Le hoja palo e kholo ea phumama e bakoa ke ho ruruha ha li-eosinophilic, bakuli ba nang le matšoao a semoa ba bakoa ke lisosa tse ling tsa ho ruruha (mohlala, basophils , lymphocytes , kapa neutrophils ) ha ba fumane monyetla oa ho hlahlojoa ke FeNO. Ho ea ka Clinical Practice Guideline e tsoang ho American Thoracic Society, FeNO e ka sebelisoa ho hlahloba ho ruruha le tšehetso e saosophiopong ho fumanoa ke lefu la asthma haeba ho hlokahala bopaki bo utloahalang.
Ka ho toba, maemo a phahameng a FeNO a bontša ho ruruha matšoafong le hore mokuli a ka 'na a arabela li-steroid tse tsitsitseng tse thehiloeng lipatlisisong tse fetileng. Ka hona, FeNO e hlalosa ka ho nepahetseng karabo ea phekolo ho e-na le ho etsa hore motho a fumane lefu la asthma.
Mathata le Tlhahlobo ea Tloaelelo
Merero e mengata ea likarolo tsa poro e ntse e khannoa ke matšoao a phallo kapa tlhōrō ea phallo. Matšoao a tloaelehileng a kang ho laola , sefuba , ho khohlela le ho fokola ha moea ho ka ba thata haholo ebile ha ho amane le ho ruruha ha sebele matšoafo a hau. Phallo ea tlhōrō e ka 'na ea lumellana ka bonolo le tekanyo ea ho ruruha ha moea ho ea ka lipatlisiso tse ling.
Melemo ea FeNO Bakeng sa ho Hlahloba Phala ea Mafu
Hoo e ka bang halofo ea linyeoe tsohle tsa asthma li akarelletsa ho ruruha ha sefofane sa eosinophilic. Mofuta ona oa ho ruruha o bakoa ke ho phahama ha lisele le lisele tse ling tse eketsang ka ho khetheha litekanyetso tsa okside tsa nitric.
Joalokaha ho boletsoe pejana, bakuli ba nang le ho ruruha ha li-eosinophilic ba phahamisitse litekanyetso tsa FeNO, ha bakuli ba nang le ho ruruha ho tsoa lintlheng tse ling ba sa phahamisa maemo a FeNO. Ho phaella moo, lipatlisiso li bontšitse ho ruruha ho hlakileng ho bakuli ba maemong a phahameng a FeNO. Ka lebaka leo, litekanyetso tse phahameng tsa FeNO li nahanoa ho khetholla bakuli ba ka 'nang ba arabela kalafo ea steroid le lipatlisiso ba bontšitse hore litekanyetso tse phahameng tsa FeNO ke tse ling tsa likarabo tse ntle.
Maemo a FeNO
Litekanyetso tsa FeNO li ntse li lekanngoa liofising tsa ngaka. Bakuli ba hlaphoheloa ka ho feletseng 'me joale ba phefumoloha ka mokhoa o tloaelehileng ka har'a sesebelisoa se lahloang. Litekanyetso tsa FeNO li fumaneha ka metsotso e seng mekae bakeng sa tlhaloso ke ngaka ea hau.
Mekhahlelo e tloaelehileng, e bohareng le e phahameng e hlahisoa tafoleng e ka tlase.
| Batho ba baholo | Bana | |
|---|---|---|
| 12 le ho feta | 4-12 | |
| E tlaase | <25 | <20 |
| Bohareng | ≥ 25- ≤ 50 | ≥ 20- ≤ 35 |
| E phahameng | > 50 | > 35 |
| ppb = likarolo tse limilione tse likete | ||
FeNO Sebelisa Tlhokomelo ea Tlhaho
Mokhatlo o hlophisitsoeng oa tlhokomelo ea meriana oa Optimum oa Mokuli ke boitsebiso ba United States bo nang le ho phefumoloha ho nang le litaba tse sa tsejoeng, tse fumanoang nako e telele bakeng sa bakuli ba asthma UK. Lefapha la basebetsi le ile la hlahlojoa ho khetholla bakuli ba sa amoheleng phekolo ea steroid empa ba ka 'na ba rua molemo le bakuli ba neng ba laoloa ka tsela ea meriana ho sebelisa FeNO e le letšoao.
Bafuputsi ba fumane hore lingaka tse nyane tsa lingaka tsa tlhokomelo ea mantlha li tšoara porofalo e sebelisa FeNO. Hoa thahasellisa hore ho sebelisa tlhahlobo ea FeNO ho amahanngoa le ho eketseha ho khomarela taolo ea phekolo ho phaella tšebelisong ea eona ho qalisa phekolo ea steroid e sa tšoaetsanoeng kapa setšoantšo sa phekolo ea mehato. Ho phaella moo, lipatlisiso tse ling li bontšitse hore tekanyo ea ho hlaseloa ha li-astma e tlaase ho feta ho bakuli ba sebelisang FeNO e le karolo ea leano la bona la ho shebella.
Phuputso e entsoeng United States litsing tse 10 tsa asthma e fumane hore mokhoa oa FeNO o entse hore ho be le litekanyetso tse phahameng tsa steroid tse haelitsoeng ho bapisoa le tsamaiso e tloaelehileng e thehiloeng ho tataiso ea asthma, empa e ile ea fana ka ntlafatso e kholo ea matšoao a asthma ao lingaka li neng li le bohlokoa.
> Mehloli:
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> Dwelk RA, Boggs PB, Erzurum SC le al. Tlhahiso-pele ea Tlhahlobo ea Kelello ea ATS ea Tlhahlobo ea Kelello: Tlhaloso ea Litekanyetso tsa Oxide ea Exitled Nitric (FENO) bakeng sa Lik'hamphani tsa Kliniki.
> Mokhatlo oa Lefatše oa Pherefatsi: Leano la Lefatše la ho laola le ho thibela phumama. 2012.
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> Langley SJ, Goldthorpe S, Custovic A, Woodcock A. Likamano pakeng tsa tšelo ea mali, bronchial reactivity, le ho tlosoa ke nitric oxide ho sehlopha se seholo sa bakuli ba asthmatic.Tlhahisano ea ho Fokotsa ho Phekola ha Meriana Immunol2003, 91: 398-404.
> National Heart, Lung le Blood Institute. Tlaleho ea Panel ea litsebi 3 (EPR3): Litaelo tsa Tlhahlobo le Tsamaiso ea Pherefatsi.
> NHLBI / WHO Workshop Report: Leano la lefatše la ho laola le ho thibela phumama. Bethesda, MD. Mekhatlo ea Sechaba ea Bophelo. National Heart, Lung le Setsi sa Mali; 1995. Phatlalatso ea No. 95-3659.