Liphoso ka ho Pheta-pheta li ka bopa "Li-virus" tsa "Mutant" ho hanyetsa tšoaetso ea HIV
Ho hanyetsa likokoana-hloko tsa HIV ho hlalosoa feela e le liphetoho ho liphatsa tsa lefutso tsa HIV, tse ka etsang hore likokoana-hloko tse ling li hane ka ho feletseng meriana ea li-antiretroviral . Ha lihlopha tsena tsa likokoana-hloko tsa 'mele li tsoela pele ho hōla, qetellong li fetoha kokoana-hloko e ka sehloohong ka har'a "letamo la likokoana-hloko." Ha sena se etsahala, moriana oa motho ea nang le tšoaetso ea kokoana-hloko ea HIV o tla sebetsa o tlaase ho fihlela phekolo e fela.
Meriana e mecha ea ho loantša likokoana-hloko e atisa ho hlaolela ho hanyetsa butle-butle, le hoja ho se mamele ha lithethefatsi hampe ho ka eketsa menyetla ea ho hanyetsa ka ho lumella kokoana-hloko (akarelletsa likokoana-hloko tsa mutant) hore li se ke tsa etsoa.
Ke hobane'ng ha ho hanyetsa HIV ho etsahala?
Ha lisele li ntse li ikatisa, li iketsetsa likopi tsa tsona, li ntse li eketseha ka potoloho ka 'ngoe. Empa HIV e tloaetse ho etsa liphoso tsa lefutso la liphatsa tsa lefutso, tseo ho tsona likopi li qetellang li senyehile kapa li senyehile. Hangata ha ho joalo, tsena tse fokolang tsa "mutant" li kopitsa kapele.
Leha ho le joalo, maemong a mang a sa tloaelehang, ho fapana le hoo. Ho e-na le ho shoa, likokoana-hloko tse ling li khona ho atleha hobane phetoho ea bona e fetohileng ha e lumelle lithethefatsi tsa HIV ho li kenya, ho kenella kapa ho li tlama. Kahoo le hoja lithethefatsi li khona ho bolaea tšoaetso ea pele (e tsejoang e le "kokoana-hloko ea mofuta o hlaha" ), "liphetoho" tse fetotsoeng li fetoha butle-butle e le hore e be bothata bo boholo.
Ho hanyetsa liphatsa tsa lefutso le hona ho ka fetisoa ho tloha ho motho ho ea ho motho ho ea ka thobalano, ho arolelana litlhoko tsa litlhoko, kapa ho pepesa mali ka ho toba.
Haeba ho hloleha ha kalafo ho hlaha ka lebaka la ho hanyetsa lithethefatsi tsa HIV, lihlopha tse ling tsa lithethefatsi lia ngolisoa ho thibela mefuta e mengata e ka hare ho pholisi ea motho.
Sheba kamoo ho hanyetsa lithethefatsi tsa HIV ho hlahelang kateng tlhahisoleseding, karolo ea leshome slide show .
Tsela ea ho lemoha le ho tiisa ho hanyetsa lithethefatsi tsa HIV
Ho na le liteko tse bonolo tsa mali tse ka lemohang ho hanyetsa tšoaetso ea HIV le ho thusa lingaka hore li fumane hore na meriana e tla sebetsa hantle hokae ho kokoana-hloko ea mutated.
Mefuta e 'meli ea teko ea ho hanyetsa e bitsoang genotypic le phenotypic e leka -lekaneng e khona ho khetholla, ka ho latellana, e leng liphetoho tsa liphatsa tsa lefutso tse etsahetseng le hore na liphetoho tsena li fetoha hakae.
- Litlhahlobo tsa Genotypic li hlahloba liphatsa tsa lefutso tsa kokoana-hloko, pele ka
ho matlafatsa liphatsa tsa lefutso mme joale ho sheba ho bona liphetoho tse teng moo li ka bapisoa le kokoana-hloko ea ho laola. Ka nako eo, setsebi sa mafu se ka lekanya hore na maemo a ho hanyetsa moo a thehiloe ho e 'ngoe kapa tse' maloa tsa liphatsa tsa lefutso tse fapaneng. Liphetoho tse ling tsa "masoabi" li finyella maemo a phahameng a ho hanyetsa, ha tse ling li nkoa e le tse nyenyane ebile li tlatsetsa ho hanyetsanang. - Phenotypic tlhahlobo e fapana le tlhahlobo ea genotypic ka hore e nka kokoana-hloko mme ea e pepesetsa meleng e sa tšoaneng ea meriana ea HIV. Ka ho etsa joalo, e fana ka li-pathologists "tsa sebele-lefats'e," bopaki bo lekaneng ba ho hanyetsa lithethefatsi.
Liteko tsena li tloaelehile ho sebelisoa ho fumana mokhoa o molemo ka ho fetisisa oa phekolo meleng oa pele le mekhoa ea phekolo e latelang ho US le linaheng tse ruileng tse nang le mehloli. Leha ho le joalo, litšenyehelo tsa genotyping le phenotyping li nkoa li le khahlanong le libaka tse ngata tse futsanehileng, tse nang le tšebeliso e fokolang haholo ho bakuli ba sekhukhu.
Hona joale lik'hamphani tse ngata tsa inshorense United States, ka bobeli le tsa sechaba, li lefella tlhahlobo ea genotypic.
Boiteko ba phenotype bo ka 'na ba se ke ba koaheloa ke ba bang ba inshorense. Kamehla hlahloba mofani oa inshorense oa hau ho tiisa hore na liteko tsena li kenngoa meputsong ea hau ea melemo.
Ithute ho eketsehileng ka hore na mofuta oa HIV le oa phenotyping o sebetsa joang .
Lisebelisoa:
Mokhatlo oa Lefatše oa Bophelo (WHO). "Lethathamo la Tšebeliso ea Lithethefatsi ea HIV." Geneva, Switzerland; La 11 April, 2011.
Taniguchi, T .; Nuritdinova, D .; Grubb, J .; et al. "Mofuta oa HIV o sa keneng lithethefatsi o fetisitsoeng o ntse o atile ebile o ama liphello tsa virologic ho sa tsotellehe phekolo ea li-antiretroviral e tataisitsoeng ka genotype." AIDS Patlisiso ea Batho ba Retroviruses. La 5 Khoeli ea 2012; 28 (3): 259-264.
Kuhn, L .; Hunt, G .; Technau, K; et al. "Ho hanyetsa lithethefatsi har'a bana ba sa tsoa fumanoa ba na le tšoaetso ea HIV nakong ea ho ba le tšoaetso e matla ea li-antiretroviral prophylaxis." AIDS. La 30 April, 2014; 8: 1673-1678.
Mekhatlo ea Sechaba ea Bophelo (NIH). "Litaelo tsa tšebeliso ea basebetsi ba li-antiretroviral bathong ba nang le HIV-1-ba nang le tšoaetso le bacha." Bethesda, Maryland; La 11 October, 2013.