Nodular sclerosing Hodgkin lymphoma, kankere ea lisele tsa lymph, ke mofuta oa lefu la Hodgkin. Ke mofuta o tloaelehileng ka ho fetisisa oa Hodgkin lymphoma linaheng tse tsoetseng pele, o etsang karolo ea 60 ho isa ho 80 lekholong ea batho bohle ba anngoeng ke lefu lena.
Nodular sclerosing Hodgkin lymphoma e ama boholo ba bacha le bacha ba baholo. Hape ke ntho e tloaelehileng haholo ho banana ho feta bashanyana.
Lebitso 'nodular sclerosing' le tsoa ho ponahalo ea lisele tsa lymph node tlas'a microscope ea mofuta ona oa Hodgkin lymphoma.
Matšoao a matšoao a nodular sclerosing Hodgkin lymphoma a atolosoa lymph nodes molala, marang-rang kapa ka har'a sefuba . Ho fumanoa ha lymphoma ho entsoe ka ho ruruha ha lymph node biopsy.
Batho ba bangata ba fumanoa ka mekhahlelo ea pele ' me ba ka phekoloa ka phekolo e akarelletsang chemotherapy le phekolo ea mahlaseli.
E 'ngoe ea Lymphomas tse' maloa tse sa tšoaneng tsa Hodgkin
Mabitso a mefuta eohle ea lymphoma le li-subtypes li ferekanya esita le ho lingaka tse sa sebetsaneng le tsona kamehla. Lefu la Hodgkin le Hodgkin lymphoma le bolela ntho e le 'ngoe, leha ho le joalo, ho na le mefuta e sa tšoaneng ea lymphoma, eo Hodgkin e leng eona feela. Hape ho na le mefuta e sa tšoaneng ea Hodgkin lymphoma, hape. Ka hona, ho na le ho fokotseha ha nodular sclerosing Hodgkin lymphoma ka moo e lumellanang le setšoantšo se seholoanyane sa lymphomas:
Likarolo tse peli tsa motheo tsa lymphoma ke Hodgkin le Non-Hodgkin lymphoma.
Hodgkin lymphoma e ka boela ea fokotseha ka lihlopha tse peli:
- Classic Hodgkin lymphoma - e nang le likaroloana tse 'maloa
- Hodgkin lymphoma e sa tloaelehang ea lymphocyte
"Nodular lymphocyte e kholo" le "nodular sclerosing" ha li tšoane - li bua ka mefuta e 'meli e sa tšoaneng ea Hodgkin lymphoma.
Nodular Sclerosing Hodgkin lymphoma - e leng lymphoma e hlalositsoeng hona joale - ke karoloana ea Classic Hodgkin lymphoma. Classic Hodgkin lymphoma e na le lihlopha tse 'nè tse latelang:
- Litlhaku tse sa tloaelehang
- Lisele tse ferekaneng
- Moruo oa lymphocyte
- Lymphocyte-e felile.
Litlhaloso: Nodular Sclerosing Classic Hodgkin Lymphoma
Nodular sclerosis Hodgkin lymphoma (NSHL) ke karolo e tloaelehileng ka ho fetisisa ea likokoana-hloko ho bacha le bacha ba baholo linaheng tse tsoetseng pele. NSHL e boetse e na le karolo e matla ea ho futsaneha, e nang le kotsi e fetang 100 ho feta mafahla a tšoanang.
Morao tjena, ho bile le thuto e kholo e entsoeng ka mokhatlo oa mahlaseli a kotsi a tsoang letsatsing le likarolo tse sa tšoaneng tsa Hodgkin lymphoma. Phuputsong ea Emily Bowen le basebetsi-'moho le eena, Hodgkin lymphoma e ne e le tlase haholo ho lihlopha tsa batho ba nang le letsatsi le phahameng ka ho fetisisa la letsatsi. Le hoja ho fumanoa sena e ne e le tšekamelo, feela, mokhoa ona o ile oa bonahala o sebetsa ho batho ba nang le subtype ea nodular sclerosis.
Liphuputso tse ling tsa morao-rao li 'nile tsa hlahloba phekolo e itseng, thibelo ea' mele ea ho itšireletsa mafung, le kamoo e ka sebelisanang le mekhoa e sa tšoaneng e tsejoang e ntse e tsoela pele ka mefuta e meng ea HL ea khale.
Phuputso e entsoeng ke Peter Hollander le basebetsi-'moho le eena e ile ea bolela hore ho thibela ho itšireletsa mafung ho thibela lefu la mokhahlelo oa lefu (PD) -1 ke mokhoa o mocha oa phekolo ka ho khutlela morao le ho hlokomoloha classic Hodgkin lymphoma.
Sehlopha sena se fumane hore litšobotsi tse itseng tsa lisele tse fumanoang ho pota-potile hlahala, eseng tsa lisele tse hlabang, li ne li amana le ho hlaseloa. Phuputso eo e fumane hore liphello tsa HL tsa khale li ne li le mpe haholoanyane ha lisele tsena tse tšoeu tsa mali, kapa lisele tsa microenvironment li ne li lekana haholo ho etsa PD-1 le PD-L1. Ba ile ba etsa tlhahiso ea hore lihlopha tsena tsa bakuli li ka rua molemo mefuteng e mengata e matla ea chemotherapy, mohlomong, ho tloha ho PD-1 inhibitors e le phekolo ea pele.
> Mehloli:
> Cozen W, Li D, Molemo ka ho fetisisa T, et al. Meta-analysis meta-analysis ea nodular sclerosing Hodgkin lymphoma e hlahisa kotsi ea loci ka 6p21.32. Mali. 2012; 119 (2): 469-475.
> Hollander P, Kamper P, Ekstrom K, et al. Matla a phahameng a PD-1 + le PD-L1 + leukocyte a Hodgkin lymphoma microenvironment ea khale a amahanngoa le liphello tse fokolang. Keletso ea mali. 2017; 1 (18): 1427-1439.
> Bowen EM, Pfeiffer RM, Linet MS, le al. Kamano pakeng tsa mahlaseli a kotsi a mahlaseli a kotsi le Hodgkin lymphoma subtypes United States. British Journal of Cancer. 2016; 114 (7): 826-831.