Libaktheria tse fanang ka likhomo li ka ba le karolo ho boloetse ba Crohn
Lihlopha tse fokolang le indasteri ea lebese li lebisa tlhokomelo ho lefu le amang 1 mehlape e meng le e meng e mehlano ea likhomo United States 'me e hlalosoa hore e amana le lefu la Crohn. E ntse e sa tsejoe haeba ho na le, kannete ho na le kamano pakeng tsa libaktheria tse fumanoang ho tšoaetsa likhomo le maloetse a hlaselang mafu (IBD) . Leha ho le joalo, ke taba e thahasellisang haholo ho bakuli le bafuputsi.
Sefu sa Johne ke Eng?
Matšoao a Johne's (YO-nees) a bakoa ke baktheria ea Mycobacterium paratuberculosis 'me ho hakanyetsoa hore e lefella lefapha la lebese liranta tse limilione tse 200 ho ea ho liranta tse limilione tse 250 ka selemo. Ho felisa Johne ho ne ho tla kenyelletsa teko ea ho lemoha likhomo tse kulang e le ho li felisa. Ho hakanngoa hore boholo ba li-68% tsa likhomo tsa lebese li tšoaelitsoe ke lefu la Johne.
Khomo e nang le tšoaetso e bontša matšoao a letšollo le ho lahleheloa ke 'mele ha baktheria e hlasela li-leum. Hangata feberu kapa bohloko ba mpa (ho thata ho netefatsa liphoofolo) hape ke matšoao. Ha lefu lena le ntse le tsoela pele, karolo e 'ngoe ea tšebetso ea lijo e ama. Qetellong, libaktheria li hasana ho lymph nodes le mali. Ha khomo e nang le tšoaetso e fumanoa, hangata e romeloa ho hlajoa - ke hore, e fetoha steaks le hamburger.
Kamoo Cattle e Amehang Kateng
Libaktheria li etsa hore Johne a tšolloe ke khomo e nang le tšoaetso ka lebese la hae. Mokhoa oa hona joale oa phallo o thehiloe ho Mocheso o phahameng, nako e khutšoanyane (HTST).
Sena se bolela hore lebese le futhumetse ho 72º Celsius (162º F) ka metsotsoana e 15. Nako ea metsotsoana e 15 e bontšitsoe hore ha e lekaneng ho bolaea libaktheria tsohle tsa paratuberculosis, tse nang le lerako le lekaneng la tšepe. Ka lebaka leo, paratuberculosis e ka phela ka mokhoa oa ho phalla 'me e be ka likotone tsa lebese lijong tsa litekete.
Ha e le hantle, bafuputsi ba fumane hore lebese la li-25% lebiseleng la mabenkele le bohareng le ka boroa Engelane le na le DNA ea paratuberculosis.
Mathata a Johne ha a lekanyetsoe ke likhomo feela. E ka boetse ea tšoaetsa liphoofolo tse ling tse kang linku, litloholo le ho latela litsebi tsa saense tsa Scottish, mebutlanyana, liphokojoe, li-stoe, li-weasel, litoeba le li-voles. Ho boleloa hore liphoofolo tsena li tšoaroa ke lefu lena ho tsoa liphoofolong tse nang le tšoaetso, empa ha ho tsejoe hore na li ka fetisetsa libaktheria ho liphoofolo.
Hokahanngoa le Mafu a Crohn
Khopolo ea tlhōlisano ke hore paratuberculosis e ka boela ea baka lefu la Crohn bathong. Ka 1984, mefuta e sa ratoang ea Mycobacterium e ne e arohane le bakuli ba bararo ba Crohn. Ka 1991 ho ile ha e-ba bonolo ho tsebahatsa mefuta ena e meraro kaha bohle ba ba M paratuberculosis. Ka 1992 ho ile ha etsoa phuputso e 'ngoe ka masela a mala a neng a tlosoa nakong ea ho buuoa ho tloha Crohn's, e leng 23 masapo a kulang, hammoho le bakuli ba 40 bao e seng basebetsi. Matsoalo a 65% a mokuli a Crohn a na le M paratuberculosis , e fapaneng le 12.5% feela ea bakuli bao e seng ba-IBD. Bafuputsi ba ile ba etsa qeto ea hore M paratuberculosis e "bapala karolo ea ho iphelisa ka maemong a mang a lefu la Crohn."
