ba anngoeng ke kankere ea matsoele, o arolelana le boitsebiso bona, "Batho ba bangata ba hlahisang kankere ea matsoele ha ba na nalane ea malapa.
Leha ho le joalo, ha histori e matla ea lelapa ea kankere ea matsoele le / kapa ea 'mele e teng, ho ka' na ha e-ba le lebaka la ho lumela hore motho o futsitse mofuta o sa tloaelehang o amanang le kotsing ea kankere e phahameng ea matsoele. Batho ba bang ba khetha ho etsa liteko tsa liphatsa tsa lefutso ho fumana. Tlhahlobo ea liphatsa tsa lefutso e akarelletsa ho fana ka mohlala oa mali kapa masapo o ka hlahlojoang ho nka mefuta efe kapa efe e sa tloaelehang liphatseng tsena tsa lefutso. "
Hona joale, liteko tse tloaelehileng haholo tsa liphatsa tsa lefutso tsa lefu lena ke liphetoho tsa lefutso tsa BRCA1 le BRCA2. Empa ha saense e hlahisa mefuta e meng ea liphatsa tsa lefutso tse amanang le kankere ea matsoele, ngaka ea hau e ka 'na ea nkhothaletsa ho hlahlojoa hape ka moeletsi oa liphatsa tsa lefutso . Haeba pale ea hau ea botho kapa ea lelapa e fana ka maikutlo a hore u ka ba motlatsi oa lintho tse ling tse sa tloaelehang tsa liphatsa tsa lefutso, lehlakore le lengata la liphatsa tsa lefutso le ka ba molemo ho uena. Ha tsoelo-pele tšimong ea liphatsa tsa lefutso e ntse e tsoela pele, mekhoa e nepahetseng ea ho hlahloba e tla lumella hore ho fumanoe lisosa tsa kotsing ea matsoele pele ho nako, mokhoa o mong le o mong oa tlhokomelo, le lits'ebetso tse molemo tsa phekolo.
Na ho na le Mehato ea Thibelo Basali ba ka e Nka?
Breastcancer.org e khothalletsa hore basali ba hlokomelang hore ba na le phetoho ea liphatsa tsa lefutso tse amanang le kankere ea matsoele ba nahane ka ho sebelisa mehato e latelang e thibelang kotsi :
Beha boima boemong bo botle
E-ba le lenaneo le tloaelehileng la ho ikoetlisa
Qoba ho tsuba
Nahana ka ho fokotsa kapa ho felisa joala
Ja lijo tse nang le limatlafatsi
Maqheka a mangata a thibelang mabifi a ka kenyelletsa:
Qala ho hlahloba kankere ea matsoele ea lefa ka nako e sa tsoa feta, ho itšetlehile ka histori ea lelapa la mosali
Litlhare tsa Hormonal
- Bothata bo bakoang ke ho bolaoa ke mafu, kapa ho tlosoa ho buuoa ha matsoele a phetseng hantle
Lentsoe le Tsoang ho
Histori ea lelapa ka leng le e 'ngoe e ikhetha, kahoo ha ho na mokhoa o lekanang le o mong oa ho thibela kapa ho phekola kankere ea matsoele. Haeba u kotsing ea ho hlaseloa ke kankere ea matsoele, leka ho bua le ngaka ea hao ka mokhoa oa ho fokotsa kotsi ea lefu lena, mme ha ho hlokahala, mehato e loketseng ea bongaka e fumanehang ho uena.
Haeba u iphumana u talimane le tšabo e tšosang ea kankere ea matsoele, itšetlehe ka ba bang bakeng sa tšehetso. Sechaba sa kankere ea matsoele se ntse se atleha, 'me se tletse basali ba nang le botsitso ka ho fetisisa bao u tla ba le bona. Ba tla u khothatsa tseleng ea hau. Ho feta moo, ho ba le tšehetso e eketsehileng ho ka fokotsa maikutlo a ho ikarola a ka 'nang a hlaha ka lefu la kankere ea matsoele.
> Mehloli:
> Sefuba sa kankere ea kankere ea boemo ba mokokotlo oa kankere ea kankere. Websaeteng ea Mokhatlo oa Amerika oa Kankere. https://www.cancer.org/cancer/breast-cancer/understanding-a-breast-cancer-diagnosis/breast-cancer-hormone-receptor-status.html
> Kankere Stat Facts: Kankere ea Lebese la Basali. Websaete ea National Cancer Institute. https://seer.cancer.gov/statfacts/html/breast.html
> Michailidou K, Lindstrom S, Dennis J, et al. Tlhahlobo ea mokhatlo e tsebahatsa tšoaetso e ncha ea kankere ea matsoele ea 65. Tlhaho. 2017. etsa: 10.1038 / nature24284
> Milne RL, Kuchenbaecker, KB, Michailidou K, et al. Ho khetholla mefuta e leshome e fapaneng e amanang le kotsi ea kankere ea letsoele ea letsoele ea estrogen-receptor. Nature Genetics. 2017. etsa: 10.1038 / ng.3785
> Thuto e fumana 72 Liphetoho tse ncha tsa liphatsa tsa mafu tse amanang le kankere ea matsoele. Websaeteng ea Breastcancer.org. http://www.breastcancer.org/research-news/72-new-genetic-mutations-linked-to-bc-found