Lisele tsa masapo li koaletsoe boitsebisong bo bitsoang myelin. Myelin e thusa maikutlo a motlakase ho tsamaea ka maqhubu. Multiple sclerosis (MS) ke boloetse bo tšollang motho eo 'mele o hlaselang li-sheath tsa myelin tsa boko le mokokotlo ho etsa hore bakuli ba nang le MS ba bone mathata a bonahalang, bofokoli ba mesifa, mathata a ho lemoha, joalo-joalo.
Joaloka mafu a mangata, ho lumeloa hore MS e susumetsoa ke maemo a tikoloho le liphatsa tsa lefutso.
Ka tlhahlobo e hlophisitsoeng ea December 2017 e nang le sehlooho se reng "Ho pepeseha ha lithethefatsi le kotsi ea multiple sclerosis," Yong le bangoli ba selekane ba hlahloba hore na lithethefatsi tse ngotsoeng kalafo-e leng tšusumetso ea tikoloho-li ka baka kotsi ea MS. Phuputsong ena, bafuputsi ba fumane liphuputso tse 13 tsa boleng bo phahameng bakeng sa tlhahlobo. Lithuto tsena tse 13 li ile tsa hlahloba lihlopha tse supileng tsa lithethefatsi A re shebeng tšusumetso ea sehlopha se seng le se seng sa lithethefatsi ho MS.
Amiloride
Amiloride (Midamor) ke potassium-e bolokang diuretic e sebelisoang ho phekola khatello ea meriana kapa khatello ea mali e phahameng. Ka ho khetheha, Midamor o thibela mochine oa ion o bonang acid-acid (ASIC-1). Litšoantšong tsa liphoofolo tsa MS, ASIC-1 e phahame, ho bolelang hore ho na le keketseho ea lisele tsa ASIC-1. Keketseho ea lisele e fumanoa libakeng tsa tsamaiso ea methapo e meholo e senyehileng (ie, plaques). Liphoofolo tsena, ho thibela ASIC-1 ho bontšoa ho fokotsa ts'oaetso ea mali, mokhoa o amanang le ho holofala ha bakuli ba nang le MS.
Ho sa tsotellehe ho atleha ho fokotsa tšollo ea mali liphoofolong, Yong le basebetsi-'moho le eena ba ile ba fumana hore ho ne ho se na puisano pakeng tsa tšebeliso ea Midamor le maqhubu a MS ka mohlala oa Danish. (Denmark e na le libuka tse ngata tse thehiloeng ke baahi, e leng ho nolofalletsang ho etsa lipatlisiso tsa batho ba hlahlobang bophelo bo botle ba sechaba.) Ka ho hlakileng, mohlala ona oa Sedanishe o ne o e-na le batho ba neng ba qeta nako e khutšoanyane, bao bafuputsi ba neng ba hlalosa hore ke MS e tsoetseng pele ho batho ba lilemo li 60 kapa Hape.
Tlhahiso-morao MS e ama feela karolo ea 5 lekholong ea batho ba nang le MS; ka hona, ho ka etsahala hore li fumaneha ha li sebetse ho batho ba bangata ba MS. Ka mantsoe a mang, ha ho tsejoe hore na Midamor e na le tšusumetso ea likokoana-hloko tsa MS ho batho ba nang le MS empa ba sa tsoe morao MS.
Mabapi le tlaleho e latelang, bafuputsi le bona ha baa ka ba fumana tšusumetso ea thiaude diuretics, e kang Midamor hape e sebelisetsoang ho tšoara khatello e phahameng ea mali, ho MS.
Valproic Acid
Valproic acid (Valproic) ke meriana ea anticonvulsant e sebelisoang ho phekola lefu la sethoathoa . "Valproic acid e thibela histone deacetylase e ka etsang hore ho fetoloe liprotheine tse khethehileng tse kenngoa ka seleng le ho lokisoa ha myelin," ngola Yong le bangoli ba selekane. Leha ho le joalo, ka lebaka la tlhahlobo ea litaba tsa basebetsi ba Danish, bafuputsi ha ba fumane botsoalle pakeng tsa Valproic le MS kotsing.
