Alpha-ketoglutaric acid ke ntho e fumanoang ka tlhaho meleng oa motho. Hape e fumanoang ka mokhoa oa phepo ea lijo, alpha-ketoglutaric acid e phetha karolo ea bohlokoa phetong ea Krebs (letoto la liphetoho tsa lik'hemik'hale tse amanang le tlhahiso ea matla ea 'mele). Alpha-ketoglutaric acid e tlatsetsa ho fana ka melemo e mengata ea bophelo bo botle.
Alpha-ketoglutaric acid e boetse e hlaha ka mofuta oa letsoai, e leng ntho e bitsoang alpha-ketoglutarate.
Alpha-ketoglutarate e kenyelletsoa ho thehoa ha glutamine, amino acid e hlokehang bakeng sa protheine synthesis le bakeng sa ho sebetsa hantle ha sesole sa 'mele.
Lisebelisoa
Hangata Alpha-ketoglutaric acid e boleloa ho ntlafatsa ts'ebetso ea lipapali. Ba bang ba buellang phekolo ea meriana ba bolela hore tšebeliso ea alpha-ketoglutaric acid e ka thusa ho susumetsa tlhahiso ea 'mele ea protheine, ho tsitsisa tsoekere ea mali nakong ea boikoetliso, le ho ntlafatsa ho ikoetlisa.
Mefuteng e meng ea phekolo, alpha-ketoglutaric acid e boetse e boleloa ho thusa ka mathata a latelang a bophelo bo botle:
- tšoaetso ea baktheria
- likotsi
- lefu la liphio
- mafu a tomoso
Melemo
Le hoja lipatlisiso tse mabapi le bophelo bo botle ba alpha-ketoglutaric acid li fokotsehile haholo, lipatlisiso tse ling tsa pele li bontša hore alpha-ketoglutarate e ka fana ka melemo e itseng ea bophelo bo botle. Mona re shebile lintlha tse 'maloa tse fumanoang liphuputsong tse fumanehang:
1) Hemodialysis
Alpha-ketoglutarate e ka 'na ea e-ba le molemo o itseng ho batho ba fetang hemodialysis.
Phuputsong e phatlalalitsoeng koranteng ea Nephron ka 1996, bafuputsi ba fumane hore ho fana ka motsoako oa alpha-ketoglutarate le calcium carbonate ho bakuli ba hemodialysis ho thusitse ho matlafatsa metabolism ea amino le ho fokotsa hyperphosphatemia (boemo bo tšoaetsanoang ke maemo a sa tloaelehang a phosphate maling).
2) Ho Buuoa ka Meriana
Alpha-ketoglutarate e ka thusa ho ntlafatsa mosebetsi oa liphio har'a bakuli ba etsoang ke lefu la pelo, ho ea ka phuputso ea 1998 e tsoang Annals ea Thoracic Surgery . Thuto e ne e kenyelletsa batho ba 22 ba nang le ts'ebetso e tloaelehileng ea liphio pele ba etsoa opereishene ea pelo. Bakeng sa bakuli bao, batho ba 11 ba ile ba kenngoa ka tšohanyetso ea alpha-ketoglutarate ka hora ka mor'a ho buuoa. Liphello tsa thuto li bontša hore alpha-ketoglutarate e ka ntlafatsa tšollo ea mali liphio.
3) Lilemo tse telele
Phuputso ea 2014 e hatisitsoeng ka tlhaho e fana ka maikutlo a hore alpha-ketoglutarate e ka 'na ea bontša tšepiso ho eketsa nako e telele ea bophelo. Litekong tsa meriana ea Nematode Caenorhabidis elegans , bangoli ba thuto ba ile ba etsa qeto ea hore alpha-ketoglutarate e sitisa tlhahiso ea matla a cellular mme e etsisa liphello tsa lijo tse nyenyane haholo lik'halori, tse bontšitsoeng ho eketsa nako ea bophelo ba liphoofolo tse itseng. Ho ea ka babali ba lipatlisiso, alpha-ketoglutarate e matlafalitse nako ea bophelo ea libōkō tse tšoaroang ka hoo e ka bang karolo ea 50 lekholong holim'a taolo e sa sebetsanoeng. Ho boetse ho hlokahala thuto e eketsehileng ho bona hore na litholoana li tla ba le liphello life ho batho.
Lithako
Ka lebaka la ho hloka lipatlisiso, ha ho tsejoe hanyenyane ka polokeho ea tšebeliso ea nako e telele kapa e tloaelehileng ea li-supplement tse nang le alpha-ketoglutaric acid.
