L-lisele ke karoloana ea lisele tse tšoeu tsa mali tse nang le karolo ea bohlokoa methong ea 'mele ea ho itšireletsa mafung le ho loantša kankere. A re fokolise tsamaiso ea 'mele ea ho itšireletsa mafung e be likarolo ho etsa hore ho be bonolo ho utloisisa.
Ho na le mefuta e 2 e ka sehloohong ea lisele tse tšoeu tsa mali (leukocyte): lymphocytes le granulocyte.
Lymphocyte, ka lehlakoreng le leng, e senyehile ho kena:
- Lisele tsa T (lisele tse fumanoang ke thymus)
- Lisele tsa B ( lisele tsa motsoako oa bone)
Mofuta oa ts'oaetso
Mele ea rona e na le mefuta e 2 ea mantlha ea ho itšireletsa mafung :
- Ho itšireletsa mafung
- Ho itšireletsa mafung
Lisele tsa T ke karolo ea ho itšireletsa mafung ea 'mele, karolo ea sesole sa' mele sa ho itšireletsa mafung seo u ka se bonang ka ho toba ho bolaea libaktheria, livaerase le lisele tsa kankere. Mofuta o mong oa ho itšireletsa mafung-o sireletsa 'mele ea rona ho bahlaseli bana ka ho etsa li-antibodies.
Mefuta ea li-T cell
Ho na le mefuta e 'maloa ea lisele tsa T, tse kenyeletsang tse latelang:
- Lisele tsa T-littoxicone - Lisele tsa T-sotophilia li fumana le ho hlasela ka ho toba basele ba kang libaktheria, likokoana-hloko le lisele tsa kankere.
- Lisele tsa mothusi oa T - Lisele tsa Helper T li sebelisa lisele tse ling tsa 'mele tsa ho itšireletsa mafung' me li hlophisa likarabo tsa 'mele oa ho itšireletsa mafung
- Lisele tsa T tsa tsamaiso - Likhoeli tsa T tse laoloang li nahanngoa hore li lokela ho thibela tsamaiso ea 'mele ea ho itšireletsa mafung e le hore e se ke ea feteletsa (joalokaha e etsa ka maloetse a mangata), leha ho le joalo likarolo tse bohareng tsa bielo tsa lisele tsena li ntse li tsejoa ke sephiri' me li tsoela pele ho phehisana khang haholo.
- Lisele tsa T tsa tlhaho - Lisebelisoa tsa tlhaho T (NKT) ha li tšoane le lisele tse bolaeang tsa tlhaho, empa li na le tse ling. Lisele tsa NKT ke lisele tsa T-cytotoxic tse hlokang ho etsoa pele le ho khetholla ho etsa mosebetsi oa tsona. Sesea sa tlhaho (NK) lisele le lisele tsa NKT ke li-lymphocyte tse nang le karolo e tloaelehileng. Bobeli ba ka potlakela ho arabela ka ho ba teng ha lisele tse hlahisang likokoana-hloko 'me ba kenella mecheng ea ho itšireletsa mafung e khahlanong le' mele.
- Lisele tsa Memory T - Lisele tsa Memory T li hopola likarolo holim'a libaktheria, likokoana-hloko kapa lisele tsa kankere tseo ba li boneng pejana.
Ho hlahisa, ho boloka le ho fumaneha
Ka mor'a hore li hlahisoe lerung la masapo , lisele tsa T li qeta nako e itseng li ntse li hōla 'me li hlahisa litho tsa sefubeng se bitsoang thymus-ke ka lebaka leo li bitsoang mabitso a T, a emelang lisele tse fumanoang ke thymus. Kamora 'meleng oa limela, lisele tsa T li teng maling le lymph nodes .
Mosebetsi oa T-Cell Kankere
Lisele tsa T li phetha karolo e kholo ntoeng ea rona khahlanong le kankere. Ho ka ba ho ferekanngoa haholo ho bua ka lisele tsa T, haholo-holo ha re bua ka kankere e kang lymphoma, kahoo re tla sheba litsela tseo lisele tsa T li sebetsang ho loantša kankere le hore na li ka 'na tsa angoa ke kankere joang. Ho felisa kankere, esita le haeba ho na le lisele tse ngata tsa T, li qala ho "bona" kankere.
Litsela tseo ka tsona li-cell tsa T li sebetsang ho loantša kankere
Lisele tsa T li sebetsa ka litsela tse peli tse tobileng le tse sa tobang ho loantša kankere.
- Lisele tse bolaeang T li bolaea lisele tsa kankere ka ho toba - Lisele tsena li qala ho fumana lisele tsa kankere ebile li ka susumelletseha ho bolaea lisele tsa kankere.
- Lisele tsa mothusi oa T li loantša kankere ka tsela e sa tobang - Lisele tsena li hlophisa le ho hlophisa ho loantša kankere.
Litsela tseo ka tsona li-cell tsa T li amehang ka kankere
- Ho kenella ka kotloloho kankere - Ka kankere e kang T-cell lymphoma , lisele tsa T li na le kankere.
- Bone marrow takeover - Lymphomas le likarolo tse ling tsa kankere tse jalang lerung la masapo li hlahisa lisele tse nang le bophelo bo botle mongobo (li-precursor tsa lisele tsa T) tse felisoang ke ho felisoa ha lisele tsa T.
- Tšenyo e bakoang ke chemotherapy - Chemotherapy e ka felisa ka ho toba lisele le lisele tse ling tse tšoeu tsa mali.
Immunotherapy
Phuputso e entsoeng morao tjena ea lipatlisiso e akarelletsa ho tsosolosa li-T tsa lisele tsa mokuli e le hore li ka tseba le ho bolaea lisele tsa kankere. Mokhoa ona oa phekolo o bontšitse liphello tse tšepisang pele ho lymphoma.
Ketsahalo ea Kankere ea ho itšireletsa mafung
Lisele tsa T li karolo ea se tsejoang e le sekolo sa ho itšireletsa ka kankere.
Ha lisele tsa kankere li shoa, li lokolla likokoana-hloko, lisebelisoa tse ka tsejoang ke sesole sa 'mele.
Li-antigen tsa lisele tsa kankere li fetisoa ebe li hlahisoa ka seleng ea lisele tse khethehileng tsa 'mele tse bitsoang antigen-presenting cells (APCs) e le hore lisele tse ling tsa' mele li "bone" likokoana-hloko tse thahasellisang. Li-lymph nodes, APCs li sebelisa lisele tsa T 'me li ba ruta ho lemoha lisele tsa hlahala. Lisele tsa T lia tsamaea ka methapo ea mali ho fihla hlahala, ho kenella ka eona, ho hlokomela lisele tsa kankere le ho li bolaea.
> Mehloli:
> Mokhatlo oa Kankere oa Amerika. Ke eng e ncha Kankere ea Immunotherapy Research? 11/05/15.
> Chen, D., le I. Mellman. Oncology e Kopana le Immunology: K'homphieutheng ea Ts'oaetso ea Kotsi. Ho itšireletsa mafung . 2013. 39 (1): 1-10,25.
> Chen, D., Irving, B., le F. Hodi. Mekhoa ea likokoana-hloko: Moloko o latelang oa Immunotherapy - Ho thibela ho loantša lefu-Ligand 1 le ho lokisoa lefu-1. Phuputso ea Kankere ea Bongaka . 2012. Etsa: 10.1158 / 1078-0432.CCR-12-1362.