TNF Inhibitors
Ho ea ka American College of Rheumatology, "TNF inhibitors ke mofuta oa lithethefatsi o sebelisoang lefatšeng ka bophara ho phekola maemo a ho ruruha a kang ramatiki ea ramatiki (RA), lefu la psoriatic ramatiki, lefu la ramatiki, lefu la matšoafo (Crohn's le ulcerative colitis), ankylosing spondylitis, le li-psoriasis. Li fokotsa ho ruruha le ho emisa ho kula ha motho ka ho lebisa ntho e bakang ho ruruha e bitsoang Tumor Necrosis Factor (TNF). "
Bangoli le ba-co-author ba ile ba boela ba sheba lipatlisiso tsa batho ba Denmark ho fumana hore na ho na le mokhatlo pakeng tsa TNF inhibitors le MS. Lipatlisiso tsena ka bobeli li ile tsa hlahlojoa e bile ho hlokomeloa le ho ameha lihlopha kapa mehlala ea baahi e ileng ea lateloa ka nako.
Yong le basebetsi-'moho le eena ba ile ba fumana ho se kopane pakeng tsa phekolo le TNF inhibitors bakeng sa maloetse a bohale a ho ruruha le nts'etsopele ea MS. Ka ho khetheha, le hoja ho ne ho e-na le keketseho e mene ka kotsing ea ho hlahisa MS ho ba nang le TNF inhibitors bakeng sa maloetse a bohale, ho phahama hona ho ne ho fapane le kotsi ea menyetla e mene ea hore batho ba nang le mafu a ho ruruha ba se ba ntse ba bonahatsa liketsahalo tse kang dem.
Leha ho le joalo, bafuputsi ba fumane hore banna ba fumanang TNF inhibitors bakeng sa ramatiki le banna le basali ba fumanang TNF inhibitors bakeng sa spondylitis ea ankylosing ba ne ba le kotsing e kholo ea MS ka mor'a hore ba qale kalafo. Taba ea hore, spylylitis ea ankylosing e tloaelehile haholo ho banna.
Sepheo se seng sa lithuto tsa Danish tse hlahlobiloeng ke hore ha hoa ka ha e-ba le hore na ke mefuta efe ea TNF inhibitors e sebelisitsoeng, 'me mefuta e sa tšoaneng ea li-inhibitor tsa TNF e ama ho ruruha ka litsela tse fapaneng.
Ho ea ka Yong le ba-co-author: "Ho kopanngoa, ho hlokomeloa ha pele ho phahamisa ho ameha ka ts'ireletso ea anti-TNFα [TNF inhibitors] mabapi le kotsi ea MS, empa ho hlokahala mosebetsi o mongata. Ho tla ba le bohlokoa ho netefatsa hore na ho na le liphello life ke sehlahisoa se hlakileng kapa se ka hlahisoang sehlopheng sa phekolo eohle. "
Likokoana-hloko
Lithuto tse peli tsa ho laola likarolo-e 'ngoe UK le tse ling Denmark-li hlahloba mokhatlo pakeng tsa tšebeliso ea lithibela-mafu le MS. Tlhahlobo ea ho laola likamano e bapisa bakuli ba nang le phello kapa lefu (ke hore, linyeoe) le ba sa tsebeng (e leng, litaelo). Ka lithuto tsa bolaoli ba li-case-control, bafuputsi ba shebisisa morao ho khutlela morao ho fumana hore na ho pepeseha lintlha life tse kotsi. Liphuputsong tsa UK le Danish, linyeoe tse amang bakuli ba neng ba fumanoa ba e-na le MS, 'me kotsi ea thahasello e ne e le tšebeliso ea lithibela-mafu.
Phuputsong ea UK, bakuli ba 163 ba nang le MS ba ne ba lekana le batho ba 1523 ba se nang MS ka lebaka la lilemo, thobalano le lintlha tse ling. Bafuputsi ba fumane hore tšebeliso ea lithibela-mafu e akaretsang ha e amane le MS. Leha ho le joalo, ebang penicillin e sebelisa libeke tse fetang tse peli kapa tšebeliso ea tetracycline ka nako e fetang beke e le 'ngoe e kopantsoe le karolo ea 50 lekholong e fokotsa kotsi ea MS.
