Tsamaiso, Morero, le Mathata a PBSCT
Tlhaloso ea PBSCT
Lintho tsa phetoho tsa mali tsa sesepa tsa mali, kapa tsa PBSCT, ke mekhoa e tsosolosang lisele tsa stem tse senngoeng ke lithibela tse phahameng tsa chemotherapy. Lisele tsa masela ke lisele tse hlahisang lisele tsa mali - lisele tse khubelu tsa mali tse jereng oksijene, lisele tse tšoeu tsa mali tse thusang 'mele ho loantša tšoaetso, le liplatelete tse thusang hore mali a koaloe.
E ne e kile ea e-ba hore li-transplant cell stem li ne li tsoa mongoaneng o fanoeng . Le hoja boholo ba liseleng tsa stem li teng masong a mangata, tse ling li tsoa ka potlako - mokokotlong oa mali. Tsena li ka bokelloa mme li fetisetsoa ho bakuli ho tsosolosa polokelo ea tsona ea sele ea stem. Boholo ba li-cell stem transplants (empa eseng kaofela ka mabaka a mangata) hona joale ke tsa PBSCT. Pele o fana ka lisele tse hlabang, bafani ba fuoa meriana e eketsang palo ea lisele tse bakoang maling. Lisele tsa mali tsa mali li sebetsa hantle haholo ha li bapisoa le li-transplant tsa mongobo, 'me ha e le hantle, maemong a mang li ka' na tsa baka liplatelete le mofuta oa lisele tse tšoeu tsa mali tse tsejoang e le li-neutrophils "ho nka" le ho feta, ha mofani a sa amana le mofani .
Morero oa Li-transplant tsa Cell
E le hore u utloisise hantle hore na li-transplant cell stem li sebetsa joang, li ka thusa ho bua ka ho eketsehileng ka hore na lisele tse boima ke life.
Joalokaha ho boletsoe ka holimo, lisele tsa stem - tse tsejoang hape e le li-cell stem tsa hematopoietic - li hlahisa mefuta eohle e sa tšoaneng ea lisele tsa mali 'meleng. Ka ho kenya li-cell stem tse ka 'nang tsa khetholla le ho fetoha mefuta e fapaneng ea lisele tsa mali - mokhoa o bitsoang hematopoiesis - ho kenngoa ho ka fetola ho haelloa ke mofuta o mong le o mong oa lisele tsa mali.
Ka lehlakoreng le leng, phekolo ea meriana ea ho fetola lisele tsena kaofela li matla ebile li na le mathata a mangata. Ka mohlala, o ka fa tšelo ea platelet, mali a khubelu ea tšelo ea mali, 'me o fana ka meriana ea ho susumetsa bobeli ba lisele tse khubelu tsa mali le lisele tse tšoeu tsa mali, empa sena se matla haholo, se thata,' me se na le litla-morao tse ngata le mathata.
Mabaka a PBSCT
Chemotherapy e fanoang ka litekanyetso tse phahameng li bolaea kankere hantle, empa e boetse e senya lisele tsa masapo tse teng lerung la bone. Li-transplant cell stem li thusa ho tsosolosa mofu oa masapo e le hore mokuli a ka mamella tekanyo e phahameng ea chemotherapy.
Mefuta
Ho na le mefuta e meraro ea ho kenyelletsa li-stem cell:
- Li-autologous transplantants: ha bakuli ba fumana li-cell tsa bona tsa bakoang.
- Li-allogeneic transplants: ha bakuli ba fumana li-cell stem ho mor'abo, morali'abo bona, kapa motsoali. Mofani ea sa amaneng le eena a ka sebelisoa.
- Li-syngeneic transplants: ha bakuli ba fumana li-stem tsa masela a bona a tšoanang.
Ho fana ka lisele tsa mali tsa mali
Monehelo oa PBSC o kenyelletsa ho fetisa metsoako ea mali ea mali, ho e-na le lisele tse tsoang mokong oa masapo, kahoo ha ho na bohloko ba ho kena mokong oa masapo. Empa ho PBSC, meriana e fuoeng ho matlafatsa palo ea lisele tsa stem ho potoloha ha mofani eo e ka amahanngoa le lik'hemik'hale tsa 'mele, mesifa ea mesifa, hlooho ea hlooho, le matšoao a kang a mafu.
