Lisele ea lymphoid e na le lisele tsa mali tse qalang lerung la masapo ka mokhoa o bitsoang hematopoiesis, 'me li theoha seleng e tloaelehileng ea lymphoid.
Hematopoiesis
Ho hlahisoa ha "lisele tsohle tsa mali" ho qala mofuteng oa masapo ka mokhoa o tsejoang e le hematopoiesis . Ka mokhoa ona, mefuta eohle ea lisele tsa mali e simoloha seleng ea stem ea hematopoietic .
Sele ena ea pele, eo hape e bitsoang sekala sa stement, e ka tšoantšoa le Adama ka Bibeleng, e le "sele ea ntate" eo lisele tse ling tsohle tsa mali li hlahisoang ho tsona. Lisele tsena li boetse li bitsoa pluripotent stems lisele, tse bolelang hore li na le menyetla ea ho ba mefuta e fapaneng ea lisele.
Ntho ea pele ea lisele e etsahala ha sele ena ea pluripotent e latela e 'ngoe ea litsela tse peli tsa nts'etso-pele tse bitsoang li-line line. Selefouno ea stripotent stem e ka khetholla ho e ka bang moeli oa seleng oa myeloid kapa lisele tsa lymphoid.
Cell ea Stem Lymphoid - Lymphoblast
Mohala oa lymphoid o qala ka lisele tsa lymphoid stem, e tsejoang hape e le lymphoblast kapa lymphoid progenitor cell. Ena ke fereko e kholo tseleng, ha lisele tsohle tse molaong ona li qala ka sele ea lymphoid, ha lisele tsohle tsa myeloid line (tse kang neutrophils, macrophages le lisele tse khubelu tsa mali) li qala ka sele ea myeloid progenitor.
Lisele tsa Lisele tsa Lymphoid
Selefu ea lymphoid progenitor (lymphoblast) e ka qetella e fapane ka ho khetheha ho tse khethehileng haholoanyane ho lisele tse akarelletsang:
- Li-lymphocyte B - Li-lymphocyte tsa B kapa "L lisele li sebetsa ho sireletsa 'mele oa hau ho tsoa ho tšoaetso ka ho hlahisa li-antibodies.
- Lymphocyte T - T lymphocyte, kapa "L cells" ke lisele tsa 'mele oa ho itšireletsa mafung tse fumanoang, ho bolaea le ho hlophisa ntoa khahlanong le litaba tse ling tse kang libaktheria, likokoana-hloko le lisele tsa kankere.
- Selefu ea tlhaho ea bolaeang - Lisele tsa tlhaho tsa tlhaho ke lisele tse mabifi tsa tsamaiso ea 'mele ea ho itšireletsa mafung e sebetsang ho felisa lisele tsa kankere le lisele tse nang le tšoaetso ea kokoana-hloko.
Cell Line ea Lymphoid le ho itšireletsa mafung
Lisele tsa li-lymphoid li hlahisa hoo e batlang e le 15% ea lisele tse nang le mofu o phetseng hantle. Lisele tsa masapo a Hematopoietic li tsoela pele ho khetholla lisele tsa lymphoid tse tsoetseng pele tse tsoelang pele li arohana ka lisele tse hōlileng tse hlahisang lisele tsa lymphoid. Ho hakanngoa hore mofu oa masapo o fetola lisele tse tšoeu tsa mali tse limilione tse 100 ka hora.
Lymphoid Malignancies
Lichelete tse amanang le lisele tsa lymphoid li kenyelletsa:
- Li-non-Hodgkin lymphomas - Li-lymphomas tseo e seng tsa Hodgkin li na le sehlopha sa mefuta e sa tšoaneng ea lymphomas tse ka kenyang li-cell tsa B kapa lisele tsa T. Lik'hemik'hale tsena li behoa litsong tse leshome tse supileng tsa mafu a amanang le kankere bakeng sa banna le basali.
- Hodgkin lymphomas - Hodgkin lymphomas le tsona ke kankere e tloaelehileng haholo, 'me hona joale ke kankere e tloaelehileng ka ho fetisisa e fumanehang ho bacha ba pakeng tsa lilemo tse 15 le tse 25.
- Lefu la lefu le nang le lymphocytic (ALL) - Acute lymphocytic leukemia ke kankere e kenyang lymphoblasts - lisele tse tsoelang pele ho ba lisele tsa B, lisele tsa T, le lisele tse bolaeang tsa tlhaho. E atile haholo ho bana ba ka tlase ho lilemo tse leshome empa e ka ba teng ka nako efe kapa efe.
- Chronic lymphocytic leukemia (CLL) - Chronic lymphocytic leukemia ke kankere e United States e amang haholo lymphocyte B. T cell CLL, ka lehlakoreng le leng, e atile haholo likarolong tsa Japane.
Lisebelisoa:
> Liu, A., Wang, Y., Ding, Y. le al. Ho Khaola: Holo ea Hematopoietic ea Lehlakoreng la Tlhahlobo le Litsamaiso Tse Tloaelehileng tsa Lymphoid Ho Hlokahala ho Hloka Hematopoietic-E nkiloeng, T-cell TLR4 e le Mohlala oa Bophelo bo sa Feleng ba Endelloxin. Journal of Immunology . 2015. 196 (6): 2524-8.
Sieff, C. Tlhaloso ea hematopoiesis le cell cell stem. E maemong. E ntlafalitsoe ka la 05/26/15. http://www.uptodate.com/contents/overview-of-hematopoiesis-and-stem-cell-function
Liang, H., le J. Zuniga-Pflucker. Hematopoiesis: ho tloha qalong ho ea boemong ba ho tsosolosa mafung. Tlhahlobo ea Lekala la Stem & Therapy . 2015. DOI: 10.1186 / s13287-015-0051-z