Hoo e ka bang lilemong tsa bo-1940, bo-rasaense ba ne ba hlokometse hore baahi ba nang le ts'oaetso ea letsatsi haholo ba na le kankere e phahameng ea kankere ea letlalo, empa ho na le litekanyo tse fokolang tsa kankere e meng. Ho theosa le lilemo, liphuputso li fumane likarolo tse fapaneng tsa lik'hemik'hale ho likhaolo tsa lik'hemik'hale tse fapaneng tse 24 tse nang le likarolo tse tlase tsa kankere libakeng tse nang le ts'ebetso ea letsatsi.
Kajeno, ho hlakile hore vithamine D ke eona e ikarabellang bakeng sa mefuta ena, 'me re na le bopaki bo matla ba hore ho boloka litekanyo tse lekaneng tsa vithamine D ho thusa ho thibela kankere e mengata ea kankere ea kankere e kenyeletsang, hammoho le lefu la pelo, methapo ea boipheliso, le ea osteoporosis.
The Link Between Vitamin D le Kankere ea Letlalo
Har'a basali ba tšoeroeng ke kankere ea matsoele , karolo ea 75 lekholong ha e na matla a vithamine D. Basali ba nang le litekanyo tse lekaneng tsa vithamine ea mali ha ba khone ho fumanoa ba e-na le kankere ea matsoele, 'me ba seng ba e-na le kankere ea matsoele ha ba khone ho fumana lefu lena hape haeba maemong a bona a vithamine D a lekane. Ka 2014, tlhahlobo ea litlhahlobo tsa liteko tse 56 e ile ea etsa qeto ea hore vithamine D3 supplementation e amahanngoa le ho fokotseha ha karolo ea 12 lekholong ea kotsi ea lefu ho tsoa ho kankere leha e le efe.
Vithamine D e na le tšusumetso e khethehileng khahlanong le kankere ea matsoele. Monyetla ona o ile oa tsosoa ha thuto ea basali ba fetang 57 000 ba emang ka morao-rao e fumanoa hore basali ba nkiloeng ke vitamin D ba tlatsetsa ka liphesente tse 26 kotsing ea kankere ea matsoele. Se entseng hore sena se fumanoe ka ho khetheha ke hore se etsahetse ka ho khetheha ho basali ba neng ba boetse ba sebelisitse phekolo ea phetoho ea li-hormone .
Tšebeliso ea phekolo ea phetoho ea li-hormone ho basali ba postmenopausal e ile ea theoha ka matla ka mor'a 2002, ha thuto e kholo, e bitsoang Women's Health Initiative, e emisoa pele ka lebaka la keketseho ea lefu la pelo, leqeba le kankere ea matsoele sehlopha se amohelang phekolo ea hormone.
Estrogen e tsejoa ho susumetsa kholo le ho ata ha lisele tsa kankere ea matsoele.
Ho pepeseha ha sethoathoa ke estrogen, ka lebaka la lintho tse kang ho qala khoeli le ho feta mafura a 'mele , li amahanngoa le kotsi e kholo ea kankere ea matsoele. Ho ka 'na ha e-ba le liphello tse ngata tsa li-vithamine D tse khahlanong le liphello tsa kankere.
Lintho tse ling tsa lijo tse hanyetsang liketso kapa tlhahiso ea estrogen li amahanngoa le kotsing e fokotsehileng ea kankere ea matsoele. Mehlala e 'maloa: li-mushroom li na le aromatase inhibitors (aromatase ke enzyme e hlahisang estrogen); li-soya le folaxe le lipeo tsa chia li na le li-phytoestrogens tse nang le liphello tse khahlanong le estrogen; ho ja lijo tse ngata ho etsa hore ho be le sehlabelo sa estrogen. Ho bonahala eka vithamine D e na le liphello tse tšoanang.
Ho ea ka lipatlisiso tsa vitro tsa lisele tsa kankere ea matsoele, mofuta o sebetsang oa vithamine D o senya polelo ea aromatase, e hlahisang tlhahiso e tlase ea estrogen. Ho boetse ho bontšitsoe hore vithamine D e fokotsa palo ea li-receptor tse entsoeng ka kankere ea matsoele, tse etsang hore lisele li se ke tsa arabela liphatlalatsong tsa kankere tsa tlhahiso ea kankere.
Na Letsatsi le Lekaneng?
Vithamine D e hlahang letlalong e fapana pakeng tsa batho. Ha ho na nako e tobileng ea letsatsi le leng le le leng la ho pepeseha ha letsatsi le tla sebetsa bakeng sa bohle, 'me ho ba bangata ba rona, ho ba le letsatsi le lekaneng la ho pepa ha letsatsi ho ke ke ha lekaneng.
Phuputsong ea baahi ba Hawaii ba nang le khanya e khanyang ea letsatsi-ka karolelano lihora tse 29 ka beke-likarolo tse 50 li ntse li e-na le vithamine D tse ka tlase ho 30 ng / ml. Ho feta moo, ba bang ba rona re phela literekeng tse phahameng tse etsang hore vithamine D e lekaneng.
Tsela e molemo ka ho fetisisa ea ho tseba hantle ke ho ba le teko ea 25 (OH) D ea mali. Re khothaletsa ho sebelisa lisebelisoa tse ling ho fihla sebakeng se monate sa 30-45 ng / ml. Bakeng sa batho ba bangata, tekanyo ea letsatsi le letsatsi ea vithamine D3 (hoo e ka bang 1000-2000 IU / letsatsi) e loketse ho fihlella fensetere ea 30-45 ng / ml.
> Mehloli:
> Grant WB. Liphuputso tsa tikoloho ea UVB-vitamin D-kankere ea maikutlo. Anticancer Res 2012, 32: 223-236.
> Krishnan AV, Swami S, Feldman D. Melemo ea phekolo ea vithamine D ea ho phekola kankere ea matsoele. Steroids 2012, 77: 1107-1112.
> Cadeau C, Fournier A, Mesrine S, et al. Tšebelisano pakeng tsa vitamine D ea tlatsetso le phekolo ea meriana ea menopausal e sebelisoang kotsing ea kankere ea matsoele: bopaki bo tsoang ho sehlopha sa E3N. Am J Lithethefatsi tsa Meriana ea 2015, 102: 966-973.
> Binkley N, Novotny R, Krueger D, et al. Boemo ba vithamine D bo fokolang ho sa tsotellehe tlhahiso ea letsatsi e ngata. J Clin Endocrinol Metab 2007, 92: 2130-2135.
> Bischoff-Ferrari HA. Optimal serum 25-hydroxyvitamin D maemo a liphello tse ngata tsa bophelo bo botle. Adv Exp Med Biol 2008, 624: 55-71.