Lipoprotein (a), eo hape e tsejoang e le Lp (a), ke e tlase-palo ea lipoprotein (LDL, kapa "cholesterol" e mpe) e nang le mofuta o mong oa protheine, e bitsoang glycoprotein, e tlamellana le eona. (Lebitso la glycoprotein ena ke apolipoprotein (a). )
Bafuputsi ba ntse ba sebetsa ho utloisisa lipoprotein (a) le litsela tseo li ka amang bophelo ba hau ka tsona. Leha ho le joalo, liphuputso tse ling li bontša hore ho ba le lipoprotein tse phahameng (a) ho potoloha maling a hao ho ka u beha kotsing e kholo ea ho hlaolela lefu la pelo .
Seo Lipoprotein (a) E se etsang
E entsoe sebeteng mme o kena madi a hao, lipoprotein (a) e bontsitsoe hore e hahe ka tlas'a lera la ka hare la methapo. Mokhoa ona o ka tlatsetsa ho nts'ets'etsong ea atherosclerosis-boitsebiso ba mafura a methapong ea hao e ka lebisang ho lefu la pelo, lefu la pelo le ho otloa ke lefu-ka ho khothalletsa ho ruruha ha motsoako (bofubelu le ho ruruha) le ho thehoa ha lisele tsa mafura, lisele tse mafura tse amanang le atherosclerotic plaques Holim'a moo:
- Lipalo tse phahameng tsa lipoprotein (a) li lumeloa hore li kotsi ka ho fetisisa ho marako a maholo ha boemo ba motho ba LDL ("bad") k'holeseterole e boetse e phahame.
- Lipalo tse phahameng tsa lipoprotein (a) li bontšitsoe ho fokotsa menyetla ea ho phela ho motho ea nang le lefu la pelo.
Maemo a tloaelehileng
Lipatlisiso tsa tlhahlobo ea mali bakeng sa litekanyetso tsa lipoprotein (a) li hlahisoa ka limiligrama ka deciliter (mg / dL). Lebelo la 30 mg / dL le nkoa le tloaelehile. Liphuputso tse phahameng ho feta 30 mg / dL li ka 'na tsa bontša kotsi ea lefu la pelo ea 2 ho isa ho 3.
Leha ho le joalo, lipoprotein (a) litekanyetso ha li karolo ea tlhahlobo ea mali ea lenane la mali, e leng litekanyo tsa k'holeseterole eohle , LDL le k'holeseterole ea HDL le triglycerides (mofuta oa mafura o fumanoang 'meleng oohle). Ke hobane 1) ha hoa lekana ho tsejoa ka lipoprotein (a) phello ea bophelo bo botle ba pelo le 2) e fumanoa feela ka 15 lekholong ea baahi ba bangata, le batho bao e seng batho ba se nang Sepanishe ba Caucasian, ba Sechaena le ba Japane ba nang le boemong bo tlaase ka ho fetisisa maemo.
Seo se boletse hore ho na le maemo a fokolang moo ho ka bang molemo ho hlahloba lipoprotein (a) maemong a mangata. Haholo-holo, tsena ke ha motho a na le:
- Boloetse ba lefu la pelo le maemo a tloaelehileng a HDL, LDL, le triglycerides
- Histori e matla ea lelapa la lefu la pelo empa, hape, e tloaelehileng ea HDL, LDL le maemong a triglyceride
- Ho tsoela pele ka litekanyetso tse phahameng tsa LDL ho sa tsotellehe ho tšoaroa ka mabifi
Na U Lokela ho Leka ho Fokotsa Litsela Tsa Hao?
Ka bomalimabe, hobane lipoprotein (a) litekanyetso li susumetsoa haholo ke liphatsa tsa lefutso tsa hau, litlhahiso tse tloaelehileng-phepo e nepahetseng, ho ikoetlisa kamehla, le (boholo) k'holeseterole-ho theola meriana- ha e na phello e kholo ea ho e theola. Niacin e bontšitse tšepiso e itseng litulong tsa bongaka bakeng sa ho theola lipoprotein (a) maemo. Leha ho le joalo, ha e sebelisoe kamehla bakeng sa morero oo.
Haeba o leka ho fokotsa kotsi ea ho ba le lefu la pelo, ho molemo ho beha lipoprotein (a) kalafo ea "morao" bakeng sa hona joale le ho tsepamisa kelello ka mekhoa ea ho fokotsa lits'ebotsi tse nang le kotsi tsa lefu la pelo. Joalokaha mohlomong u tseba, tsena li kenyeletsa ho fokotsa khatello ea mali haeba e phahame haholo, ho theola k'holeseterole e phahameng ea LDL le ho phahamisa k'holeseterole e tlaase ea HDL. Liphuputso tse ngata li bontšitse hore ho lebisa tlhokomelo ho likotsi tsena ho ka thusa ho fokotsa kotsi ea ho ba le lefu la pelo kapa leqeba.
Lisebelisoa:
Erquo S, Kaptoge S, Perry PL et al. Lipoprotein (a) ho imeloa kelellong le kotsi ea lefu la pelo, lefu la pelo, le lefu la se seng sa tlhaho. JAMA 2009; 302: 412-423.
Boffa MB, Koschinsky ML, Berglund L. Lipoprotein (a): e ikhethang ea kotsi ea lefu la pelo. Clin Lab Med 2006; 26: 751-772.
"Tlhahlobo ea teko: LIPA-lipoprotein (a) serum." Sepetlele sa Mayo-Mayo Medical Laboratories (2016).
Kang S. "Ke lipoprotein (a) eng mme e bolela'ng ho uena?" HealthCentral (2008).