Lipontšo, Melemo le liphello tsa mahlakoreng tsa Phekolo
Phosphodiesterase-4-inhibitors (PDE4) e kang Daliresp (roflumilast) ke mofuta o mocha oa lithethefatsi bakeng sa lefu la chronic obstructive pulmonary (COPD ) le mafu a mang a matšoafo. Lithethefatsi tsena li sebetsa ho thibela ho ruruha litseleng tsa moea bakeng sa batho ba hanyetsanang le phekolo e tloaelehileng. Daliresp (roflumilast) ke eona feela PDE4 inhibitor e amohelehang hona joale United States.
Kamoo Phosphodiesterase-4-Inhibitor e sebetsang kateng
Meriana e kang mosebetsi oa Dalirespection ka ho thibela liphello tsa phosphodiesterase 4, e leng enzyme e sebetsang ho senya molek'hule e bitsoang cyclic adenosine monophosphate (cAMP.) Ho eketseha ha moruoa (hobane ha ho robehe ke phosphodiesterase 4) ho etsa ho fokotsa ho ruruha matšoafo har'a lintho tse ling.
Pontšo ea COPD ke ho ruruha ho sa foleng, 'me batho ba nang le COPD le asthma ba atisa ho ba le palo e ngata ea PDE4 e tlatsetsang ho ho ruruha hona.
Ka ho ruruha ho fokolang, meriana e kang Daliresp e ka fokotsa lik'hamphani tse ngata tsa COPD, le ho fokotseha ho lokisoa ha sefofane.
Li-Inhibitors tsa PDE4 li etsa'ng?
Ka ho eketsa litekanyetso tsa CAMP le ho fokotsa ho ruruha, li-inhibitor tsa PDE4 li ka fokotsa palo ea boima ba COPD le ho ntlafatsa mosebetsi oa matšoafo. Ka katleho ea kopano, li ka boela tsa baka marohano a mangata.
Ho bohlokoa ho hlokomela hore lithethefatsi tsena ha li lokisa matšoafo, li sebetsa ho fokotsa ho ruruha le ho thibela tšenyo e eketsehileng le ho fokotsa matšoao.
Maemo ao Daliresp (Roflumilast) a ka e sebelisang
Maemo ao Daliresp e ka sebelisoang ho kenyelletsa:
- COPD
- Pherekano
- Psoriasis
- Matšoao a mafu a Psoriatic
Li Sebelisoa Neng?
PDE4 inhibitors tse kang Daliresp li sebelisetsoa ho ntlafatsa mosebetsi oa matšoafo ho batho ba nang le COPD ba tsitsitseng ba sa hanyetsanang le phekolo e tloaelehileng.
Le COPD e bonahala e le molemo haholo ho batho ba nang le bronchitis e sa foleng ba nang le makhetlo a mangata a ho kula ha bona .
Kaha lithethefatsi tsena li sebetsa ka ho ruruha ho sa foleng, ha li sebelisetsoe ho hlaseloa ka matla ho COPD kapa asthma, empa ho e-na le hore e hlokomele e sa foleng ea lefu lena.
Ho fapana le li-bronchodilator tse khotsofalitsoeng, Daliresp ke meriana ea letsatsi le leng le le leng, ea moriana e fumanoeng ho ntlafatsa maphelo a bakuli ba tšoaroang ka salmeterol le Spiriva (tiotropium.)
Phello ea PDE4 inhibitors e bonahala e le e eketsang le corticosteroids.
Litla-morao
Litla-morao tse kholo tsa li-inhibitor tsa PDE4 li kenyelletsa letšollo, ho nyefoloa ke pelo, le hlooho ea hlooho. E ka baka boima ba 'mele, kahoo boima bo lokela ho hlahlojoa nakong ea phekolo' me bo bakile matšoao a kelello ho batho ba bang.
Likamano
Ka lebaka la metabolism ea eona ka cytochrome P-450, PDE4 inhibitors e ka kena-kenana (ho eketsa kapa ho fokotseha) meriana e meng e boetse e sebelisoa ka tsela ena, mohlala, meriana e kang erythromycin, cimetidine, lipilisi tsa thibelo ea bokhachane, meriana e meng ea ho noa, le ho feta.
E boetse e tsejoa e le: PDE4, e khethollang phosphodiesterase-4 inhibitors
Lisebelisoa:
Ferguson, G., le B. Etsa. Tsamaiso ea maloetse a sa foleng a li-pulmonary disease. E maemong. E fetotsoe 01/21/16.
Mulhall, A., Droege, C., Ernst, N., Panos, R., le M. Zafar. Phosphodiesterase 4 inhibitors bakeng sa phekolo ea mafu a sa foleng a ho folisa lefu: tlhahlobo ea lithethefatsi tsa morao-rao le tse ntseng li ntlafatsa. Maikutlo a Litsebi mabapi le Lithethefatsi Tsa Investigational . 2015. 24 (12): 1597-611.
Reid, D., le N. Pham. Roflumilast: phekolo e ncha bakeng sa boloetse bo sa foleng ba pulmonary pulmonary. Annals ea Pharmacotherapy. 2012. 46 (4): 521-9.
Laebrari ea Sechaba ea Meriana ea US. MedlinePlus. Roflumilast. E ntlafalitsoe ho 08/15/12. https://www.nlm.nih.gov/medlineplus/druginfo/meds/a611034.html