Ha lisele tsa mali li ntse li hōla, "malapa" a sa tšoaneng a tsoa mahlaheng a bakoang ke mali. Moeli oa seleng oa myeloid o tšoantšetsa lelapa le leng le joalo. Lisele tse seleng ea myeloid cell line ke tse hlahang liseleng tsa myeloid, mme qetellong e tla ba lisele tse khethehileng tsa mali, tse bontšitsoeng mona:
- Basophils
- Neutrophils
- Eosinophils
- Li-monocyte (tse teng maling)
- Macrophages (e teng ka mahlahahlaha a fapaneng)
- Erythrocyte (lisele tse khubelu tsa mali)
Ka hona, e 'ngoe le e' ngoe ea lisele tse ka holimo e emela sehlahisoa sa ho qetela kapa phello ea ho hōla lelapeng la myeloid.
Ke mohala oa myeloid cell o amehang "myeloid malignancies" e kang mafu a myelogenous leukemia (AML) , a nang le palo e phahameng ka ho fetisisa ea liteko tsa selemo le selemo, le lefu le sa foleng la leememia (CML) , e leng li-diagnostic tse ka bang 6,660 tse selemo sa United States.
Moelelo
Lisele tse khubelu , lisele tse tšoeu tsa mali le liplatelete kaofela li behile lintho tse lebeletsoeng bophelong, 'me li nkeloa sebaka ka ho tsoelang pele. Lisele tse bakoang ke mali - tse lulang mobung oa masapo ho batho ba baholo - ho atisa le ho hlahisa batho ba sa tšoaneng, kapa meloko ea lisele.
Lisele tsohle tsa mali tse hōlileng tsebong li ka fetisa moloko oa tsona ho ea selefouno e le 'ngoe, selefouno ea hematopoietic stem (HSC) e ngata, e leng ntho e tšoanang le "Adama le Eva" ea lisele tsohle tsa mali.
Lisele tsena tse hlahang li arola -a bobeli ho iketsetsa sebaka le ho theha "lisele tsa moloko." Ka lebaka leo, har'a litloholo tsa HSC ke mefuta e sa tšoaneng ea lisele tsa bolokoa: ho na le motho ea tloaelehileng ea lymphoid le moemeli ea tloaelehileng oa myeloid. Tsela ena e pakeng tsa lymphoid le myeloid lineages ke e kholo.
Moloko e mong le e mong a ka etsa hore malapa a bona a arohane a lisele tsa mali. Lisele tse tšoeu tsa mali tse tsejoang e le lymphocyte li hlaha ho tloha ho lymphoid progenitors, ha lisele tse tšoeu tsa mali tse tšoeu, lisele tse khubelu tsa mali le liplateletsi li hlaha ho tloha ho li-progenitors tsa myeloid. Lisele tsa myeloid li atisa ho etsa hoo e ka bang 85% ea lisele tsa marore, ka kakaretso.
Myeloid Malignancies
Ho ea ka American Cancer Society, bakuli ba bangata ba nang le lefu lena la myeloid leukemia (AML) ba na le lisele tse ngata tse sa tšoeu tsa mali maling a bona, 'me ha li na lisele tse khubelu tsa mali kapa li-platelet. Lisele tse ngata tsa mali tse tšoeu li ka 'na tsa e-ba myeloblasts - hangata li bitsoa ho phatloha- e leng lisele tse sa tšoaneng tsa mali tse sa tloaelehang tse fumanoang mali a potolohileng. Lisele tsena tse sa sebetseng ha li sebetse joaloka lisele tse tloaelehileng tsa mali tse tloaelehileng.
Bakuli ba bangata ba nang le kankere e sa foleng ea myeloid (CML) ba na le lisele tse ngata tse tšoeu tsa mali tse nang le lisele tse ngata tsa pele, tse sa tsoaneng. Tse ling tsa lisele tse tšoeu tse sa tšoaneng li ka boela tsa phatloha empa hangata li teng ka palo e nyenyane ho feta ka AML. Ka linako tse ling bakuli ba CML ba ka 'na ba e-ba le litekanyo tse tlaase tsa lisele tse khubelu tsa mali kapa liplatelete tsa mali
Ka bobeli ba AML le CML, lisele tsa mali li ka ba le maikutlo a kotsi a kankere ea mali, empa ho hlahloba ka ho hlaka ho hloka hore bone ea bone e be ea aspirate le liteko tse ling.
Lisebelisoa
Krumsiek J, Marr C, Schroeder T, et al. Differentiation Hierarchical of Myeloid Progenitors Is Encoded In Network Transcription Factor Network. PLoS One. 2011; 6 (8): e22649.
Eaves CJ. Lisele tsa masapo a Hematopoietic: likhopolo, litlhaloso, le 'nete e ncha. Mali . 2015; 125 (17): 2605-2613.
Orkin SH, Zon LI. Hematopoiesis: Paradigm e Khanyang ea Bioloji ea Sekala sa Stem. Cell . 2008; 132 (4): 631-644.
Jagannathan-Bogdan M, Zon LI. Hematopoiesis. Ntlafatso (Cambridge, Engelane) . 2013; 140 (12): 2463-2467.
Mokhatlo oa Kankere oa Amerika. Ho thoe'ng ka lefu le kotsi la myeloid le lefu la mali? E fihlile ka December 2015.
Williams, L. "Tlhahlobo e hlakileng ea Hematopoiesis le Immunology: Tlhahiso ea Hematopoietic Stem Cell Transplant Receivers" ka Ezzone, S. (2004) Hematopoietic Stem Transplantation ea Li-Cell: Lekhotla la Booki ba Koetlisang Oncology Lekala la Booki: Pittsburgh, PA (pp.1- 12).