PMNs: Lelapa la Lisele tsa Motsoeu
KE ENG?
Polymoricone leukocyte, kapa PMNs, ke lelapa le khethehileng la lisele tse tšoeu tsa mali. Lelapa le kenyeletsa lisele tsa 'mele tse tsejoang e le li-neutrophils, li-eosinophil le li-basophil. Li-neutrophils, basophil le li-eosinophil ke li-PMN tse ka fumanoang li potoloha maling. Ka tlhahlobo ea tlhahlobo ea mali, leha ho le joalo, PMN e tloaelehileng ka ho fetisisa ke ea neutrophil.
P o o M o o H o o Hl o bolela eng?
Ntle le li-PMN tse buang ka sehlopha sa li-cell, lebitso leo le boetse le bua ka ponahalo ea bona. Poly + morph e amana le "libopeho tse sa tšoaneng" le nyutlelie e bua ka nuclei ea sele ea PMN, ha e silafatsoa le ho shejoa tlas'a microscope. Ka hona, PMNs e tsejoa ka mokhoa o sa tloaelehang oa libopeho tseo li-nuclei tsa tsona li ka li etsang. Nuclei ea PMN lisele tse tšoeu tsa mali li na le likarohano tse tebileng hoo ho e-na le ho shebahala se setle, selikalikoe se pota-pota sefapanong, se ka 'na sa bonahala se na le lilobe tse peli kapa tse tharo. Ts'ebetso ena e nkiloeng e etsa hore ponahalo ea "lehe le halikiloeng," e tloaelehileng le mefuta e meng e mengata ea li-cell, e be e le sieo-ho e-na le hoo, sele e shebahala joaloka lehe le nang le yolk le robehileng ha le ntse le pheha.
Na Granulocytes ea PMNs?
E. Ho phaella ho nuclei e tsosang takatso, PMNs e boetse e na le likhaseli tse ka bonoang ho sebelisa li-dae le mahlaseli; li-granules li tšoana le libone tse nyenyane ka har'a seleng, 'me li fana ka ponahalo ea tsona ea mafura ka PMN.
Ka lebaka lena, li-PMN li boetse li bitsoa "li-leukocyte tsa granular" kapa granulocytes. Seo se ka hare ho granules se itšetlehile ka hore na u bua ka PMNs. Tabeng ea li-neutrophils, li-granules li na le li-enzyme le lintho tse nang le likokoana-hloko tse thibelang likokoana-hloko tseo, ha li lokolloa, li thusa ho loantša tšoaetso.
Li-PMN li tsoa hokae?
Li-PMN hammoho le mefuta e meng ea lisele tse tšoeu tsa mali, lisele tse khubelu tsa mali le liplatelete kaofela li theoha kapa li hlahisoa ho tloha lisele tsa hematopoietic stem marong. Ho tswa ho li-cell stem tsa hematopoietic, lisele tsa mali li arohana ka litsela tse peli tse kholo, tse fapaneng: lisele ea lymphoid e tsoelang pele e e-ba lymphocyte, le myeloid cell line , e hlahisang mefuta e sa tšoaneng ea PMN, ho phaella ho lisele tse ling tsa mali.
Li Fumaneha Hokae?
PMNs ke lisele tse tšoeu tsa mali tse ka fumanoang maling. Leha ho le joalo, lisele tse tšoeu tsa mali hangata li khona ho latela lik'hemik'hale tsa lik'hemik'hale, li fallela liketsong tse fapaneng 'meleng moo li hlokahalang, u ka boela ua fumana li-PNN libakeng tse ling, tse kang libakeng tsa tšoaetso kapa ho ruruha.
Na kaofela li Sebetsoa ka Tsela e Tšoanang?
Che, e 'ngoe le e' ngoe ea lisele tse tšoeu tsa PMN e na le karolo e fapaneng ea bophelo bo botle le mafu, 'me e ka kenella mekhoeng e fapaneng tsamaisong ea' mele ea ho itšireletsa mafung, le hoja ho na le ho kopana ho itseng. Joalo le lisele tsohle tse tšoeu tsa mali, PMN e tšoanang e ka 'nang ea thusa ho itšireletsa mafung le ho loantša tšoaetso, maemong a mang, e ka ba le karolo likarabong tse ka bang kotsi kapa tse sa leka-lekaneng, tse kang ho phekola ha meriana le likarabo tse tebileng.
BA ETSA ENG?
Ha e tluoa ho bakuli ba nang le kankere, li-neutrophils ke PMN ea bohlokoahali ho loantša tšoaetso. Ha e le hantle, ke bona ba bohlokoa ka ho fetisisa ba kenyang tšoaetso ea HIV, e leng nako, ho ea ka American Cancer Society. E le hore u fumane lintlha tse ntle tsa palo ea hau ea neutrophile, lingaka li sebelisa tekanyo e bitsoang palo e feletseng ea neutrophile, kapa ANC. Motho ea phelang hantle o na le ANC pakeng tsa 2 500 le 6 000.
Mesebetsi ea neutrophils le tse ling tsa PMN e hlalositsoe ka tlase:
- Neutrophils - Neutrophils e ka pele ea tšireletso khahlanong le libaktheria, likokoana-hloko le mafu a fungal, 'me ke tsona tsa pele tse hlahang sebakeng seo. Ha ho e-na le kotsi e entsoeng ka 'mele, lintho tse bitsoang' chemotactic 'li lokolloa tse khahlang li-neutrophils.
