Jero ea litholoana tsa morara e tsejoa hore e sebelisane le meriana e 'maloa , e eketsa phello ea eona hangata maemong a chefo. Kahoo, ha ho tluoa tabeng ea Plavix (clopidogrel), meriana e matlafatsang ea mali e sebelisetsoang ho fokotsa ho ata ha lefu la likokoana-hloko le likokoana-hloko, na ho sireletsehile ho ja lero la tholoana? Karabo e khutšoanyane ke "che."
Na lero la morara oa morara le kopana joang le Plavix?
Phuputso ea 2014 e fumane lero la litholoana tsa morara e thibela bobeli ba enzyme ea CYP3A4, eo clopidogrel e leng substrate, le enzyme ea CYPC19, e hlahisang meriana.
Ka hona, lero la litholoana tsa morara le ka kena-kenana le phetoho ea clopidogrel le sebōpeho sa eona se mafolofolo, kahoo ho fokotsa moriana oa antiplatelet e le oa bohlokoa ho thibela lefu la pelo kapa lefu la pelo.
'Meleng, clopidogrel e sebelisoa ka metsoli e sebelisa enzyme ea CYP2C19. Leha ho le joalo, batho ba itseng ke mafokolisi a futsanehileng a enzyme ea CYP2C19. Batho bana ba hanyetsa ho clopidogrel. Le hoja ho na le teko ea mali ho tseba bakuli ba hanyetsang clopidogrel pele setsi sa phekolo se nang le meriana, tlhahlobo ena ha e sebelisoe haholo. Tlhokomeliso, batho ba futsanehileng, ba na le kotsing e kholo ea ho shoa ha liketsahalo tsa pelo kapa methapo ea mafu.
Ho ea ka tlaleho ea FDA, meriana e meng ea pelo eo lero la morara e sebetsang le eona e akarelletsa:
- li-statins (tse kang Zocor le Lipitor)
- meriana ea khatello ea mali joaloka nifedipine
- meriana ea anti-arrhythmia e kang amiodarone
Ntle le meriana ea pelo, lero la morara o boetse o ama lithethefatsi tse latelang:
- meriana e sebelisetsoang ho kenyelletsa litho joaloka cyclosporine
- meriana e thibelang ho tšoenyeha joaloka buspirone
- antihistamines joaloka Allegra
Jero ea litholoana tsa morara e ka ba karolo ea bophelo bo botle. Haeba u e-na le meriana ea pelo, ka kōpo buisana hore na ke maikutlo a monate ho noa lero la morara le mooki oa hau kapa mofani e mong oa tlhokomelo ea bophelo.
Etsa bonnete ba hore o tsebisa mofani oa hao oa tlhokomelo ea bophelo meriana eohle eo ue noang le litekanyetso tsa meriana ena.
Lentsoe le Tsoang ho
Kamehla ho na le maikutlo a matle ho bala ka hloko papatso e hatisitsoeng e nang le clopidogrel. Ho lokela ho ba le karolo mabapi le ho sebelisana pakeng tsa clopidogrel le meriana e meng. Haeba o ne o sa fumane sephutheloana se kenyelletsweng, botsa setsebi sa hau sa meriana bakeng sa kopi.
Haeba u sebelisa meriana leha e le efe ea over-the-counter (OTC) kapa li-supplementary diet, u lokela ho bua le setsebi sa hau sa meriana le ngaka ka ho sebelisana ho ka etsahala. U lokela ho ba hlokolosi haholo ka ho sebelisa meriana ea ho ruruha joaloka ibuprofen le OTC e tlatsitseng e nang le ginkgo. Tšusumetso e mpe ea lihlahisoa tsena e tsoa mali.
> Mehloli:
> Holmberg MT, Tornio A, Neuvonen M, Neuvonen PJ, Backman JT, Niemi M. Meroho ea litholoana e thibela ho sebelisoa ha methapo ea clopidogrel. Clin Pharmacol Ther . 2014 le: 10.1038 / clpt.2013.192
> Krasowski MD. Pharmacogenomics. Ka: South-Paul JE, Matheny SC, Lewis EL. eds. Tlhaloso ea CURRENT & Phekolo: Family Medicine, 4e . New York, NY: Hill ea McGraw; 2015.
> Trevor AJ, Katzung BG, Kruidering-Hall M. Pharmacogenomics. Ka: Trevor AJ, Katzung BG, Kruidering-Hall M. eds. Katzung & Trevor's Pharmacology: Ho hlahlojoa le ho hlahloba boto, 11e . New York, NY: Hill ea McGraw; 2015.