Ho ntse ho le joalo, ha ho na pheko ea mafu a Parkinson's (PD). Empa tsoelo-pele e kh ¯ ol ¯ o e sa tsoa etsahala ho batla pheko. Lilemong tse 10 tse fetileng, mefuta e 'maloa ea PD e fumanoeng e futsanehile ' me liphatsa tsa lefutso tse ikarabellang bakeng sa mefuta ena ea PD li 'nile tsa fumanoa le ho ithutoa. Ho sibolloa hona ha liphatsa tsa lefutso tsa lefu lena ho ka nkoa e le ts'ebetso e hlahelletseng ho batla pheko ea PD hobane bo-rasaense ba ka sebelisa liphatsa tsa lefutso tse botsoang hore ba batle sesosa sa sesosa sa lefu lena.
Bakeng sa tlaleho, liphatsa tsa lefutso tse bakang mefuta e fapaneng ea lefu lena li kenyelletsa liphetoho tse fetohileng (liphetoho lik'hemik'hale tsa liphatsa tsa lefutso) kapa liphetoho tsa likarolo tsa liphatsa tsa lefutso. Liphatsa tsa lefutso tse tlas'a lipatlisiso li kenyeletsa liphatsa tsa alpha-synuclein, lefapha la ubiquitin-C-terminal hydrolase-L1 (UCH-L1), liphatsa tsa lefutso tse nang le leucine-rich repeat kinase (LRRK) 2, le Parkin, PINK1, DJ-1 le Liphatsa tsa lefutso tsa ATPase13A2.
Hona joale, ho hlakile hore mabitso ana a liphatsa tsa lefutso a ka 'na a utloahala eka ke puo e se nang thuso ho uena. Empa kea u tiisetsa hore ho fumanoa ha bona ho tla lebisa tsoelo-pele e khōlō ho batla pheko bakeng sa PD.
Ho lokisa Litšitiso Tsa Liphatsa tsa lefutso Tse ka Bakang Mafu a Parkinson
Hona joale rea tseba hore mefuta e itseng ea bofokoli ba liphatsa tsa lefutso liphatsa tse itseng tsa lefutso e ka baka PD. Seo se bolela hore haeba re khona ho lokisa liphatsa tsa lefutso tseo re li nahanang, re ka thibela kapa hona ho phekola lefu lena. Ho bile le mosebetsi o mong sebakeng sena mme mehaho e meng e thabisang e ntse e tsoela pele.
Sebaka sena sa lipatlisiso se bitsoa phekolo ea lefutso kapa meriana ea genomic. Ho fihlela joale, kenyelletso ea bokong ea rat (rat e senyelitseng lisele tsa dopamine) ea moemeli oa likokoana-hloko o hlalosang Park1 ea batho ka setšoantšo sa palo ea PD e ile ea fella ka tšireletso ho lahleheloa ke sele ea dopamine le boitšoaro bo tšoanang le ba Parkinson phaleng.
Ha e le hantle, ho ntlafatsa mekhoa ea litlhapi tsa PD ke tsela e telele ea ho bontša hore ntho e tšoanang e ka etsahala bokong ba motho.
Kamoo Matšoao a Liphatsa Tsa Lefutso a ka Etsang Hore Mafu a Harmagedone a Mafu a Hloko
Liphuputso tsa liphoso tsa lefutso tse bakang mefuta e mengata ea PD e bontšitse hore PD e ka fella ha e 'ngoe ea mekhoa e mengata e fokotseha. Mekhoa ena e qetella e lebisa tšenyo ea sele bokong. Mokhoa oa pele o ameha ka ho senyeha ha mekhoa ea ho laola boleng bakeng sa ho sebetsana le tlhahiso ea protheine bokong. Liprotheine ke mohaho oa lisele tsohle tsa 'meleng oa hau.
Kahoo ha mokhoa oa ho hlahisa liprotheine o theoha, likokoana-hloko tse nyenyane tsa liprotheine tse entsoeng hampe li qala ho bokella liseleng, 'me tabeng ea alpha-synuclein, li tlatsetsa ho thehoa ha ' mele ea Lewy . Litsebi tsa lipatlisiso li ntse li hlahloba karolo ea lihlopha tsena tsa Lewy ho nts'etsong ha lefu la Parkinson, empa khopolo e 'ngoe e fana ka maikutlo a hore protheine aggregation e kena-kenana le ts'ebetso e tloaelehileng ea sele le ho se sebetse hantle. Bothata bo bong bo bakoang ke bofokoli ba liphatsa tsa lefutso bo lebisang mefuteng ea PD e na le ho se sebetse ha mitochondrial. Mitochondria e na le li-organelle tse nyenyane liseleng tsa hau tse ikarabellang ho hlahisa matla bakeng sa 'mele.
Tlhahiso ea li-radicals mahala - limolek'hule tse nyenyane tse ka lematsang lisele tse hlahisang dopamine. Ha mitochondria e ntse e sebetsa ka mokhoa o tloaelehileng, li-radicals tse mahala li qhaqhoa le ho fokolloa. Empa ha mitochondria e sa sebetse ka mokhoa o tloaelehileng, li-radicals tsa mahala li haha bokong le ho senya lisele tse hlahisang dopamine.
Qetellong, likokoana-hloko tsa lefutso tse lebisang ho PD le tsona li fumanoe liprotheine tse bitsoang kinase. Liprotheine tsena li na le mesebetsi e mengata ka seleng, mme bafuputsi ba ntse ba leka ho utloisisa hore na liphatsa tsa lefutso li baka PD joang.
Lisebelisoa:
Denise M. Kay, Jennifer S. Montimurro le Haydeh Payami. Liphatsa tsa lefutso. Ka: Maloetse a Parkinson: Tlhahlobo le Ts'ebetso ea Meriana: Khatiso ea Bobeli E hlophisitsoeng ke Stewart A Factor, DO le William J Weiner, MD. Phatlalatso ea Bongaka ea Bongaka ba 2008.
Andrew J. Lees, setopo sa Parkinson. Neurology 2009; 72; S2-S11; Mochizuki H. Phekolo ea Gene bakeng sa lefu la Parkinson. Setsebi sa Rev Neurother. 2007 Aug; 7 (8): 957-60.