Leha ho le joalo, ho na le taba e itseng ea hore tšebeliso ea alpha-ketoglutaric acid e ka halefisa 'mele le / kapa ea ferekanya mpa.
Ke habohlokoa ho hopola hore lisebelisoa ha li e-s'o hlahlojoe polokeho le lijo tse ling tsa lijo tse ngata li sa tsamaisoe ka molao. Maemong a mang, sehlahisoa se ka fana ka tekanyo e fapaneng le ea tekanyo e boletsoeng bakeng sa setlama se seng le se seng. Maemong a mang, sehlahisoa sena se ka 'na sa silafatsoa le lintho tse ling tse kang tse ling. Hape, polokeho ea liphallelo ho basali ba nang le bakhachane, bo-'mè ba tlhokomelo, bana, le ba nang le maemo a bophelo kapa ba noang meriana ha e e-s'o thehoe.
U ka fumana litlhahiso tse eketsehileng tsa ho sebelisa li-supplements mona .
Mekhoa e meng
Mefuta e meng ea phekolo ea tlhaho e ka 'na ea sebelisoa ho ntlafatsa tshebetso ea lipapali. Ka mohlala, lipatlisiso tse ling li bontša hore branched-chain amino acid e ka thusa ho ntlafatsa ts'ebetso ea 'mele le ho thibela mokhathala nakong ea nako e telele ea boikoetliso.
Ho phaella moo, li-supplementary phosphatidylserine li fumanoe ho matlafatsa matla a ho ikoetlisa, le ho fokotsa mesifa le ho sireletsa khahlanong le keketseho ea cortisol (hormone e lokolotsoeng nakong ea khatello ea kelello) e atisang ho bakoa ke ho tlōla tekano.
Hape ho na le bopaki ba hore pōpo e ka eketsa tshebetso ka matla a phahameng, mesebetsi e khutšoanyane (e kang ho phahamisa boima le sprinting).
Moo U ka e Fumanang
E fumaneha ho reka Inthaneteng, alpha-ketoglutaric acid e rekisoa ka libakeng tse ngata tsa tlhaho tsa lijo, lihlahisoa tsa lithethefatsi, le mabenkele a khethehileng a li-supplement.
Lentsoe le Tsoang ho
Ka lebaka la lipatlisiso tse fokolang, ho haufinyane ho buella alpha-ketoglutaric acid bakeng sa boemo leha e le bofe. Ke habohlokoa ho hlokomela hore ho itlhokomela ka bophelo bo botle ka alpha-ketoglutaric acid le ho qoba kapa ho lieha ho hlokomela tlhokomelo e tloaelehileng ho ka ba le liphello tse tebileng. Haeba u nahana ho e sebelisa, etsa bonnete ba hore u buisane le ngaka ea hau.
Lisebelisoa
HONG H, HONG H, HONG H, HONG H, HONG H, HONG H, HONG H, HONG H, HONG H, HONG H, HONG H, HONG H, HONG H, HONG H, DENG G C, Quach A, Nili M, Krall AS, Godwin HA, Chang HR, Faull KF, Guo F, Jiang M, Trauger SA, Saghatelian A, Braas D, Christofk HR, Clarke CF, Teitell MA, Petrascheck M, Reue K, Jung ME, Frand AR, Huang J. "The α-ketoglutarate ea metabolite e eketsa nako ea bophelo ka ho thibela ATP synthase le TOR." Tlhaho. 2014; 509 (7500). dx.doi.org/10.1038/nature13264
Jeppsson A, Ekroth R, Friberg ea P, Kirnö K, Milocco I, Nilsson FN, Svensson S, Wernerman J. "Litla-morao tsa alpha-ketoglutarate pele ho ts'ebetso ea likorone." Ann Thorac Surg. 1998 Mar; 65 (3): 684-90.
Riedel E, Nündel M, Hampl H. "Kopo ea Alpha-Ketoglutarate ho bakuli ba hemodialysis e ntlafatsa metabolism ea amino acid." Nefrone. 1996; 74 (2): 261-5.
Taba e nepahetseng: Boitsebiso bo boletsoeng setšeng sena bo reretsoe merero ea thuto feela 'me ha bo nkele sebaka keletso, ho hlahlojoa kapa kalafo ke ngaka e nang le tumello. Ha e reretsoe ho koahela mekhoa eohle ea tlhokomelo, likamano tsa lithethefatsi, maemo kapa liphello tse bohloko. U lokela ho batla thuso ea meriana hang-hang bakeng sa bophelo bo botle le ho buisana le ngaka pele u sebelisa mefuta e meng ea phekolo kapa u etse phetoho tsamaisong ea hau.