Na nicotine e bakisa kankere kapa e etsa hore kankere e jale? Nicotine e na le phello efe litabeng tsa kankere? Ha ho ntse ho eketseha ho tlohela ho tsuba lithuso tse nang le nicotine ho ba teng, tsena ke lipotso tse bohlokoa haholo. Ka lehlakoreng le leng ho bua leshano phaello ea phekolo ea phekolo ea pheko ea nicotine-e ka thusa batho ho khaola mokhoa o tsejoang hore o baka kankere (le mafu a mang a mangata). Ka lehlakoreng le leng ke batho ba bontšang hore nicotine e ka bolaea ebile e sebelisoa pele e le likokoana-hloko.
Phello ea Nicotine Kankere
Ho arabela potso ena-karolo ea nicotine mabapi le kankere-potso e tlameha ho rojoa ka lihlooho tse 'maloa. Ka hona, re lokela ho hlahloba karolo ea nicotine ho latelang:
- Ho ntša mokokotlo Qalong kapa Mutagenicity - Sena se bolela bokhoni ba ntho e bakang tšenyo (liphetoho tsa lefutso ka DNA) ho hlokahala hore ho fetole sele e tloaelehileng hore e be seleng ea kankere .
- Tsoelo-pele ea boipelaetso / Khōlo ea ho senya - Sena se bolela bokhoni ba ntho e etsang hore hlahala e se e ntse e le teng ho hōla ka potlako le / kapa ho hasana (metastasize) libakeng tse ling tsa 'mele ka potlako.
- Phello ea Phekolo ea Kankere - Sena se bolela phello eo ntho e ka 'nang ea e-ba le eona ka phekolo ea kankere, mohlala, haeba ntho e thibela kapa e thibela liketso tsa chemotherapy.
Karolo ea Ntoa ea Nicotine e Bapala Kankere
Le hoja liphuputso li sa etsoa ka liphello tsohle tse ka khonehang tsa nicotine liphatseng tsohle tsa kankere. Hape, lithuto tse ngata ho fihlela joale li entsoe ka litoeba, likhoto, kapa lisele tsa kankere tse hōlileng ka laborateng, re tseba tse latelang:
- Phello ea Nicotine ka Tlhaho Qalong kapa Thuto ea Mantlha - Liphuputso tsa morao-rao li bontšitse hore nicotine e na le liketso tsa mutagenic le tse khothalletsang tumor. Hape ho na le bopaki ba hore bokoali bo ka baka tšenyo ea DNA-mofuta oa tšenyo e ka lebisang kankere. Hape ho boetse ho na le bopaki ba hore bokoali bo hlahisa mokhoa oa carcinogenesis-e bolelang hore ts'ebetso ea sele e fetoha kankere ho arabela ntho e 'ngoe e ntlafatsoa. Sena ha se bolele hore ha se kotsi ho ba se nang kankere. Liphello tse ka tlase li ka etsahala ha kankere e teng empa e e-s'o fumanoe.
- Phello ea ho Ntšetsa Pele Mahlapa le Khatelo-pele - Le hoja bokoali bo ka 'na ba se ke ba ikarabella bakeng sa lisele tsa pele tse hlahisang kankere hore e be kankere, liphuputso tse ling tse eketsehileng li bontšitse hore ha kankere e itseng e ntse e tsoela pele, nicotine e ka kgothaletsa kholo ea hlahala. Ho etsa mohlala, nicotine e fumanoe ho khothalletsa ts'oaetso ea kankere ea pancreatic ho litoeba. E boetse e fumanoe ho khothalletsa ho ata, ho hlaseloa, le ho falla ha lisele tse nang le kankere e seng e nyenyane ea kankere ea matšoafo.
- Phello ea Likarabo ho Kalafo ea Kankere - Ho fumanoa hore Nicotine e kena-kenana le tse ling tsa phekolo ea kankere, e leng se ka 'nang sa bolela hore nicotine e ka fokotsa litekanyetso tsa ho pholoha ka kankere. Ka mohlala, nicotine e ka khothalletsa ho hanyetsa Platinol ea lithethefatsi (cisplatin) lisele tsa kankere ea matšoafo.