- Li-Eosinophils - Li-Eosinophil li sebetsana le liphello tse sa lumellaneng le likokoana-hloko tsa likokoana-hloko tse kang likokoana-hloko. Litekanyetso tse phahameng tsa li-eosinophil tse maling li ka bakoa ke maemo a mang, hape, tse kang liketso tsa lithethefatsi.
- Basophils - Basophil e boetse e ameha ka liphetoho tse fokolang , 'me li senya histamine le metsoako e meng e bakang ho ruruha le ho thibela mali ho thibela mali. Li-basophil ke tsona tse nang le mali a lekanang le mali, a nang le lisele tse nyenyane (li-basophils li maling;
Lisele tse Mast ka Mathateng:
- Lisele tse nyenyane - Linthong tse ling, lisele tse ngata li phetha karolo ea bohlokoa ho maemo a phefumolohang le a lijo . Lisele tse ngata li teng lihlopha tse peli tse kholo: lihlahisoa tse sebetsang le li-mucosal. Lihlopha tse peli tsa subtypes li ka lokolla granules pele. Libaka tsa mucosal ke li-linings, tse kang lesela la mala, kapa lesela la lifofane. Lisele tsa puisano li na le tse tebileng ho feta li-linings tsena le likarolong tse ling, hape. Maemong a mabeli a mahlakoreng a mabeli, lisele tse ngata li ka sebelisoa 'me tsa fokotseha, kapa tsa furalla moputso oa li-granules. Lintho tse ka hare ho li-granules li sebetsa joaloka lisele le ho sebetsa li kopane le lisele tse ling tsa 'mele.
Ho eketsehileng ho PMNs le Immunine
Li-PMN ke karolo ea tsamaiso ea 'mele ea ho itšireletsa mafung e sa tloaelehang. Seo se bolelang ke hore ba tšoara bohle ba kenang ka tsela e tšoanang. Lentsoe lena innate le bolela hore tsamaiso ena e teng ho tloha ho tsoalo - lisele ha li hloke ho ithuta ho hlokomela bahlaseli. Lia li hlokomela ho tloha ha li e-ea.
Sena se fapana le tsamaiso ea 'mele ea ho itšireletsa mafung. Mokhoa oa 'mele oa ho itšireletsa mafung, masole a' mele a ho itšireletsa mafung a ka ithuta ho lemoha mohlaseli 'me a beha tšoaetso ea' mele ea ho itšireletsa mafung. Hangata karabo e rarahane ebile e na le mefuta e mengata, e akarelletsang lisele tsa 'mele tse tsejoang e le B le T lymphocyte, hammoho le lisele tsa antigen tse hlahisoang, kapa li-APC, tse ikarabellang ho lemosa lymphocytes mabapi le boteng ba antigen e tsoang linaheng tse ling.
Maemo a Amehang Maemong a sa Tšoaneng a PMNs
- Matšoao a phahameng a neutrophils maling a atisa ho bakoa ke maloetse, ha lisele tsena li bitsoa ho sireletsa 'mele.
- Ha 'mele o se na li-neutrophils tse lekaneng, sena se ka tsamaisana le kotsi ea motho ea ho ba le tšoaetso. Meriana e meng ea phekolo ea kankere e ka etsa hore mefuta ea neutrophil e oe, e leng se hlahisang se tsejoang e le neutropenia. In neutropenia e bakoang ke chemotherapy, bahlokomeli ba bophelo bo botle ba lebela kotsi ea tšoaetso ka litsela tse sa tšoaneng.
- Hangata li-eosinophils li bitsoa eosinophilia , 'me hangata li bakoa ke liphello tse fokolang, liphello tsa lithethefatsi kapa mafu a likokoana-hloko,' me hangata ke kankere le maemo a mang. Ho haella ha lisele tsena ho tloaelehile.
- Ho fetela ha li-basophil ho ka etsahala ka hypothyroidism le ka kankere ea mali. Mathata a mang a amanang le litekanyetso tse ngata tsa basophil a kenyelletsa lefu la Crohn le lefu la ulcerative-malapa a mabeli a nkiloeng ke lefu la ho ruruha.
Lisebelisoa:
Kurashima Y, Kiyono H. Nako e ncha ea li-mucosal mast cells: karolo ea tsona ho ho ruruha, likarabo tsa 'mele ea ho itšireletsa mafung le nts'etsopele ea li-adjuvant. Mekhoa ea ho leka-lekanya le ea molecular (2014) 46, e83.
Mokhatlo oa Kankere oa Canada. Anatomy le physiology ea mali. E fihlile ka 02/24/16. http://www.cancer.ca/en/cancer-information/cancer-type/leukemia/anatomy-and-physiology/?region=on
Williams, L. "Tlhahlobo e hlakileng ea Hematopoiesis le Immunology: Tlhahiso ea Hematopoietic Stem Cell Transplant Receivers" ka Ezzone, S. (2004) Hematopoietic Stem Transplantation ea Li-Cell: Lekhotla la Booki ba Koetlisang Oncology Lekala la Booki: Pittsburgh, PA (pp.1- 12)