Likokoana-hloko tsena li ka 'na tsa Susumetsa, empa ha li Laole Hore Motho a Phethe Li-Hormone
Li-antibodies ke liprotheine tse hlahisoang ke 'mele oa hau tse arabelang kapa li leka ho senya likokoana-hloko, tse leng lintho tse kang likokoana-hloko le libaktheria, tseo' mele o reng ke oa linaha tse ling.
Maemong a mang, 'mele oa hao ka phoso o khetholla liphatsa tsa lefutso, lik'hemik'hale, le litho tsa hau ka ntle. Mofuta ona oa karabelo ke tšobotsi ea lefu la autoimmune , 'me li-antibodies tsena, tse hlaselang' mele oa motho ka tsela e fosahetseng, li bitsoa li-antibodies tsa 'mele.
Sehlopha se seng sa li-antibodies tse ikemetseng ka bomong ke li-antibodies tsa thyroid (TPO) , 'me boteng ba bona ("positivity") bo bontša ho ba teng ha lefu la qoqotho le ikemetseng, hangata Hashimoto's thyroiditis.
Ho utloisisa Hashimoto's Thyroiditis
Ho Hashimoto's thyroiditis, lithibela-mafu tsa TPO li hlasela qoqotho ea thyroid.
Ha nako e ntse e ea, lithibela-mafu tsa TPO li baka ho ruruha 'me qetellong li ka senya tsohle kapa karolo ea qoqotho ea hau ea qoqotho. Ha thyroid e se e sa khone ho hlahisa hormone ea thyroid, butle-butle u ka fetoha hypothyroid. Li-antibodies tsa Hashimoto li ka boela tsa etsa hore qoqotho ea hao e thehe maqhubu, kapa e atolose, e tsejoang e le goiter.
Leha ho le joalo, ho ka nka nako bakeng sa tšusumetso e senyang ea thyroid ea hau ho bonahala ka tekanyo ea teko ea thyroid-stimulating hormone (TSH). Ha ho tloaelehile, ha e le hantle, ho ba le li-antibodies tse nepahetseng tsa TPO likhoeli kapa lilemo pele tekanyo ea hau ea TSH e phahama ho fihlela moo u fumanoang u e-na le hypothyroidism.
Ke habohlokoa hore u bolelle hore batho ba bang ha ba tsoele pele ho ba hypothyroid, ho sa tsotellehe hore ba na le li-antibodies tse ntle tsa TPO.
Mokhoa o nepahetseng oa TPO Li-antibodies, TSH e tloaelehileng: Na Kalafo e tiisitsoe?
Ka kakaretso, haeba ts'ebetso ea hau ea TSH e le e tloaelehileng (pakeng tsa 0,4 le limilione tse 4,5 ka lihora tse ngata ka hora ea lithara, kapa mU / L), phekolo (e nang le qoqotho ea lihomone tsa qoqotho) ha ea lokela, esita le haeba li-antibodies tsa TPO li nepahetse.
Leha ho le joalo, haeba TSH ea hao e phahame ka bokhutšoanyane (a re re hovering hoo e ka bang 6.0mU / L) le hormone ea thyroxine (T4) e tloaelehile, "positivity" ea li-antibodies tsa TPO e ka susumetsa ngaka ea hao hore e qale kalafo ea lihomone tsa qoqotho. Lebaka ke hore kalafo ea pele e ka thibela tsoelo-pele ea sena seo ho thoeng ke subclinical hypothyroidism ho overt hypothyroidism.
Ngaka ea hau e ka 'na ea qhekelloa haholo ho tšoara hypothyroidism ea hau e ka tlaase mona haeba u e-na le matšoao a kang mokhathala, ho imeloa kapa ho tepella maikutlong, kapa u na le boloetse bo bong bo ikemetseng, ka mohlala, lefu lena la leliac.
Lilemo le tsona li tla phetha karolo ea qeto ea ngaka ea hau. Ka tloaelo, ho na le sebaka se phahameng sa ho qala moriana oa qoqotho ho fetola meriana ho batho ba hōlileng, hobane setsi sa bona sa motheo TSH se holimo meeli e tloaelehileng.
Lentsoe le Tsoang ho
Ntlha ea bohlokoa mona ke hore li-antibodies tse ntle tsa qoqotho li bontša mokhoa o ikemetseng; Leha ho le joalo, ke feela selae sa pie ea qoqotho 'me ha e le hantle o laela hore na u hloka phekolo ea hormone ea qoqotho kapa che. Ho e-na le hoo, li ka 'na tsa u susumetsa le qeto ea ngaka ea hao, har'a tse ling tse kang lilemo tsa hao, histori ea lelapa le matšoao.
Ka kakaretso ho molemo ho buisana le ngaka ea hau ka liphetho tsa hau tsa laboratoire le matšoao a hau.
Ka tsela ena o ka etsa bonnete ba hore o matlafatsa thyroid le bophelo bo botle ka kakaretso.
> Mehloli:
> Braverman, L, Cooper D. Werner & Ingbar's The Thyroid, ea 10. WLL / Wolters Kluwer; 2012.
> Davies TF. Pathogenesis ea Hashimoto's thyroiditis (e sa foleng autoimmune thyroiditis). Ross DS, ed. E maemong. Waltham, MA: UpToDate Inc.
> Garber, J, Cobin, R, Gharib, H, et. al. "Litlhahiso tsa Bophelo ba Meriana ea Tlhahlobo ea Hystothyroidism ho Batho ba baholo: Lingoliloeng tsa American Association of Clinical Endocrinologists le American Thyroid Association li buuoa ka tsona." Boitšoaro ba Endocrine. Tsela ea 18: 6 November / December 2012.
> Jonklaas J et al. Litaelo tsa Phekolo ea Hypothyroidism: E hlophisitsoe ke American Thyroid Association Task Force e ncha sebakeng sa Thyroid Hormone. Thyroid . 2014 Dec 1; 24 (12): 1670-1751.
> Kent, Athol. "Likokoana-hloko tsa Thyroid tse Amanang le ho Nyala le Pele ho Ntoa." Litlhahlobo ho Litho tsa Bokoetliso le Gynecology 4.3-4 (2011): 128-129. 2011.