Zithromax e tšoara mefuta e mengata ea tšoaetso ea baktheria.
Zithromax ke lithibela-mafu tse fapaneng tse sebelisoang ho tšoara mefuta e mengata ea mafu a tšoaetsanoang, ho kenyelletsa le mafu a letlalo, mafu a mahlo, mafu a ho phefumoloha, le mafu a tšoaetsanoang ka thobalano. E fumaneha e le pilisi kapa ente.
Mechanism
Antibiotic Zithromax (azithromycin) e tsoa ho erythromycin, mofuta o mong oa lithibela-mafu. Le hoja ka bobeli "li-macrolides," ka tekanyo ea Zithromax ke azalide, 'me erythromycin ke khanya.
Ka mantsoe a lik'hemik'hale, Zithromax e hlalosa hantle mokhoa o tšoanang oa lactose-macrolide e le erythromycin e bolokang ho kenngoa ha nitrogen ea methylated ka lesela la lactone.
Phapang ena e fokolang ea khale e thibela baktheria ho koahela Zithromax 'me ho makatsa ho fetola mokhoa oa eona oa metabolism. Le hoja erythromycin e sebelisoa ke mokhoa oa cytochrome P450, Zithromax ha e joalo. Kahoo, Zithromax e sebelisana le lithethefatsi tse fokolang, 'me ho fapana le erythromycin, e ke ke ea sebelisana le lithethefatsi le statin (mohlala, Zocor kapa Crestor).
Joaloka li-macrolides-erythromycin le clarithromycin-Zithromax e sebetsang ka ho tlamella lik'hemik'hale tsa bacteria 50S ribosomal ka tsela ena li sitisa bokhoni ba baktheria ho hlahisa liprotheine. Libaktheria li hloka ho hlahisa liprotheine ho phela. (Ho itšetlehile ka litekanyetso, li-macrolides e ka ba bacteriostatic kapa bacteriocidal.)
Tšebetso
Tse ling tsa libaktheria tseo Zithromax li loanang ka tsona:
- Mycobacterium avium complex (MAC)
- Toxoplasmosis gondii
- Haemophilus influenza
- Streptococcus le staphylococcus (e nyenyane ho feta erythromycin)
- Helicobacter
- Moraxella catarrhalis
- Borrelia burgdorferi
- Chlamydia
Mona ke lisebelisoa tse ling tsa kliniki bakeng sa Zithromax:
- Ts'oaetso ea phefumoloho
- Letlalo le mefuta e meng ea tšoaetso e bonolo
- Lik'hemik'hale tse matla tsa baktheria tsa COPD
- Otitis media
- Pneumonia e fumanoeng ke sechaba
- Bacterial conjunctivitis (tšoaetso ea mahlo)
- Mycobacterium avium e rarahaneng kapa MAC (e leng tšoaetso ea tšoaetso e tloaelehileng e tloaelehileng le AIDS)
- Chancroid
- Pharyngitis
- Tonsillitis
- Chlamydial cervicitis le urethritis (tšoaetso ea ho kopanela liphate)
Re lokela ho hlokomela hore litekanyetso tse phahameng tsa lithibela-mafu li hanyetsa Zithromax khetho e mpe ea ho phekola mafu a mang a kang pneumonia e fumanoang ke sechaba, otitis media (tšoaetso ea tsebe) le sinusitis e matla. Ka hloko haholo, Zithromax ha e sebetse ho loantša mafu a bakoang ke MRSA, e leng tšenyo e kholo ea ho hanyetsa likokoana-hloko.
Ho itšetlehile ka tsela ea tsamaiso, Zithromax e fumaneha ka matlapa, lipalesa tsa molomo, liente le lisebelisoa tsa phekolo.
Le hoja a sa khone ho tšela thibelo ea mali-le ho tšoara meningitis, Zithromax ka ho teba e kenyelletsa mesifa ea rona. Meriana ena e boetse e lokolloa butle-butle ka mokhoa oa tsamaiso ea tsamaiso 'me e na le halofo ea bophelo ea lihora tse ka bang 48. Lintho tsena tse nang le mekhoa e metle ea pharmacokinetic li thusa lingaka hore li fane ka lithethefatsi ka nako e telele. (Halofo ea bophelo e bolela hore na ho nka nako e kae hore meriana ea mali e fokotsehe ka halofo. , halofo ea moriana o tla tlosoa maling.)
