Liphello li bontša hore moriana ona o ka fokotsa lefu la Alzheimer
Ha ke rate lihlooho tse ngotseng mabapi le lefu la 'dementia le lefu la Alzheimer' . Lefu la Alzheimer ke lefu le bohloko. E tsoela pele ho sa feleng. Lithethefatsi tse amohelehang ka FDA ho phekola lefu lena joaloka Aricept, Nemenda, le Cognex ha ba etse letho ho fokotsa thupelo ea eona ea bongaka.
Boholo ba litsebi tsa methapo ea mafu bo tseba hore meriana ha e na bohlokoa ho bakuli ba bona ba lefu la Alzheimer.
Leha ho le joalo, baratuoa ba kōpa meriana ena ka tšepo ea hore meriana ena e ka thusa ka tsela e nyenyane. Qetellong, phekolo e ntle ka ho fetisisa bakeng sa ba nang le lefu la Alzheimer ke tlhokomelo e nang le kutloelo-bohloko e sa bolokang boleng ba bophelo bo botle bakeng sa motho ea nang le lefu empa hape le boleng ba bophelo bakeng sa mohlokomeli ka boeena.
Ho sa tsotellehe ts'ebeliso ea ka ea kakaretso ea ho ngola lihlooho ka lefu la Alzheimer, ke lumellane le 'na hore ke koahele lefu lena feela ha teko e meng ea lithethefatsi e fana ka maikutlo a ho fokotsa ho fokotseha ha tsebo ho ba nang le lefu lena. Morao tjena, liphello tsa pele ho liteko tse amanang le li-aducanumab tsa Biogen li bonts'a hore moriana enoa oa monoclonal o ka thibela ho tsoela pele kalafo ea lefu la Alzheimer.
Lefu la Alzheimer ke mofuta o tloaelehileng haholo oa 'dementia'. United States, ho hakanngoa hore Maamerika a limilione tse hlano a lilemo li 65 le ho feta a phela le lefu lena. Tsela ea lefu la Alzheimer e lieha ebile e ke ke ea senngoa.
Ha nako e ntse e ea, mehopolo ea Alzheimer's erodes, ho nahana le ho beha mabaka. Qetellong, motho ea nang le lefu lena le tšabehang o sitoa ho etsa le mesebetsi e bonolo le mesebetsi ea letsatsi le leng le le leng.
Tlhaloso ea rona ea hona joale bakeng sa ho kula ha lefu la Alzheimer e lekanyelitsoe "khopolo-taba ea" amyloid . " Haholo-holo, li-neurodegeneration li bakoa ke depositi ea li-peptide tsa amyloid-beta (Aß) tse li-plaque tsa maiketsetso.
Ho bokella Aß ho khanna lefu la Alzheimer's pathogenesis. Ntho e 'ngoe e tlatsetsang e akarelletsa likhahla tsa lefu la pelo tse entsoeng ka liprotheine tsa tau. Ho se leka-lekane pakeng tsa lihlahisoa tsa Aß le Aß ho lebisa tlhophisong ea likhahla tsena.
Ho tla fihlela joale, ho na le likokoana-hloko tse fapaneng tse entsoeng ho loantša lefu la Alzheimer ka ho lebisa majoe a amyloid. Ka ho khetheha, aducanumab ea anti-olase e sebetsa ka ho hlahisa phagocytosis e fanoang ke Fc-receptor ea Aß plaques. Ka mantsoe a mang, aducanumab e susumetsa li-phagocyte tsa 'mele ea rona ho cheka Aß.
Lilemong tsa morao tjena, "khopolo-taba ea" amyloid "e 'nile ea belaelloa ka botebo' me e ngotsoe ke litsebi tse ngata e le ho feta. Ha re na tumello ea kliniki bakeng sa khopolo-taba, 'me ba bangata ba lumela hore ho bokella Aß e ka' na ea e-ba karolo ea ts'ebetso e khōloanyane le e sa utloisisoeng e bakang ts'oaetso. Haholo-holo, ho ba nang le boloetse ba Alzheimer, Aß e behiloe pele ho lilemo tse 10 ho ea ho tse 15 ho fokotseha ka tsela ea ho tseba hantle, kahoo ho koala sepheo sa ho ba le kamano e bonolo le sesosa. Ho feta moo, metabolism ea proyroid procuror protein (APP) e fella ka Aß feela empa e boetse e baka likaroloana tse ling tse ka kenyang pathogenesis ea Alzheimer.
