Tsela ea pele ea TNF Blocker e amohelehang bakeng sa ramatiki ea ramatiki ka 1998
Enbrel (etanercept) ke phetoho ea li-biologic modifier (e nchafatsoa ea motho ea hlahisang tumor necrosis factor protein fusion). Enbrel e hlahisitsoe ka liphatsa tsa lefutso ho tšoana le li-receptors 'meleng tse tlama tumor necrosis factor (TNF-alpha). Enbrel e sebetsa ka ho tšela TNF e feteletseng pele e ka kopanya li-receptor tsa tlhaho.
TNF-alpha ke cytokine e amehang ts'ebetsong ea ho ruruha.
Nako e feteletseng ea TNF-alpha e amahanngoa le ramatiki ea ramatiki le mefuta e meng ea ramatiki ea ho ruruha .
Lithethefatsi tse joalo
Enbrel e ne e le moriana oa pele oa anti-TNF 'me o ile oa amoheloa ka 1998 bakeng sa ramatiki ea lefu la masapo le mefuta e itseng ea ho ruruha ha ramatiki. Remicade (infliximab) e ne e le ea bobeli ea TNF inhibitor e amohelehang ke US Food and Drug Administration ka 1999. Humira (adalimumab) e ile ea amoheloa ka 2002. Simponi (golimumab) e ile ea amoheloa ke FDA ka la 24 April, 2009. Cimzia (certolizumab pegol ) e ne e amoheloa ke FDA ka la 14 May, 2009.
Enbrel e thehiloe ka ho kenyelletsa DNA ea batho ka li-cell phone hamster tsa mahaena le ho theha protheine ea liphatsa tsa lefutso. Remicade e sebelisa liprotheine tsa batho le li-mouse bakeng sa ho etsa semerica monoclonal antibody . Humira o sebelisa liprotheine tsa batho ka ho feletseng le phapone e bonts'a theknoloji ho hlahisa li-antibodies tse monoclonal.
Tsamaiso
Enbrel e tsamaisoa e le ente e ka tlaase kapa hanngoe beke le beke (matsatsi a 3 kapa a 4 ka thōko).
Litekanyo tse fanoang li itšetlehile ka maemo a tšoaroang. Enbrel e tlameha ho laeloa ke ngaka ea hau 'me e hloka hore inshorense e fane ka tumello. Enbrel e ka sebelisoa hammoho le methotrexate ho bakuli ba sa arabeleng methotrexate feela.
Kemiso e ngotsoeng
Enbrel e amohetsoe ho sebetsana le ramatiki ea methapo ea mali e itekanetseng ho isa bohōleng bo tebileng, ho ea boemong bo bobebe ho bana ba nang le ramatiki , lefu la psoriatic , ankylosing spondylitis , ea sa foleng psoriasis e sa foleng.
Morero o khothaletsoeng
Bakeng sa batho ba baholo ba nang le ramatiki ea lefu la masapo, ramatiki ea psoriatic le sponyylitis ea ankylosing, tekanyo e tloaelehileng ea Enbrel ke 50 mg ka beke e tsamaisoang e le ente e ka tlaase ea methapo e sebelisoang ka sirate e khethiloeng ka 50 mg / ml. Ho na le lipeo tse 25 mg tsa Enbrel tse fumanehang hape.
Tekanyo ea Enbrel e behiloeng bakeng sa ramane ea lefu la ramane e thehiloe boima ba ngoana. Kgetho e 'ngoe le e' ngoe ea beke le beke e teng bakeng sa bana ba boima ba lik'hilograma tse 138 kapa ho feta. Bakeng sa psoriasis ea plaque , tekanyo e tloaelehileng ke 50 mg habeli ka beke likhoeli tse tharo, e theohela hanngoe beke le beke.
Ho tšoenyeha ka ho khethehileng
Enbelle ha e kgothaletswe bakeng sa basali ba diimana kapa ba anyesang. Bakuli ba nang le tšoaetso e tebileng ha baa lokela ho tšoaroa ka Enbrel. Batho ba tloaetseng ho fumana tšoaetso kapa ba nang le lefu la tsoekere le sa laoleheng ha baa lokela ho sebelisa Enbrel. Bakuli ba nang le maemo a mang a tsamaiso ea methapo ea mantlha le bona ba lokela ho qoba Enbrel.
Liphello tse Tloaelehileng
Litla-morao tse tloaelehileng tse amanang le Enbrel li kenyeletsa:
- phetoho ea sebaka sa ente
- maloetse a phahameng a ho hema, ho akarelletsa le mafu a sinus
- hlooho ea hlooho
- botsoa
- nko ea metsi
- ho halefa ha metso
Liketso Tse Ntle Tse Ntle
Enbrel e ka eketsa kotsi ea mafu a maholo. Ho batho ba tšoaroang ka Enbrel, ho 'nile ha e-ba le litlaleho tsa multiple sclerosis , myelitis (ho ruruha ha mokokotlo oa mokokotlo), optic neuritis (ho ruruha ha methapo ea optic), le pancytopenia (manane a tlaase a lisele tse khubelu, lisele tse tšoeu, liplatelete).
Boloka
Enbrel e lokela ho bolokoa mocheso oa likhato tse 36 ho isa ho tse 46 Fahrenheit. Leha ho le joalo, Enbrel e ka bolokoa mocheso oa motšehare ka matsatsi a 14. Enbrel ha ea lokela ho bolokoa ka lehare.
Ho latela enbrel.com, haeba u tsamaea ka lihora tse 'maloa, u lokela ho koahela Enbrel ka ho phuthela' me ue behe leetong le pholileng le tletseng leqhoa. Eketsa thermometer ho pholileng 'me ue hlahlobe lihora tse seng kae tse seng kae. U ka fumana ho phomola leeto la mahala le leqhoa bakeng sa Enbrel ka ho bitsa Tšehetso ea Enbrel ka 1-888-4ENBREL. Haeba u tsamaea ka moea, hlahloba le sefofaneng sa lifofane bakeng sa litlhoko tsa bona.
Lisebelisoa:
Ramatiki e se Nang Bohloko, Scott J. Zashin, MD, E hatisitsoe ke Sarah Allison Publishing Company.
Enbrel - The Pill Book, Khatiso ea 10
Tataiso ea Meriana. Enbrel.com. E hlalositsoe 11/2013. http://pi.amgen.com/united_states/enbrel/derm/enbrel_mg.pdf
Ho hlalosa litaba. Enbrel.com. E hlalositsoe 03/2015. http://pi.amgen.com/united_states/enbrel/derm/enbrel_pi.pdf