Litla-morao tsena hangata li emisa matsatsi a 'maloa ka mor'a tekanyo ea ho qetela ea meriana e matlafatsang li-stem.
Mathata a PBSCT
Ho na le mathata a mangata a khonehang a PBSCT. K'hemotherapy e phahameng ea tekanyo pele ho transplant e beha kotsing e tebileng ea tšoaetso ka lebaka la ho haelloa ke lisele tse tšoeu tsa mali (ho itšireletsa mafung) le mathata a amanang le ho haelloa ke lisele tse khubelu tsa mali (mali a mali) le liphaseletsi tse khubelu (thrombocytopenia).
Kotsi e tloaelehileng ka mor'a hore motho a fetisetsoe ke lefu la sefate sa greft versus host (GvH), e leng se etsahalang ka tekanyo e itseng hoo e batlang e le li-transplant tsohle tsa stem. Matšoaong a GvH lisele tse fetisitsoeng (ho tsoa ho mofani) li lemoha motho ea amohelang (ea amohelang ho kenya setopo) e le linaheng tse ling, le ho hlasela.
Ka lebaka lena batho ba fanoa ka lithethefatsi tse itšetlehileng ka 'mele ka mor'a ho fetisetsa sele ea stem.
Leha ho le joalo lithethefatsi tsa immunosuppressive li boetse li beha likotsi. Ho fokotseha ha karabo ea 'mele ea mmele ka lebaka la lithethefatsi tsena ho eketsa kotsi ea mafu a tebileng, hape ho eketsa kotsi ea ho hlahisa lik'hemik'hale tse ling.
Mekhoa e meng
Ho etsa PBSCT ke mokhoa o moholo. Hase feela hore e ka pele ho chemotherapy e mabifi, empa matšoao a lefuba le ho tšoaroa ke lefu, le mathata a lithethefatsi tsa immunosuppressive e etsa hore e be mokhoa o atisang ho boloka o monyenyane, 'me ka kakaretso o phetse hantle, batho.
Khetho e le 'ngoe e ka nkoang bakeng sa bakuli ba tsofetseng kapa ea bophelo bo sekiselitsoeng ke ho fetisetsoa ha semoablative stem cell cell. Mokhoa ona, ho e-na le ho felisa mokoallo oa masapo o nang le chemotherapy e phahameng haholo, ho sebelisoa chemotherapy e tlaase haholo. Sephiri sa mefuta ena ea li-transplants ha e le hantle se itšetlehile ka mofuta oa greft againstus host disease. Leha ho le joalo, ho e-na le ho kenngoa ha lihlopha - lisele tsa stem tse fetisitsoeng - ho hlasela lisele tse "ntle" meleng ea batho ba amohelang, lisele tsa stem tse fetisitsoeng li hlasela lisele tsa kankere meleng ea ba amohelang. Boitšoaro bona bo bitsoa "greft versus tumor."
E boetse e tsejoa e le:
PBSCT, Phaliso ea mali ea li-cell stem
Melao e amanang:
HSCT = haematopoietic stem cell transplantation
HCT = ho fetisetsa seleng ea hematopoietic
SCT = ho kenyelletsa seleng ea stem
G-CSF = Lebaka le hlasimollang la Granulocyte-kolone - ntlha ea ho hōla, meriana e matlafatsang li-cell stem, eo ka linako tse ling e fuoang bafani ho bokella lisele tsa mafura a hematopoietic ho tloha lefung la bone ho ea ho mali a phetseng.
Lisebelisoa:
National Cancer Institute. Ho fetisetsa Cell Cell Stem. E ntlafalitsoe ka 04/19/15. http://www.cancer.gov/about-cancer/treatment/types/stem-cell-transplant
Singh, V., Kumar, N., Kalsan, M., Saini, A., le R. Chandra. Mechanism of Induction: Inthaneteng ea Li-cell Stripotent (IPSCs). Journal ea Li-cell Stem . 2015. 10 (1): 43-62.
Wu, S., Zhang, C., Zhang, X., Xu, Y., le T. Deng. Na phallo ea mali kapa marotholi a masapo ke mohloli o molemo oa lisele tsa stem bakeng sa ho fetisetsa litlama maemong a bafani ba sa amaneng le HLA? Tlhahlobo ea meta. Tlhahlobo e Bohlokoa ho Oncology le Hematology . 2015. 96 (1): 20-33.