Karolo ea Li-Cannabinoids ho Kankere ea Kankere
Cannabis sativa , eo hangata e tsejoang e le semela sa matekoane, e na le histori e telele ea bongaka. Ha e le hantle, ho na le bopaki bo ngotsoeng mabapi le tšebeliso ea bongaka ea kankere e nyenyane ea Chaena e kopanelang lilemong tse fetang 5 000 tse fetileng. E ne e kgothaletswa bakeng sa maloetse a fapaneng ho tloha ho letšollo le ho ba le mongobo ho tswa ho ho nyekeloa ke pelo le sefubeng sa sefuba, hape o sebelisoa e le ho hlakola ha bohloko, ho hlaphoheloa ke bohloko le ho theola maikutlo.
Ha tsebo ea rona ea 'mele oa motho le mafu a ntse a hōla, le kutloisiso ea rona ea meriana ena ea boholo-holo. Ke kankere efe e phethang karolo ea phekolo ea lefu la kankere ea kajeno kapa lefu la lymphoma?
Li-Cannabinoids ke Eng?
Semela sa Cannabis sativa se hlahisa lik'hemik'hale tse fetang 70 tse tsejoang e le li-cannabinoids. Le hoja hoo e ka bang tse 60 tsa tsena tse kang li-cannabinoids li sa sebetse 'me li na le phello e fokolang kapa e se nang letho mosebetsing oa boko ba rona, metsoako e setseng e ka ba matla haholo' me e ka sebelisoa meriana ho tšoara matšoao a mangata.
Ntho e kholo ka ho fetisisa ea li-cannabinoids tsena ke tetrahydrocannabinol (THC) , e sebetsang ka matekoane. Ho fumanoa ha THC lilemong tsa bo-1970 ho lebisa tlhokomelo ea meriana, dronabinol (Marinol), nabilone (Cesamet), Sativex, Levonantradol le Synhexyl tse thehiloeng mefuteng ea tlhaho ea tlhaho ea tlhaho ea THC.
Cannabinoids e Sebetsa Joang?
Lingaka li ne li hlahisa li-cannabinoids pele li tseba hantle hore na li sebetsa joang.
Ho tloha ka nako eo, bafuputsi ba fumane li-receptor tse peli 'meleng ea rona moo liketso tsa cannabinoids li sebetsang. Li bitsoa receptor 1 ea cannabinoid (CB1) le receptor 2 ea kannabinoid (CB2).
CB1 ke mokelikeli o teng haholo-holo tsamaisong ea rona ea methapo e tlatsetsang ho senya, ho hlatsa le ho tšoenyeha, 'me ke eona e amehang ke kannete le THC.
CB2 e fumanoa lithong tse ling tsa 'mele' me e phetha karolo ea bohlokoa tsamaisong ea 'mele ea rona ea ho itšireletsa mafung .
Li-cannabinoids li susumelletsa li-receptor tsena, tse qetellang li lebisa ho phomolo ea matšoao.
Ke Eng e ka Etsoang ke Kannete?
Hona joale, li-cannabinoids li lumelloa hore li sebelisoe ke bakuli ba kankere ba nang le ho nyekeloa ke pelo le ho hlatsa e sa kang ea arabela kalafo ea tloaelehileng , hammoho le ho susumetsa takatso ho bakuli ba nang le AIDS / HIV. Leha ho le joalo, lithuto tsa meriana li bontšitse hore phekolo ea kankere ea kankere e ka atleha ho laola matšoao a mangata a mokuli oa kankere:
- Ho tepella maikutlong
- Ho tšoenyeha
- Bohloko
- Ho lahleheloa ke 'mele
- Ho robala hampe
Ho phaella moo, liphuputso li ntse li tsoela pele ho fumana hore na meriana e amang metsoako ea CB2 (tšoaetso ea mafu a mangata) e ka bolaea lisele tsa kankere.
Ke habohlokoa ho hlokomela hore phekolo ea kankere ea mofuta ona ha e sebetse bakeng sa motho e mong le e mong, le hore ka linako tse ling litla-morao tse mpe li phahametse molemo oa lithethefatsi. Haeba u e-na le ho nyekeloa ke pelo le ho hlatsa e ke keng ea laoloa, kapa u nahana hore u ka rua molemo kalafo ea kankere, bua le ngaka ea hau ea bophelo.