Mabapi le cervicitis le lefu la masapo le bakoang ke ho tšoaetsoa ke chlamydia, tekanyo e le 'ngoe (injection) ea Zithromax e sebetsa hantle joaloka koetliso ea matsatsi a supileng a doxycycline, kahoo, ho fokotsa meriana e sa hlokeng tlhokomelo . (CDC e khothalletsa hore baoki ba sebetsane le lefu la gonorrhea le chlamydia hammoho, e leng "phekolo" ka bobeli. Ka hona, ngaka e fana ka tlhahiso ea lefu la cephalosporin Rocephin ho phekola le ho feta.) Ka kopo hlokomela hore ho na le temoho ea ngaka ea hao kapa ho u tšoara ka Zithromycin le ka tekanyo efe. Haeba u thahasella, ka kōpo buisana ka ngaka e joalo le ngaka ea hau.
Liphello tse mpe
Le hoja e se e matla joalo ka erythromycin, Zithromycin e ka boela ea etsa hore motho a be le khatello ea kelello joaloka ho nyefoloa kapa ho hlatsa. Litla-morao tsena tse sa batleheng li ka fokotsoa ke ho ja lijo pele u nka molomo oa Zithromycin.
Lentsoe le Tsoang ho
Haeba uena kapa motho eo u mo ratang a e-na le lefu la pelo, e ka 'na ea e-ba maikutlo a matle ho qoba Zithromycin. Meriana ena e tsejoa ho baka QT-prolongation, arrhythmia, le lefu la tšohanyetso. Ka hloko, QT-prolongation e kena-kenana le lipina tsa mahlo.
Ntho e ntle ka Zithromycin ke hore halofo ea nako e telele le menyetla e seng mekae e fokotsa ho se tsotelle. Ka mohlala, tekanyo e le 'ngoe ea lithethefatsi ena e nkiloeng ofising ea ngaka ke phekolo e feletseng; athe, haeba u tlameha ho nka doxycycline u le beke, u ka lebala kapa ua khaotsa.
Leha ho le joalo, ha ho boleloa Zithromycin bakeng sa tšoaetso ea mafu a tšoaetso, tšoaetso ea 'metso le joalo, ho hlokahala hore re bone phekolo. Ha re hlōleha ho phekola phekolo le likokoana-hloko tse bolaeang ka ho feletseng 'meleng oa rona, libaktheria tse hanyetsang li pholoha' me li jala-ho tšoaetsa ba bang, ho tsosolosa, le ho hanyetsa libaktheria tse ling.
Ka kopo hopola hore ka ho tlohela kalafo ea lithibela-mafu, re kenya letsoho ho thibela lithibela-mafu, e leng bothata ba lefats'e. Ntoa ea ho loantša lithibela-mafu ke e 'ngoe ea likheo tse tsoelang pele le ho phalla,' me boholo ba lihlomo tsa rona tsa pele tsa bongaka bo hlatsoitsoe. Re lokela ho etsa sohle se matleng a rona ho loantša lithibela-mafu.
> Mohloli
> Deck DH, Winston LG. Khaolo ea 44. Tetracyclines, Macrolides, Clindamycin, Chloramphenicol, Streptogramins, & Oxazolidinones. Ka: Katzung BG, Masters SB, Trevor AJ. eds. Melemo & Meriana ea Boipheliso ea Meriana, 12e . New York, NY: Hill ea McGraw; 2012.
> Mosby's Drug Reference bakeng sa Bophelo bo Botle, Khatiso ea Bobeli e hatisitsoeng ke Elsevier ka 2010.
> O'Donnell MR, Saukkonen JJ. Khaolo ea 168. Mantsoe a Antimycobacterial. Ka: Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson J, Loscalzo J. eds. Melao-motheo ea Harrison ea Internal Medicine, 18e . New York, NY: Hill ea McGraw; 2012.