Pilisi ea ho Kopanela Liphate Flibanserin e Khabisoa ka Drama
Ho baetsi ba eona, flibanserin, pilisi e pinki e lebisang ho libido tsa basali le e entsoeng ke Sprout Pharmaceuticals, ke mohlala o mong feela oa lefu la ho lla. Mafu a fetisisang a bua ka tloaelo ea lik'hamphani tsa meriana le ba bang ba "pathologi" likarolo tsa boemo ba motho e le hore ba etse buck. Ka mohlala, halitosis kapa phefumoloho e mpe e ile ea fetoha boemo bo neng bo hloka phekolo ka mor'a hore Listerine e ntlafatsoe ho "tšoara".
Leha ho le joalo, ho batšehetsi ba eona, bothata ba botona kapa botšehali ba ho kopanela liphate ke lefu la sebele, 'me flibanserin e ka thusa. Batšehetsi bana ba bua ka mahlomola a bakoang ke koloi ea thobalano e fokotsehileng kapa e seng teng.
Sepheo sa ho Kopanela Liphate ke Mosali / Arousal Disorder?
Bothata ba botona kapa botšehali ba botona kapa botšehali bo bolela ho fokotseha kapa ho se be le thahasello ea thobalano ho mosali ea nkang likhoeli tse tšeletseng kapa ho feta 'me o bakela mathata a mang kapa a mang. Ho feta moo, ho se tsotelle ho joalo ho ke ke ha e-ba le tšoaetso ea lefu le leng (nahana ka lefu la tsoekere kapa ho tepella maikutlo) kapa lithethefatsi (nahana ka ho imeloa kelellong). Ke habohlokoa hore tahlehelo ena ea takatso ea ho kopanela liphate e baka mahlomola kapa bothata hobane, ho seng joalo, hase bothata. Ha e le hantle, batho ba bangata ba na le thahasello e telele ea ho kopanela liphate e sa bakeng mathata a botho, 'me sena se ntle.
Bafuputsi ba bolela hore bothata ba botona kapa botšehali ba ho kopanela liphate bo tsosang boko bo sebetsang bo sebetsanang le ho fumana meputso.
Ha e le hantle, boemo bona bo ama litsela tsa frontostriatal le lisebelisoa tsa neuronal tsa insula, amygdala, hypothalamus le ventral striatum. Basali ba nang le thahasello e joalo ea thobalano le litaba tse tsosang takatso, tšusumetso ea thobalano le menyaka e ameha hampe. Tlhokomeliso, moputso oa ho hlahisa likarolo ho mathata a mang a kelello ho akarelletsa ho tepella maikutlo, schizophrenia, tšebeliso e mpe ea lithethefatsi, 'dementia', mathata a ho ja le mathata a mang a thobalano.
Ho thahasellisang ke hore bafuputsi ba fumane liphetoho merianeng e sebetsang e bontšang hore ho na le mathata a macrocircuit a bakoang ke litakatso tsa botona kapa tsa botšehali tsa botona kapa botšehali. Ka mohlala, basali ba fumanoa ba e-na le bothata bona bo sa tloaelehang libakeng tsa boko le libaka tsa bokooa.
Flibanserin e Sebetsa Joang?
Ho thata haholo (ho ke ke ha khoneha) hore bo-rasaense ba lekanyetse maemo a itseng a neurotransmitter likarolong tse sa tšoaneng tsa boko. Leha ho le joalo, ha ho sebelisoa mekhoa ea microdialysis le li-node ka har'a marang-rang a boko, bafuputsi ba bolela hore flibanserin e eketsa ho lokolloa ha dopamine le norepinephrine le ho fokotsa ho lokolloa ha serotonin ho basali ba nang le thahasello ea thobalano le takatso. Ka ho khetheha, flibanserin e ka khetholla pakeng tsa li-receipt serotonin le ho susumelletsa serotonin 5HT1A receptors ha e thibela serotonin 5HT2A receptors ka prefrontal cortex e leng ho eketsa ho lokolloa ho tlaase ha dopamine le norepinephrine. Kamoo ho bonahalang kateng, liphello tsena tsa motsoako oa li-neurotransmitter li thusa ho laola moputso oa ho ntlafatsa le ho eketsa basali ba libido.
Ka ho khetheha, flibanserin e sebetsana le li-neurotransmitters, eseng li-hormone. Le hoja li-hormone li ipakile li atlehile ho matlafatsa libido, liphello tse mpe li etsa hore li be kotsi haholo joaloka phekolo.
Ho feta moo, flibanserin hase "Viagra ea basali." Tlhekefetso e sebetsa ka ho phahamisa mali ho ea liphatseng tsa lefutso ho sebelisa mekhoa e fapaneng e fapaneng le ho ama sebaka se itseng sa liketso (liphatsa tsa lefutso le bokooa).
Liphello tse tsoang litsing tse peli tsa litsing tsa bophelo tsa meriana tse bitsoang BEGONIA le DAISY (ah, mabitso a lipalesa ... a monate hakaakang!) A bontša hore flibanserin e ka eketsa libido tsa basali. Li kopantsoe, liteko tsena tse laoloang ka tsela e sa tloaelehang le tse behiloeng sebakeng se seng li ile tsa hlahloba basali ba 3548 ba nang le thahasello ea thobalano le ts'oaetso e tsosang takatso. Ka mor'a libeke tse 24 tsa phekolo ea letsatsi le leng le le leng ka 100 mg flibanserin, liketsahalo tse khotsofatsang tsa thobalano, takatso ea botona le botšehali le mahlomola a bakiloeng ke takatso e tlaase ea ho kopanela liphate li ile tsa hakanngoa ho sebelisa lipotso tse fapaneng (tse ikhethang).
