Bafuputsi ba senola bothata bo ka khonang ho fetela pele ho AIDS ka lilemo tse 3
Le hoja ho se na tsela e behiloeng ka tsela eo HIV e tsoelang pele ho tloha ho motho a le mong ho ea ho e latelang, ho na le mathata (mefuta-futa) e amanang le tsoelo-pele e potlakileng. Lintho tsena tse fapaneng li bakoa ke liphetoho tsa liphatsa tsa lefutso tseo hangata li hlahisang libakeng tse itseng, hangata li jala ka nģ'ane ho sebaka seo e le hore e be tse kholo-ntle ho hang.
Phuputso e phatlalalitsoeng koranteng ea bongaka e bitsoang EBioMedicine e tlalehile hore e 'ngoe e fapaneng joalo e khethiloe Cuba, e tsejoang e e-ba AIDS nakong ea lilemo tse tharo tsa tšoaetso ea pele-e leng ho etsang hore e be mathata a mabifi a khethollang ho fihlela joale.
Ho ea ka tlaleho, bafuputsi ba Univesithing ea Leuven Belgium ba ne ba tseba hantle hore bothata bona bo le CRF19 , e leng mefuta e sa tšoaneng ea HIV e nang le li-subtypes tse tharo tse fapaneng , A, D le G.
Ha hangata HIV e ntse e tsoela pele ho AIDS nakong ea lilemo tse hlano ho ea ho tse leshome ntle le phekolo, CRF19 e bonahala e tsoela pele ka potlako joalo ka ho beha motho kotsing e kholo ea ho kula le lefu pele lefu le qala.
Liphuputso tsa Thuto
Bakuli ba mashome a supileng a metso e 'meli ba ile ba khetholloa ke bafuputsi e le ba hatela pele ka potlako (RP), ba bontša hore ho na le lerotholi le leholo ho CD4 ea bona ho ea ho lisele tse 200 / mL kapa ho bontša boemo ba AIDS (kapa bobeli).
Nako ea bobeli ba bakuli e ne e le lilemo li 34, athe karolelano ea CD4 palo nakong ea ho hlahlojoa e ne e le 276 lisele / mL. Ka lehlakoreng le leng, sehlopha se lekanang sa bakuli ba HIV ntle le sekhetho sa CRF19 se na le palo ea CD4 ea lipakeng tsa 522 le 577 nakong ea ho hlahlojoa.
Ho feta moo, ba hatela pele ka potlako ba ne ba e-na le tšoaetso ea kokoana-hloko ea HIV ho ea ho ba bararo ho feta ba sa tsoe-pele.
Ka lebaka lena, bakuli ba nang le CRF19 ba netefalitsoeng ba na le nako ea bohareng pakeng tsa seroconversion le AIDS ea lilemo tse 1,4 feela ha li bapisoa le lilemo tse 9,8 bakeng sa lilekane tsa bona tse seng tsa CRF19.
Litlhaloso tsa Khatelo-pele e Potlakileng
Bafuputsi ba ile ba khona ho kenyelletsa li-co-factors tse 'maloa tse ka beng li hlalositse tsoelo-pele e potlakileng ea AIDS. Mabapi le palo ea batho, ho ne ho e-na le tsoelo-pele e potlakileng ea ho kopanela liphate ka potlako ho feta batho ba sa etseng ka potlako (49% vs 28%). Ho phaella moo, ha ho na phapang pakeng tsa ho fumanoa ke HIV ka thobalano (li-anal, botšehali) li tsejoe.
Ho itšetlehile ka seo ba se fumaneng, bafuputsi ba lumela hore liphetoho tse potlakileng mofuteng oa CRF19 li ka hlalosa ts'ebetso ena.
Ka kakaretso, ho na le mefuta e 'meli ea li-co-receptors holim'a lisele tse tšoeu tsa mali tse lumellang ho kenella ka HIV seleng: CCR5 le CXCR4 . CCR5 ke motsoako-kholo oo HIV hangata o o sebelisang tšoaetsong ea pele, ha CXCR4 e sebelisoa hamorao tšoaetsong.
Le mefuta e mengata ea CRF19, kokoana-hloko e tlohela ho sebelisa CCR5 ho CXCR4 ka potlako ho feta mathata a mang a HIV . Ka ho etsa joalo, tsoelo-pele ea lefu lena e boetse e potlakile, e lebisang ho nts'etsopele pele ho AIDS.
Liphuputso li tla hloka hore ho be le keketseho ea ho lebelloa ha HIV Cuba, e leng hona joale e nang le tekanyo ea ho feta ea 0,2% (ha e bapisoa le 0,9% US) le tse fetang tse likete tse tšeletseng tse tiisitsoeng.
Ntho e amanang le eona ke hore, ka nako e tloaelehileng ho tloha ho tšoaetso ho ea ho hlahloba ho tloha likhoeli tse 37 ho isa ho likhoeli tse 55, ba boholong ba bophelo ba sechaba ba ka 'na ba sitoa ho khetholla batho ba nang le mefuta e fapaneng ea CRF19 ka potlako ho thibela tšoaetso e potlakileng ea kokoana-hloko.
Le hoja litsebi tsa bophelo bo botle ba sechaba li se li hōlisitsoe hona joale, mefuta e sa tšoaneng e ne e arotsoe Cuba ka morao ka 2005 'me ho ka' na ha etsahala hore e qalile Afrika Bohareng, moo ho neng ho tlalehoa linyeoe tse ngata Angola, Burkina Faso, Cameroon le Togo.
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