Ho hakanngoa hore Maamerika a limilione tse 33 a phela ka makhetlo a feteletseng kapa a "leaky": boemo bo sa phutholohang le bo ka 'nang ba hlajoa ke lihlong bo thata ho bo tšoara. Ka lilemo tse fetang mashome a mararo, ha ho na meriana e mecha ea ho phekola boemo bona. Leha ho le joalo, ka 2012, FDA e ile ea amohela Myrbetriq (mirabegron) ho phekola senya.
Khokho ea khomo e feteletseng kapa ho khothalletsa ho itlosa bolutu ho bolela ho se sebetse ha mesifa ea detrusor.
Moriana oa detrusor ke karolo ea lerako la senya, 'me ha e fetile, e etsa likonteraka tse ngata haholo, mme ho na le ho tsoa ha motlakase.
Sekhohlaretsi se matlafatsang ke mokhoa o tloaelehileng ka ho fetisisa oa ho ntša metsi monoaneng. Basali ba nang le boemo bona ba ikutloa ba le takatso e matla ea ho ntša metsi ka mor'a hore ho na le litšila tse sa laoleheng. Banna ba na le matšoao a tšoanang, empa ho fokola ho ka senyeha ke benign prostatic hypertrophy kapa tšitiso ea ho itšireletsa.
Khetho ea Meriana e fetileng
Pele Myrbetriq e kenyelletswa, senya e feteletseng e ne e tšoaroa ka ho ikoetlisa ka tlaase (Kegel) le biofeedback; mokhoa oa ho fetola mokhoa oa ho phela, o kang boima ba 'mele kapa ho qoba ho ba le caffeine; onabotulinumtoxinA kapa ente ea Botox ka har'a mesifa ea mokokotlo; le li-antimuscarinic tse kang Detrol (tolterodine), Urotrol (oxybutynin) le solifenacin.
Lithethefatsi tsa Antimuscarin li na le liphello tse ngata tse mpe tse etsang hore li se ke tsa imeloa ke batho ba bangata ba li nkang. Liphello tsena tse bohloko li kenyelletsa molomo o omeletseng, ho patoa, pono e hlakileng le ho tsieleha ha tsebo.
(Hangata toxidrome e amahanngoa le polelo e reng, "Le foufetse joaloka batlatsi, le hlanya joaloka lehloeo, le khubelu joaloka beet, le chesa joaloka Hadese, le omme joaloka lesapo, lesapo le senya li lahlile molumo oa tsona, 'me pelo e matha e le mong." )
Melemo ea Myrbetriq
Myrbetriq e totobetse haholo liketsong tsa eona ho feta lithethefatsi tsa antimuscarinic tseo hangata li sebelisetsoang ho phekola senya.
Myrbetriq le eona ha e hanyetse tsamaiso ea methapo e nang le kutloelo-bohloko e feteletseng joaloka lithethefatsi tsa antimuscarin. Ka ho khetheha, mirabegron ke beta - 3 adrenergic agonist e hlaselang ka ho khetheha li-receptors ka mesifa ea mokokotlo (karolo ea 97 lekholong ea beta -3 mRNA e hlahisoang ke 'mele e hlahisoa ke mesifa ea mokokotlo).
Ho fapana le lithethefatsi tsa antimuscarinic, mirabegron ha e sitise beta-1 le beta-2 receptors likarolong tse ling tsa 'mele. Ka mantsoe a mang, ha lithethefatsi tsa antimuscarinic li na le morero o futsanehileng 'me li ama mekhoa e fapaneng ea likarolo, mirabegron e nepahetse ebile e ama haholo senya.
Tlhahlobo ea Meriana ea Meriana le Liphello Tse Ntle
Nakong ea liteko tsa meriana ea Phase II le ea Phase III, Myrbetriq e ile ea lekoa ho barupeluoa ba fetang 10 500. Lipatlisisong tsena, barupeluoa ba bontšitse ho fokotseha ha motsoako oa motsoako, palo ea matšoao a potlakileng, likarolo tse ngata tsa incontinence le palo ea liketsahalo tsa nocturia (boits'oaro bosiu)
Le hoja Myrbetriq e ipakile e mamelloa haholo ho feta lithethefatsi tsa antimuscarinic, nakong ea liteko tsa meriana, batho ba bang ba ntse ba e-na le liphello tse bohloko tse kenyeletsang:
- khatello ea mali e eketsehileng
- tšoaetso ea urinary
- bohloko ba mpeng
- tekanyo ea pelo e phahameng
- khatello ea mali e phahameng
- matšoao a pholileng
Le hoja ho eketseha ha pelo le khatello ea mali e sebelisoang ke Myrbetriq ke boikokobetso, litsebi tse ling li tšoenyeha ka liphello tsa pelo tsa Myrbetriq.
Haholo-holo ho ea ka nako, ho 'nile ha e-ba le lipatlisiso tse nyenyane mabapi le tšebeliso ea Myrbetriq ho batho ba baholo ba baholo ho feta lilemo tse 70; ka hona, lingaka tse ling ha li fane ka meriana ena ho bakuli ba hōlileng ba nang le mathata a pelo le a liphio. Ho feta moo, ha ho sa utloisise hore na Myrbetriq e sebetsa ha e sebelisoa le lithethefatsi tsa antimuscarinic.
Ka August 2015, FDA e fana ka tataiso e hlahisoang ke liphihlelo tsa postmarketing le Myrbetriq. Ka mor'a hore lithethefatsi li lokolloe sechabeng, batho ba bang ba ile ba e-ba le tse latelang:
- ho nyekeloa ke pelo
- angioedema (ho ruruha) ea sefahleho, leleme kapa larynx
- ho itchiness (pruritis)
Liketsahalo tsa bobeli ba angioedema ho sebelisoa ha Myrbetriq li ka beha bophelo kotsing haeba tsela e ka holimo ea moea e koetsoe.
Haeba u e-na le li-angioedema kapa tse ling tse amanang le matšoao ka mor'a hore u noe meriana ena, hang-hang u bitse litšebeletso tsa tšohanyetso kapa u batle lingaka tse ka u thusang.
Ntle le ho mamelleha ho feta lithethefatsi tsa antimuscarinic litsing tsa meriana, Myrbetriq e boetse e paka hore ho ntlafatsa boleng ba mekhoa ea bophelo har'a batho ba nang le senya e feteletseng. Ka kakaretso, Myrbetriq e bonahala e le mokhoa o mocha oa ho phekola kankere e feteletseng haholo-holo har'a batho ba ke keng ba mamella lithethefatsi tsa antimuscarin. Leha ho le joalo, lipatlisiso tse ngata li lokela ho etsoa pele re utloisisa hantle hore na ke mekhoa efe ea phekolo le Myrbetriq.
Lisebelisoa:
Chapple, CR. Mirabegron ka Sekhahla se Feteletseng: Tlhahlobo ea Efficacy, Tšireletseho, le ho mamella. Neurourology le Urodynamics. 2013.
Harper G, Johnston C, Landefeld C. Geriatric Disorders. Ka: Papadakis MA, McPhee SJ, Rabow MW. eds. Tlhahlobo ea Bongaka ea Meriana le Kalafo ea 2015 . New York, NY: Hill ea McGraw; 2014.
Khullar V et al. Liphello-Liphello Tse Tlalehileng Le Mirabegron ea b3-Adrenoceptor Agonist Phatlalatsong ea Bobeli ea Palo ea bakuli ba nang le senya se fetang. Neurourology le Urodynamics. 2015.
> Myrbetriq (mirabegron) Lipampiri tse eketsehileng. www.fda.gov.