Ka 1998 Setsi sa Sechaba sa ho Tsamaea ha Meriana le mafu a tšoaetsanoang (NIAID) se ile sa tšoara seboka sa ho nka lipatlisiso bakeng sa lipatlisiso tse eketsehileng mabapi le kamano pakeng tsa M paratuberculosis le lefu la Crohn.
Barupeluoa ba ile ba lumela hore bopaki bo eketsehileng ba saense boa hlokahala ho paka kapa ho hanyetsa hore M paratuberculosis e ka baka maloetse bathong. Lintlha tse 'maloa tsa lipatlisiso tse ling li ile tsa fumanoa.
Mehato e latelang ho Patlisiso
Sehlopha sa bobuelli ba mokuli, Mokhatlo oa Tlhokomeliso le Patlisiso ea Paratuberculosis, Inc (PARA), e phethile karolo ea bohlokoa ho lebisa tlhokomelo tabeng ena. Ka March 2001, Cheryl Miller, Motsamaisi-Motsamaisi-Motsamaisi oa PARA, o ile a fana ka bopaki ka pel'a Komiti ea Likamano ea Ntlo ea Lekhotla la Mesebetsi ea Bophelo, Bophelo le Litšebeletso tsa Botho, le Thuto e ba kōpa hore ba behelle ka thōko chelete bakeng sa ho batlisisa lefu la Crohn.
Liphetoho tsena ke sepheo sa lipatlisiso tse ling ka lebaka la sesosa sa lefu la Crohn. Hona joale ho nahanoa hore IBD ha e le hantle ke makholo a maloetse, 'me ho na le lisosa tse ngata tse fapaneng.
Lisebelisoa:
Chiodini RJ, Van Kruiningen HJ, Merkal RS, Thayer WR, le Coutu JA. "Litšoaneleho tsa mefuta e mengata ea mescobacterium e sa ratoang ka ntle ho bakuli ba nang le lefu la Crohn's." J Clin Microbiol . Nov 1984 20: 966-971.
Collins M, Manning E. "Epidemiology." Setsi sa Boitsebiso sa Johne, Univesithing ea Wisconsin. 3 Mar 2010.
Fana IR, Ball HJ, Rowe MT. "Phello ea mahlaseli a phahameng a pasteurization, 'me le nako e telele e tšoere likhato tse 72 tsa C, ho se sebetse ha Mycobacterium paratuberculosis lebese." Mangolo a sebelisitsoeng Microbiology . Jun 1999 28: 461-465.
Millar D, et al. "IS900 PCR ho fumana Mycobacterium paratuberculosis Litlhapong tsa Lichelete tsa Lebese Lekholong le Phelang la Khomo Engelane le Wales." Tlhahlobo ea Microbiology e sebelisitsoeng le ea tikoloho . Sept 1996 62: 3446-3452. 12 Mar 2012.
Moss MT, Green EP, Tizard ML, Malik ZP, Hermon-Taylor J. "Ho fumanoa ka ho khethehileng ha Mycobacterium paratuberculosis ka DNA e kopantsoeng le sekhechana sa insler element IS900." Ho tloha ka 1991; 32: 395-398.
Naser SA, Sagramsingh SR, Naser AS, Thanigachalam S. "Mycobacterium avium subspecies paratuberculosis e baka lefu la Crohn ho bakuli ba bang ba tšoeroeng ke lefu lena." World Journal of Gastroenterology : WJG. 2014; 20 (23): 7403-7415.
Sanderson JD, Moss MT, Tizard MLV, Hermon-Taylor. "DNA ea mycobacterium paratuberculosis e entsoeng ke lefu la Crohn's disease." Gut 1992; 33: 890-896.