Bafuputsi ba Denmark ba ile ba leka ho pheta seo bafuputsi ba UK ba se fumaneng ba sebelisa boholo ba sampuli e boholo (liketsahalo tse 3259). Ho thahasellisang ke hore bafuputsi ba Denmark ba fumane hore mefuta e mengata ea lithibela-mafu e sebelisitsoeng e ne e amahanngoa le kotsi e phahameng ea MS-esita le bakuli ba ntseng ba nka mefuta e le 'ngoe feela ea lithibela-mafu ka matsatsi a supileng. Taba ea hore mefuta e mengata ea tšebeliso ea lithibela-mafu e amahanngoa le MS e bonahala e bontša hore tšoaetso ea sebele-eseng lithibela-mafu-e ne e amana le nts'etsopele ea MS.
Ka kakaretso, ho bonahala eka lithibela-mafu ha li amane le MS ha li hlahlojoa haholo, empa lipatlisiso tse ling li lokela ho etsoa.
Inhaled Beta2-adrenergic Receptor Agonists
Fenoterol ea lithethefatsi (Berotec N) le salbutamol (ProAir HFA) ka bobeli ba kenyelletsoa ke li-agonists tse khutšoanyane tsa beta2-adrenergic receptor tse sebelisetsoang ho phekola lefu la asthma le boloetse bo sa foleng ba pulmonary pulmonary. Lefapheng la ho laola lik'homphieutha, bafuputsi ba Taiwan ba ile ba hlahloba hore na lithethefatsi tsena li susumeletse kotsi ea MS. Ba fumane hore le hoja ho ne ho e-na le menyetla e fokolang ea MS ho ba ntseng ba nka Berotec N, kotsi ea ho hlahisa MS ha e amane le ProAir HFA.
Bafuputsi ba Taiwan ba etsa tlhahiso ea hore Berotec N e ka ba le tšireletso ka lebaka la bokhoni ba eona ba ho thibela moloko oa superoxide le degranulation. Kamoo ho bonahalang kateng, ProAir HFA ha e ntle ho etsa lintho tsena; ka hona, ha e na tšireletso ea letho.
Ho phaella moo, ha u nahana ka li-agonist tse nyenyane tse sebetsanang le beta2-adrenergic joaloka sehlopha, ba-Yong le bangoli ba selekane ba bolela se latelang: "Li-agonists tse khutšoanyane tsa beta2-adrenergic ke li-bronchodilator tse thibelang li-interleukin-12, e leng cytokine e etsang hore T cell e fapane lisebelisuoa tse matlafatsang T li thusa lisele tse 1. "Taba, litsebi li bontša hore lisele tsa T (mofuta oa sele e tšoeu ea mali) li phetha karolo ea bohlokoa tšenyo ea li-sheaths tsa myelin tse isang MS.
Antihistamines
Ba sebelisa boitsebiso ba ho laola lik'hamphani, bafuputsi ba UK ba ile ba hlahloba hore na li-antihistamine tsa ho robala le ho se behele li ne li amahanngoa le ntshetsopele ea MS. Lintho tse kang mafu a hlaselang (mohlala, asthma, eczema le furu fever) le ho tsuba li ile tsa fetoleloa. Bafuputsi ba fumane hore le hoja li-antihistamine tse sa sebetseng li ne li sa amane le kotsi ea MS, ho ba le li-antihistamine tse kileng tsa sebelisoa ke karolo ea 80 lekholong li fokotsa kotsi ea ho hlahisa MS.
Bafuputsi ba boletse hore lebaka leo ka lona ho robala antihistamine ka tsela e itseng ho ka ba le tšireletso ke hore-ho fapana le li-antihistamine tse se nang sedate-meriana ena e tšela thibelo ea mali le boko 'me e etsa liphello tse ling tse sa tšoaneng bokong le mokokong oa mokokotlo.
Mekhoa ea tlhekefetso ea molomo
Yong le basebetsi-'moho ba ile ba hlahloba lithuto tse hlano tse neng li batla ho kopana pakeng tsa tšebeliso ea lithibela-hloko tsa molomo le kotsi ea MS. Ka kakaretso, ho ne ho se na setsoalle pakeng tsa mefuta ena e 'meli.
More Info About Multiple Sclerosis
Multiple sclerosis e khetholloa ke timetso e khethollang ea myelin meleng ea methapo ea methapo ea methapo (boko ba mokokotlo le mokokotlo). Ha e ame lisele tsa methapo e fumanehang tsamaisong ea methapo ea methapo (ke hore, methapo le ganglia tse ka ntle ho boko le mokokotlo oa mokokotlo). Lefu lena le itšetlehile ka 'mele, e leng se bolelang hore' mele oa itlhaha.