E itšetlehile ka liphello tsa nakoana tsa teko ea Phalliso ea 1b ea tlhokomelo ea bongaka ea aducanumab e bitsoang PRIME, Biogen e ikemiselitse liteko tsa meriana ea Phase 3 ea lithethefatsi.
Mona a mang a liphetho tsa nakoana:
- Kalafo e nang le aducanumab e entse hore ho be le ho fokotseha ha li-plaque tse nang le li-amyloid ho batho ba nang le lefu la Alzheimer's prodromal kapa le bonolo.
- Ho fokotsa li-plaque ho ne ho bonts'a litšoantšo ka PET, 'me ho fokotseha hona ho ne ho itšetlehile ka nako le nako.
- Ka mor'a selemo se seng sa phekolo, barupeluoa ba nang le lefu la pele la Alzheimer ba ile ba bontša hore ho fokotseha ho se nang kutloisiso ho fokolisitsoeng ho fokolisitsoeng ho latela mokhoa oa "Mini-Mental Status Examination" (MMSE) le Cognitive Dementia Rating.
- Tšireletso le mamello ea mokuli ea aducanumab e ne e amoheleha. Litholoana tse ling tse bohloko li kenyeletsa hlooho le ARIA (litšoantšo tse sa tloaelehang tse amanang le li-amyloid).
E le hore lithethefatsi tsa Alzheimer kapa meriana leha e le efe e ncha e amoheloe ke FDA, e tlameha ho feta litekong tsa meriana ea bobeli tsa Mokhahlelo oa 3. Joalokaha ho boletsoe sehloohong sa morao-rao se ngotsoeng "Liteko tsa bohlokoa tsa b-secretase inhibitors" tsa Alzheimer's "ho tloha ho Biotechnology , baetsi ba lithethefatsi ba lithethefatsi tsa Alzheimer ba potlakela litekong tsa Phase 3. Mokhoa ona o kotsi hobane liphello tse seng tsa bohlokoa tsa liteko tsa Phase 3 li tla koala ntlafatso ea lithethefatsi. Ha e le hantle, ha ho na motho ea batlang ho kenya chelete merianeng "ea secheso".
Hobane setlhare se hlōleha ho bontša liphello tsa bohlokoa tsa kliniki nakong ea teko e itseng ea Phase 3 ha e bolele hore lithethefatsi ha e sebetse. Ka mohlala, ho ka etsahala hore lithethefatsi li ka atleha meriking e fapaneng le ea ba lekiloeng. Kapa, lithethefatsi tse ling li sebetsa hantle ho batho ba itseng. Ho e-na le ho fetisetsa Rubicon le ho etsa nyeoe ea Phase 3, ke khopolo e ntle ho etsa tlhahlobo ea sekhahla sa 2 le ho utloisisa hantle lithethefatsi le liphello tsa eona. Ka lehlakoreng le leng, Biogen e entse qeto ea ho tsoela pele ka liteko tsa meriana ea Phase 3 ka lebaka la ho khothatsa liphello tsa nakoana ho tloha litekong tsa Phase 1b (tse fokolang matla).
Haeba uena kapa moratuoa oa hao a tšoeroe ke boloetse ba Alzheimer, ka kōpo bala sehlooho sena ka hare ho moelelo le ntle le tšepo ea bohata. Biogene e ntse e le nako e seng kae ea ho fumana tumello ea aducanumab, 'me re ntse re hloka liphetho tse ngata tsa kliniki. Le hoja liphello tsa pele tse mabapi le aducanumab li tšepisa, lithethefatsi tsa Alzheimer li tumme ka ho se khaotse mosebeta, 'me ha re e-s'o fumane phekolo e atlehang e le hore re fokolise tsoelo-pele ea lefu lena.
Mehloli e khethiloeng
Sehlooho se nang le sehlooho se reng "Tlhahlobo ea Mahlale a Alzheimer ea Amyloid: Tsoelo-pele le Tšepiso Tseleng ea Meriana" ka J Hardy le DJ Selkoe ba hatisitsoeng Scientific ka 2002. Ba fihletsoe ka 3/22/2015.
Ropper AH, Samuels MA, Klein JP. Khaolo ea 39. Maloetse a ts'ebetsong a Ts'ebetso ea Matšoao. Ka: Ropper AH, Samuels MA, Klein JP. eds. Adams & Victor's Principles of Neurology, 10e . New York, NY: Hill ea McGraw; 2014. E fumaneha ka la 22 March, 2015
Article e reng "Liteko tsa bohlokoa tsa ß-secretase inhibitors ka Alzheimer's Cormac Sheridan e hatisitsoeng ka Nature Biotechnology ka 2015. E fumaneha ka 3/22/2015.