Bafuputsi ba ile ba hlokomela hore ho barupeluoa ba nkang flibanserin-ha ba bapisoa le ba ntseng ba e-ba teng-ho ne ho e-na le keketseho ea likamano tse ngata tse khotsofatsang tsa thobalano le boemo ba takatso ea thobalano le ho fokotseha mahlomoleng a bakoang ke takatso ea ho kopanela liphate.
Liketsahalo tse bohloko ka ho fetisisa litsing tsena li bile teng ka tlase ho karolo ea 1 lekholong ea barupeluoa, 'me ha ho le e' ngoe ea liketsahalo tsena tse tebileng e neng e bakoa ke phekolo ea flibanserin ka boeena. Tlas'a liphello tse tebileng tse tebileng, ho kenyelletsoa ho ba le botenya, ho nyekeloa ke pelo, mokhathala le ho robala (ho tloaelehileng haholo).
Tlhahlobo e 'ngoe e laoloang ke batho ba nang le bothata ba ho kopanela liphate e bitsoang SNOWDROP (Ke bona mohlala, mona ... lebitso le leng la lipalesa!), Le hlahloba basali ba 949 ba postmenopausal ba nang le thahasello ea botona kapa botšehali ea botona kapa botšehali (DSM-IV- Tlhaloso ea nako e fetotsoeng ho thahasello ea thobalano / ts'oaetso e tsosang takatso ea DSM-5). Joaloka liteko tse ling, liphello li bontša hore flibanserin e ntlafatsa takatso ea thobalano, liketsahalo tse ngata tse khotsofatsang tsa thobalano le ho fokotsa khatello ea thobalano kaofela ha e ntse e baka liphello tse seng kae tse bohloko. Ka ho khetheha, basali ba 37,6 lekholong ba flibanserin le 28,0 lekholong ea basali ba ntseng ba nka placebo ba tlaleha liketsahalo tse khotsofatsang tsa thobalano.
Le hoja ho tse ling tsa lipatlisiso bafuputsi ba ile ba leka ho kenyelletsa barupeluoa ba noang meriana e loantšang maikutlo, li-antihypertensives, li-triptan le likokoanyana tse ling tse thibelang likokoana-hloko, moeli o le mong o moholo oa lithuto tsena ke khethollo ea mehlala. Ka mantsoe a mang, hobane mathata a ho tsosa takatso ea thobalano le takatso a atile mme a ama mefuta eohle ea basali, ho ne ho le thata ho hlahloba hore na flibanserin e sebetsa ho bohle.
Ha a bua ka ho ameha ka tšireletseho le katleho, FDA e hanne ho lumella flibanserin ho hanyetsa ka makhetlo a mabeli ao moetsi oa eona, Sprout Pharmaceuticals le ba bang ba sebetsanang le eona. Ho latela phekolo ea meriana, ke hlile ke utloana le mathata a FDA. Ha e le hantle, lisebelisuoa tsa flibanserin tse nang le li-neurotransmitters tse 'maloa le ho nahana hore basali ba bangata ba tla noa lithethefatsi le bona ba tla nka lithethefatsi tse ling tse tsoelang pele ho fetola litekanyetso tsa methapo ea kutlo ea pelo - joaloka li-anti-depressants le khatello ea kelello - ho molemo ho nka maikutlo.
Qetello
Batho ba bangata ha ba tsebe hantle hore na ba lokela ho nahana ka flibanserin. Ka lehlakoreng le leng, batho ba bangata ba belaella lik'hamphani tsa meriana le boikemisetso ba bona 'me ba bolela hore haeba ba amoheleha, flibanserin e ka fetisoa ho basali ba bang ba kang ba sa tšoenyeheng ba amanang le ho fokola ha takatso ea thobalano kapa ho tsosoa. Tlhahisoleseding e amanang le eona, ntho e 'ngoe le e' ngoe e mabapi le papatso ea limela ea flibanserin e lla ka ho kopanya lipilisi le lipalesa tsa lipilisi tsa lipilisi. Ka lehlakoreng le leng, ho thata ho utloisisa liphello tsa flibanserin ntle le haeba u mosali ea sebelisang lithethefatsi.
Lisebelisoa:
Sehlooho se nang le sehlooho se reng "Ts'ebetso le polokeho ea flibanserin ho basali ba postmenopausal ba nang le bothata ba ho ba le takatso ea ho kopanela liphate ka maikutlo a boikaketsi: liphello tsa nyeoe ea SNOWDROP" ka JA Simon le bo-mongoli ba kopanetsoeng ba hatisitsoeng ho Menopause: Journal of The North American Menopause Society e hatisitsoeng ka 2013.
Sehlooho se ngotsoeng "Mehato ea ketso ea flibanserin, setsebi sa mefuta-futa ea serotonin le mohanyetsi (MSAA), ka khathatso ea takatso ea ho kopanela liphate ka boikaketsi" ke SM Stahl e phatlalalitsoeng ho CNS Spectrums ka 2015.
Sehlooho se reng "Ho ntlafatsa menyetla ea ho phekola boloetse ba takatso ea ho kopanela liphate (HSDD) boemo ba nts'etso-pele ea flibanserin" ea J Thorp, Jr, le bangoli ba li- BJOG tse hatisitsoeng ka 2014.