Kemiso
Viekira Pak ke motsoako oa likokoana-hloko o sebelisetsoeng ho phekola tšoaetso e sa foleng ea lefu la sebete la hepatitis C (HCV) . Paka ena e kenyelletsa tekanyo e le 'ngoe e tsitsitseng e kopantseng lithethefatsi Technivie (ombitasvir + paritaprevir + ritonavir) e kopantsoe hammoho le dasabuvir ea lithethefatsi.
Litho tsa lithethefatsi li-ombitasvir, paritaprevir le dasabuvir li etsa li-anti-virus tse ikemetseng (DAAs) tse sitisang ho pheta-pheta ha vaerase.
Ritonavir ea lithethefatsi, e sebelisoang khafetsa ka phekolo ea HIV , e kenngoa ho matlafatsa litekanyetso tsa lithethefatsi tsa paritaprevir.
Viekira Pak ke hangata, empa eseng kamehla, e tsamaisoang ke ribavirin ebile ha e hloke ho nkoa ka pegylated interferon (peg-interferon).
Viekira Pak e ile ea amoheloa ka la 19 December, 2014 ke US Food and Drug Administration (FDA) e sebelisoang ho batho ba baholo lilemong tse 18 kapa ho feta ka likokoana-hloko tsa HCV 1, ho akarelletsa le ba nang le lefu la sebete (moo sebete se ntseng se sebetsa) le ho fetela sebete. Bakeng sa bakuli ba nang le lefu la ho ruruha ha sepakapaka, Viekira Pak ha e khothaletsoe.
Viekira Pak e boleloa hore e na le phekolo ea phekolo ea 95% kapa ho feta, e nang le 2% feela ea bakuli ba khaotsang phekolo ka lebaka la ho hloka mamello. Ho loketse ho sebelisoa ho bakuli ba nang le tšoaetsano ea HIV / HCV .
Tekanyo
Matlapa a mabeli a matlapa a entsoeng ka co-ombitasvir + paritaprevir + ritonavir (25mg / 150mg / 100mg) a nkile letsatsi le leng le le leng hoseng ka lijo, hammoho le tafole e le 'ngoe ea dasabuvir e nkiloeng habeli ka letsatsi hoseng le mantsiboea ka lijo.
Matlapa ao a tla tlala mekhoa e mengata ka letsatsi le leng le le leng, le litaelo tsa litaelo tse kenyelletsoeng lebokoseng le leng le le leng. Setlhape se entsoeng ka kopanelo ke pinki, se koahetsoeng ka filimi 'me se koahetsoe ka "AV1", ha letlapa la dasabuvir le beige, le koahetsoeng ka filimi le le nang le "AV2".
Ho hlalosa Litlhahiso
Viekira Pak e laeloa ho feta thupelo ea libeke tse 12 ho isa ho tse 24, ho ea ka litlhahiso tse latelang:
- Genotype 1a ntle le mokhoa oa ho fetela habonolo: Viekira Pak e nang le ribavirin libeke tse 12
- Genotype 1a ka ho thatafala ha sebete: Viekira pak le ribavirin libeke tse 24
- Genotype 1b ntle le ho ruruha: Viekira Pak feela ka libeke tse 12
- Genotype 1b ntle le ho ruruha: Viekira Pak e nang le ribavirin libeke tse 24
Bakeng sa ho kenyelletsa batho sebete, Viekira Pak e ka nkoa ka ribavirin libeke tse 24 feela haeba mosebetsi oa hepatic (sebete) o tloaelehile 'me fibrosis (scarring) e nyenyane.
Liphello tse Tloaelehileng
Litla-morao tse tloaelehileng tse amanang le tšebeliso ea Viekira Pak (e etsahalang ho bakuli ba ka bang 10%) ke:
- Mokhathala
- Nausea
- Letlalo le hloekileng
- Liketso tsa letlalo
- Ho tsieleha
- Bofokoli le mokhathala
Litšebelisano le lithethefatsi
Lintlha tse latelang li lokela ho qojoa ha u sebelisa Viekira Pak:
- Anticonvulsants: carbamazepine, phenytoin, phenobarbital
- Antihyperlipidemics (e sebelisetsoang ho fokotsa maemo a molumo maling): gemfibrozil
- Meriana ea anti-arrhythmia: pimozide
- Meriana e theohelang k'holeseterole: lovastatin, simvastatin
- Meriana ea ho se sebetse ka Erectile: Viagra (sildenafil)
- Meriana e nang le li-Ergot (e sebelisetsoang ho tšoara hlooho le hlooho ea migraine): ergotamine, dihydroergotamine, ergonovine, methylergonovine
- Ethinyl estradiol (mofuta o entsoeng ka motho oa estrogen)
- Meriana ea HIV : Sustiva (efavirenz) , Atripla (efavirenz + tenofovir + emtricitabine)
- Meriana ea li-hypotension: alfuzosin
- Meriana e thibelang lefuba ea Rifampin: Mycobutin, Rifater, Rifamate, Rimactane, Rifadin, Priftin
- Litloaelo: triazolam, oral midazolam
Litlhaloso le likhokahano
Bakeng sa bakuli ba nang le bokooa bo itekanetseng ba lefuba, Viekira Pak ha e khothaletsoe. Viekira Pak e hanyetsanoa bakeng sa ho sebelisoa ho bakuli ba nang le ho holofala ho matla.
Viekira Pak e boetse e hanyetsanoa bakeng sa tšebeliso ea mokuli ka mokhoa o tsebahalang oa ritonavir (ho kenyeletsa le Stevens-Johnson Syndrome, e ka 'nang ea e-ba kotsing ea bophelo,' mele eohle ea ho ruruha ha 'mele).
Viekira Pak e hanyetsanoa bakeng sa tšebeliso ea basali ba bakhachane ha e sebelisoa le ribavirin.
Ho khothalletsoa hore basali bohle ba nang le lilemo tsa bana ba behe leihlo khoeli le khoeli bakeng sa bokhachane nakong ea phekolo. Ho boetse ho kgothaletswa hore mokuli le molekane oa hae oa banna ba fanoe bonyane mekhoa e 'meli e seng ea hormone ea thibelo ea bokhachane, le hore e sebelisoe nakong ea phekolo le likhoeli tse tšeletseng ka mor'a moo.
Mohloli:
US Administration of Drug and Drug Administration (FDA). "FDA e amohela Viekira Pak ho phekola lefu la hepatitis C." Silver Spring, Maryland; tokomane ea khatiso e fanoeng ka la 19 December, 2014.