Ntle le lithethefatsi tsa meriana, tse seng li sa tsoa tsejoa e le ntho e ka 'nang ea e-ba le etiologic, mabaka a mang a bakoang ke likokoana-hloko tsa MS li akarelletsa tse latelang:
- Nako ea ho pepeseha
- Ho tsuba
- Khatello ea kelello
- Matšoao a likokoana-hloko joaloka Epstein-Barr Virus
- Khatello ea kelello
- Letsatsi le fokotsehileng le fokotsehile
- Maemong a tlaase a vithamine D
Lefatšeng lohle, MS e ama batho ba limilione tse 2,5, 'me United States, batho ba fetang 400 000 ba na le lefu lena.
Ho qaleha ha MS ho ka 'na ha e-ba ka tšohanyetso kapa ka mohato o fokolang. Matšoao a pele a ka 'na a e-ba a patehileng hoo motho ea nang le MS a sa keng a ba hlokomela ka likhoeli kapa lilemo. Mona ke matšoao a mang a MS:
- Bofokoli
- Matšoao a utloahalang
- Litšitiso tse bonahalang
- Likhathatso tse nang le bothata le ts'ebelisano
- Ho potlakela ho kena metsing
- Kakaretso ea urinary
- Mokhathala
- Mathata a likoloi
Matšoao ana a ka pota-pota 'me a senya, ka litlhaselo tse tloaelehileng tse tšoarellang libeke kapa likhoeli li lateloa ke mokhoa o itseng oa ho hlaphoheloa. Matšoao a ka mpefala ka mocheso, mokhathala, boikoetliso kapa khatello ea kelello.
Qetellong, MS ke lefu la ho tlosoa, e leng se bolelang hore se fumanoa feela ka mor'a mafu a mang a kang a mokokotlo oa mokokotlo kapa lefu la encephalomyelitis (lehlakoreng la bobeli ho tšoaetso ea HIV). Ha ho hlahlojoa MS, histori le lipatlisiso tsa tlhahlobo ea 'mele hammoho le lithuto tsa MRI li thusa. Liphetoho ho li-biomarkers tsa cerebrospinal fluid li boetse li hlokometsoe.
Ka bomalimabe, ha ho pheko ea MS. Leha ho le joalo, ho na le phekolo e fumanehang, ho kopanyelletsa le corticosteroids le phapanyetsano ea mali ea phekolo bakeng sa phekolo ea maqhubu a matla, hammoho le mefuta e 'maloa ea phekolo ea mafu e kang beta-interferons bakeng sa ho thibela lisosa tse ncha tsa MS.
Lentsoe le Tsoang ho
Hopola hore tlhahlobo ena e hlophisitsoeng ea Yong le bangoli ba eona ke ba pele ho hlahloba tšusumetso ea lithethefatsi tse sa tšoaneng ho MS. Liphello tsa tlhahlobo ena e hlophisitsoeng li reretsoe ho fana ka leseling ka pathogenesis ea MS-boloetse boo re sa ntsaneng re bo utloisisa sesosa sa.
Nakong ena, ha ho na ngaka e tla sebelisa lithuto tsena ho tsamaisa phekolo. Boitsebiso leha e le bofe bo fumanoang tlhahlobisong ena e hlophisitsoeng bo hloka ho netefatsoa le ho phetoa. Haeba u noa meriana leha e le efe 'me u tšoenyehile ka hore na e ama tšoaetso ea MS joang, ikutloe u lokolohile ho buisana ka seo u se ithutileng ka ngaka ea hao e bolelang. Leha ho le joalo, u se ke ua khaotsa (kapa qala ho noa) meriana ho latela seo u se balang sehloohong sena-le ntle le kopo ho ngaka ea hau.
> Mehloli:
> Multiple Sclerosis. Ka: Kasper DL, Fauci AS, Hauser SL, Longo DL, Jameson J, Loscalzo J. eds. Manual ea Medicine ea Harrison, 19e New York, NY: McGraw-Hill.
> Multiple Sclerosis. MedlinePlus.
> TNF Inhibitors. Koleji ea Amerika ea Rheumatology.
> Yong HY et al. Ho pepeseha lithethefatsi le kotsi ea multiple sclerosis: Tlhahlobo e hlophisitsoeng. Pharmacoepidemiol Drug Safsa. 2017; 1-7.