Lintho tse fapaneng le li-transplant tsa Mini le Growth vs Tlhahiso ea Malignancy
Mekhoa e seng metsoabelative stem cell transplants, kapa "li-transplants tse nyenyane," ke mofuta o batlang o le ocha oa allogeneic peripheral stem cell transplant e sa hlokeng ho felisa marora ho isa tekanyong ea li-stem cell transplants.
Kamoo ba Sebetsang Kateng
Mekhoeng e tloaelehileng ea cell cell transplants, bakuli ba fuoa tekanyo e phahameng haholo ea chemotherapy, kapa ntle le mahlaseli a kotsi, ho hlakola, kapa "ablate," moorong.
Joale li fuoa lisele tse hlabang tsa mofani bakeng sa ho tsosolosa tlhahiso ea sele ea mali le ho itšireletsa mafung.
Lipatlisiso li bontšitse hore tekanyo e matla ea chemotherapy le mahlaseli a kotsi a fanoeng ka mekhoa e tloaelehileng ea li-stem cell e ka 'na ea se ke ea e-ba eona feela ntho e ikarabellang bakeng sa katleho ea bona kaneng ea kankere. Mekhoa e seng metsoabelative stem cell transplants e sebelisa tekanyo e nyenyane haholo ea chemotherapy ho finyella sephetho se setle.
Graft vs. Malignancy
Molao-motheo oa katleho e ka atlehang ea ho kenyelletsa mofuta ona o bitsoa "greft-versus-malignancy" (GVM), "matlapa-ho-tumor" kapa "phello ea matla a ho phekola-leukemia". Hang ha masela a bakoang ke mofani a kenngoa ho motho ea mo amohelang, tsamaiso ea 'mele e "ncha" ea' mele e hlokomela hore lisele tse ling tse setseng tsa kankere li sa tloaeleha ebile lia li senya.
Phapang Ho Tsamaiso ea Li-cell Stem ea Semoablative
Liphetoho tse seng li-myeloablative li fapane ka ho khetheha ho se etsahalang pele ho ho fetisoa. Ha li bapisoa le li-myeloablative transplants, li-mini-transplants li sebelisa lisebelisoa tse ngata tse tlaase le tse nyenyane tsa chemotherapy le mahlaseli a kotsi, li lateloa ke ho tšeloa ha lisele tse hlabang.
Ts'ebetso ena e sebelisa monyetla oa ho hlahisa liphello tse mpe ka ho fetisisa ha e ntse e le chefo ho ea mo amohelang.
Joaloka mekhoa e tloaelehileng ea li-cell stem, li-transplants tse nyenyane li boetse li na le kotsi ea ho kenngoa lihlahisoa le ho tšoaroa ke mafu , moo lisele tse fetisitsoeng li bonang lisele tsa hau e le linaheng tse ling le ho hlaseloa.
Lisebelisoa
Ho kenyelletsa mofuta ona e ka ba khetho e ntle bakeng sa bakuli ba baholo kapa ba nang le maemo a mang a bophelo a ka etsang hore ba sitoe ho mamella liphello tse kotsi tsa chemotherapy ea liphetoho tse tloaelehileng.
Ho fetisetsa li-semoabelative stem cell cell ho ka boela ha e-ba le karolo ho phekola bakuli ba kotsing le kankere e kotsing e kholo, e kang mafu a myelogenous leukemia , kapa ba kileng ba khutlela morao ka mor'a ho fetisoa ha stem cell cell.
Bafuputsi ba boetse ba shebile katleho ea ho se fetisetsoa ha semoablative stem cell cell ho bakuli ba nang le kankere ea 'mele e matla, e kang lebese le liphio, hammoho le maemo a mang a bongaka a kang multiple sclerosis.
Kaha ho nka nako e telele hore lisele tse fanoeng li fumanehe, li-transplant ha li sebelisoe ha kankere e boemong ba eona bo tsoileng pele ka ho fetisisa.
Katleho
Li-transmlant tse seng tsa myeloablative li 'nile tsa sebelisoa ho tšoara mefuta e fapaneng ea kankere ea mali, ho akarelletsa le Hodgkin le e seng Hodgkin lymphoma, myeloma le leukemia. Litefiso tsa likarabo li fapane lithuto.
Ena ke mokhoa o mocha haholo, le oa pele o etsoa ka tlaase ho lilemo tse 20 tse fetileng, kahoo ho na le lipatlisiso tse fokolang tsa nako e telele tse fumanehang bakeng sa melemo le likotsi tse amanang le mofuta ona oa ho kenyelletsa. Leha ho le joalo, liphello tsa pele tse tšepisang li fana ka tšepo ho bakuli ba neng ba ke ke ba khona ho fetisetsa sesepa sa stem , haholo-holo ba pakeng tsa lilemo tse 50 le 75.
Lisebelisoa:
Neiss, D., Duffy, K. "Melemo ea motheo ea ho kenya limela" ho Ezzone, S. (2004) Ho hlatsoa ha li-cell mahlaseli a Hematopoietic: Buka ea Booki. Mokhatlo oa Oncology oa Booki. Pittsburg, PA (maq. 13-21).
Duke Medicine. Mali a batho ba baholo le Marrow Planting. Setlhare sa Phaliso ea Mokuli ea Mamello ea Mamello ea Mamello ea Allogene. https://www.dukemedicine.org/sites/www.dukemedicine.org/files/nonmyeloablative_allogeneic_transplant_patient_handbook.pdf
Kasamon, Y., Bolanos-Meade, J., Prince, G. et al. Liphello tsa ho se na mokhoa oa ho itšireletsa ka mali oa HLA-Mali kapa Marrow Ho kenya limela ka holimo-limola ka mor'a ho fetisetsa Cyclophosphamide ho Batho ba baholo. Journal of Clinical Oncology . La 10 August, 2015. (E hatisitsoe inthaneteng pele e hatisoa).