Ke Lintho Life Tse ka Lebelloang?
Joaloka meriana leha e le efe, li-cannabinoids li ka baka litla-morao tse 'maloa:
- Ho otsela
- Pherekano
- Khaello ea mali
- Molomo o omileng
Bakuli ba bang ba nkang dronabinol ba ka 'na ba ba le "phahameng" e tšoanang le maikutlo a tsamaeang le matekoane.
Litla-morao tse mpe tsa li-cannabinoids hangata li amana le tekanyo e phahameng 'me e ka fokotseha ha u ntse u tsoela pele ho e nka.
Li-Cannabinoids li Nkoa Joang?
Boholo ba li-cannabinoids li nkoa ka lipilisi kapa foromo ea capsule. Ketso ea meriana ena e ka 'na ea ipha nako ea ho fana ka phomolo, kahoo haeba u noa meriana ena bakeng sa khatello ea kelello kapa lithethefatsi, u tla batla ho lula lenaneong le tloaelehileng mme u se ke ua emela hore matšoao a hao a tsoe pele a nka e.
Sativex, e leng motsoako oa 50/50 oa THC hammoho le mofuta o mong oa kannete o bitsoang cannabidiol, ke metsi a tšeloang molomong oa hao kapa ka hare ho lerama la hao.
Ho qala ha ketso ea Sativex ho potlakile ho feta mefuta e meng ea li-cannabinoids.
Ho thoe'ng ka Marijuana?
Ha meriana ea lithethefatsi e hlahisoa ka laborateng, e etsoa ho finyella tataiso e thata haholo ea machaba ea taolo. Litlhoko tsena li thusa ho netefatsa hore sehlahisoa sa ho qetela se sireletsehile ebile sea sebetsa. Ho itšetlehile ka hore na limela tsa li-cannabis li hōlile joang, mme matekoane a ka fapana hakae ho tloha betheng ho ea ho e le 'ngoe' me a se ke a latela tataiso leha e le efe ea polokeho. Ho phaella mathateng afe kapa afe ao a ka a hlahisang le hore na sehlahisoa se sebetsa hantle hakae, ho ka 'na ha e-ba le litšila tse ngata tse teng tse ka lebisang litla-morao tse mpe kapa tšoaetso haeba e kenoa.
Ntle le ho se lumelloe ke molao libakeng tse ngata, ho tsuba ha matekoane ho ka boela ha lebisa ho halefa ha matšoafo, 'me, ho ea ka lipatlisiso tse ling, ho ka baka moferefere .
Ho e qaqisa
Le hoja matekoane a meriana a tumme mecheng ea liphatlalatso lilemong tse 'maloa tse fetileng, cannabis sativa e' nile ea sebelisoa ho hlokomela mokuli ka lilemo tse likete. Ha re ntse re ithuta ho eketsehileng ka melemo ea tse ling tsa metsoako e nang le kankere, bo-rasaense ba loanela ho arola le ho hloekisa lik'hemik'hale tsena bakeng sa tšebeliso e sireletsehileng.
Lisebelisoa
Guy, G., Stott, C. "Tsoelo-pele ea Sativex- meriana ea tlhaho ea lithethefatsi" Mechoulam, R. (ed) (2005) Cannabinoids e le Therapeutics Birkhauser Verlag: Basel, Switzerland. (maq. 231- 263).
Hanus, L., Mechoulam, R. "Khemistri ea Cannabinoid: tlhahiso-pono" ho Mechoulam, R. (ed) (2005) Cannabinoids e le Therapeutics Birkhauser Verlag: Basel, Switzerland (maq. 23- 46).
"Mustnabinoids le Matšoenyeho" a Mechoulam, R. (ed) (2005) Cannabinoids e le Therapeutics Birkhauser Verlag: Basel, Switzerland. (maq. 141- 147).
Petrocellis, L., Bromcoco, M., Ligresti, A., Di Marzo, V. "Ho sebelisoa ha cannabimimetics ha ho phekoloa kankere" Mechoulam, R. (ed) (2005) Cannabinoids e le Therapeutics Birkhauser Verlag: Basel, Switzerland. (maq. 165- 181).