Bohloko ba litho tsa ka hare le IBS
Haeba o e-na le hypersensitivity ea visceral, ho bolela hore o theohile ka tlaase ho bohloko ba mpeng le ka bothata ha u arabela khatello, ho tsosolosa kapa ho senyeha ka mpeng. Ho ba le hypersensitivity (visceral hyperalgesia) ke lentsoe le sebelisetsoang ho hlalosa phihlelo ea bohloko har'a litho tsa ka hare (viscera) ka tekanyo e matla ho feta e tloaelehileng.
Matšoao a tšoaetsanoang a maiketsetso ke tšobotsi e hlaheletseng ea lefu la sefuba (IBS). Leha ho le joalo, ho ba le hypersensitivity e hlahelletseng ho ka boela ha e-ba teng ho batho ba nang le:
- Mahlaba a se nang lefu la pelo
- Ho sebetsa dyspepsia
- Mahlaba a ka mpeng a sebetsang
Ho lekanya Hypersensitivity Visceral
Bafuputsi ba hlahloba hypcerensitivity ea visceral ho leka ho utloisisa hore na ke hobane'ng ha batho ba e-na le IBS. Bakeng sa merero ea ho etsa lipatlisiso, tlhahlobo ea hypersensitivity ea visceral e atisa ho lekanyetsoa ho sebelisa teko ea ho khetholla balloon. Sena se leka karabo ea mokuli ho hatelloa ka hare ho eona.
Ka tsela ea balloon distension, balloon ka rectum le butle-butle tlala moea. Batho ba khetholloa ka ho ba le hypcerensitivity ea visceral ha ba tlaleha bohloko ka maemong a tlase a khatello ho feta ba bang ba khonang ho mamella phallo e kholo ea moea ntle le tlaleho e sa thabiseng. Liphuputsong tse joalo tsa lipatlisiso, batho ba nang le IBS ba atisa ho ba le bothata bo tlase ba bohloko.
Hypersensitivity ea ho shebahala le IBS
Le hoja hypcerensitivity ea visceral e nkoa e le ea bohlokoa ho IBS, hoo e ka bang karolo ea 30 lekholong ho ea ho karolo ea 40 lekholong ea batho ba nang le IBS ba fumanoe ba na le kutloisiso e feteletseng ea ho khetholla ka har'a kolone. Hape, ka thahasellisang, ho hang ha ho na kamano e tobileng pakeng tsa tlhahiso ena e matlafatsang le boima ba matšoao a IBS a motho.
Ho bonahala eka lefu la hypcerensitivity ea visceral le bonoang ho bakuli ba bang ba IBS ka lebaka la liphetoho tsamaisong ea methapo e sebetsang boemong ba mala le boko. Mekhoa ea methapo ea matšoao ea moriana e matlafatsoa ke ho tsosolosa, e leng se etsang hore ho be le matla a ho khutlisetsa matla 'meleng le ho tlisa bohloko bo matlafatsang. Batho ka bomong ba se nang IBS, rectal distension ho baka karabo likarolong tse ling tsa boko tse amanang le bohloko bo tsamaisang bohloko. Bakeng sa bakuli ba IBS, ts'ebetso ena e ts'oarang maikutlo e etsa hore likarolo tsa boko li amanang le ho falimeha le matšoenyeho-likarolo tsa boko tse sebetsang ho matlafatsa maikutlo a bohloko.
Lisosa tsa ho hlahloba mahlaseli
Hang ha hypersensitivity ea visceral e thehiloe e le karolo ea bohlokoa ho IBS, bafuputsi ba lebisitse tlhokomelo ea bona ka hore na ke hobane'ng ha e ka ba mokhoa oa ho utloisisa hantle hore na bothata ba IBS ke bofe.
Ho na le likhopolo tse fapa-fapaneng ka mor'a phihlelo ea hypcerensitivity ea visceral ho IBS. Lintho tse ngata li ntse li phenyekolloa, tse kenyeletsang:
- Bohloko bo bakoa ke methapo ea lisele tse koalang mala a maholo
- Liphetoho ho limolek'hule tsa micro RNA tsa lisele tsena
- Liphetoho meleng ea li-neurotransmitter le li-receptors tse ling ka har'a lisele tsena
- Liphetoho litšebelisano pakeng tsa tsamaiso ea methapo e ka hare (boko le mokokotlo oa mokokotlo) le tsamaiso ea methapo ea methapo (litsela le ho tsoa likarolong le mesifa)
- Ho eketseha ha mala ka ho feteletseng (leaky gut)
- Ho ruruha (boemong bo ka tlaase ho se ka bonoang ka ho hlahlojoa ha liteko)
Kutloisiso e molemo mabapi le hore na mekhoa ena e rarahaneng e sebelisana joang e tla lumella ntlafatso ea meriana e tla lebisa tlhokomelo libakeng tsa ho se sebetse 'me e tlise khatello ho matšoao a IBS.
> Mehloli:
> Akbar A, Walters J, Ghosh S. Ts'ebetso ea hypersensitivity e hlakileng ea lefu la maling: mekhoa ea limolek'hule le meriana ea phekolo. Pharmacology & Therapeutics ka 2009 30: 423-435.
> Zhou C, Verne N. Ntho e ncha e utloisisang hore ho na le li-hypersensitivity tsa visceral - litlhoko tsa kliniki ho IBS. Nature Reviews Gastroenterology & Hepatology 2011 8: 349-355.