Ke habohlokoa ho hlokomela hore, boholo ba lithuto tsena, nicotine e hlahlojoa e arohane le ho tsuba koae e le ho etsa bonnete ba hore liphello li bakoa ke nikotine feela ho e-na le lintho tse ling tse teng ka koae.
Kamoo Nicotine e Sebetsang Kateng ho Ntšetsa Pele Khōlo ea Kankere le ho Hasana le ho Fokotsa Katleho ea Phekolo
Ho na le litsela tse fapa-fapaneng tseo nicotine e fumanehang ho tsona ho ama kgolo le ho ata ha kankere.
Tsena li kenyelletsa:
- Ho ntlafatsa ts'ebetso ea kankere (joalokaha ho boletsoe ka holimo).
- Ho khothaletsa ho ba le malinyane (ka liprotheine tse susumelletsang ho arohana ha sele le ho hōla).
- Ho hlohlelletsa ho ata ha kankere (mohlala, ka ho ntlafatsa motility ea lisele tsa kankere (joalokaha ho boletsoe ka tlase).
- Ho ntlafatsa li-angiogenesis - Nicotine e ka ntlafatsa bokhoni ba kankere ho hlahisa methapo e mecha ea mali e hlokahalang bakeng sa ho hōla le ho thibela lefu la tlhaho la lisele tse tsofetseng kapa tse sa tloaelehang (apoptosis.)
- E bakang ts'oaetso ea chemoressa - Ka tsela e susumetsang litsela tse sa tšoaneng, nicotine e ka 'na ea etsa hore hlahala e se ke ea hlola e e-na le bothata ba chemotherapy.
Le hoja ho hlalosa mekhoa e tobileng ho na le lisebelisuoa tse matla le ho feta moo sehlooho sena se leng teng, mehlala e seng mekae eo nicotine e fumanoeng ho e khothalletsa ho hōla le ho ata ha kankere e kenyelletsa:
- Khootine e ka sebetsa ka ho tlama ka li-receptors tse bitsoang nicotinic acetylcholine receptors (nAChRs). Ha e le hantle, ena ke tsela eo nicotine e lemalang ka eona. Ka ho etsa li-receptor tsena, nicotine e ka eketsa kholo ea lihlahala, ho etsa hore ho be le methapo e mecha ea mali e hlokahalang hore kankere e hōle ( angiogenesis ) le ho thibela lefu (apoptosis) ea lisele tsa kankere. Kaha ho na le mefuta e fapaneng ea li-aciclinoline receptors har'a batho ba fapaneng, liphello tsena li ka boela tsa fapana har'a batho ba fapaneng. (Ho thahasellisang ke hore ho lemalla ha nicotine ho matla ho amana le kotsi e kholo ea kankere ea matšoafo.)
- Nicotine e susumelletsa protheine e tsejoang e le beta-arrestin-1. Protheine ena e boetse e eketsa ho tsamaisoa ha lisele tse itseng tsa kankere ea matšoafo ho li nolofalletsa ho hasa le ho hlaseloa habonolo.
Cancer e Amana le Nicotine ka Tsela e 'Ngoe
Phello ea nikotine ha ho qaleha, ho hatela pele le ho arabela kalafo ha e e-s'o ithutiloe bakeng sa kankere eohle, empa ho na le bopaki ba hore bokoali bo ka 'na ba e-ba le karolo e kotsi bonyane tsela e le' ngoe bakeng sa lik'hamphani tse latelang:
- Kankere e nyenyane ea lefu la sapole
- Kankere e seng e nyane ea kankere ea matšoafo
- Litho tsa kankere tsa hlooho le molala
- Kankere ea gastric (kankere ea mala)
- Kankere ea Pancreatic
- Kankere ea Gallbladder
- Kankere ea sebete
- Kankere ea Colon
- Kankere ea matsoele
- Lefu la mokokotlo
- Kankere ea kankere
- Lefu la liphio (kankere ea masapo a renal)
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