Li-biomaterials li fetoha karolo ea bohlokoa ea mekhoa e mengata ea kalafo le ea ho hlahloba, 'me lipatlisiso tšimong ena li ntse li hōla ka potlako. Tse ling tsa libaka tse thabisang ka ho fetisisa ke mafu a meriana , mafu a liphate , phekolo ea kankere le tlhokomelo ea meno.
Ho na le lintho tse ngata tse entsoeng ka morero oa ho nka mokhoa o sebelisoang ho tsamaisa mokhoa oa phekolo kapa oa ho hlahloba .
Le hoja liphuputso tse ngata ka li-biomaterials li etsoa ka mehlala ea liphoofolo kapa ka-vitro hona joale, bo-rasaense ba bolela esale pele hore liphuputso li tla tloha li sebelisoa litsing tsa batho.
Li-ophthalmology le BioMaterials
Letlalo la amniotic (AM) le 'nile la sebelisoa ho buuoa ha leihlo ka lilemo tse ngata. Morao tjena, ho 'nile ha etsoa litsela tse ncha tsa hore sebaka sa cornea se sebetse hantle. Hangata opereishene ena e etsoa ha ho e-na le kotsi e sa feleng ho leihlo le bakoang ke boloetse kapa lik'hemik'hale tse chesang.
AM e fumanoa ho tloha ka hare-hare ea placenta 'me e na le lisebelisoa tse khahlanong le ho ruruha le tse hanyetsang, tse etsang hore e be sekhechana se setle. Leha ho le joalo, lisele tsa AM li na le 'mele o fokolang le o fokolang, o ka amang pono ea motho. Hona joale bo-rasaense ba ntse ba etsa lipatlisiso tsa litsela tsa ho hlasela le ho hlalosa ka ho hlaka AM ka ho theha lesela la maiketsetso. Ba lumela hore seo ba se fumaneng se tla thusa AM esale pele ka litsela tse molemo ho sebelisang boitsebiso boo ka ho buuoa ka leihlong la leihlo la motho.
Li-Biomaterials bakeng sa Tlhahlobo ea Kankere e Ntlafetseng le Phekolo
Hape ho bile le tsoelo-pele e ngata ho sebelisa li-biomaterial tse fapaneng ho phekola kankere. Tsena li kenyelletsa ho sebelisa lisebelisoa tsa pele ho fumana hore na lefu lena le fapane joang, le ho li sebelisa ho fana ka lithethefatsi tse khahlanong le kankere ka mokhoa o atlehileng.
Meriana e sebetsanang le lithethefatsi ka ho toba e nkoa e le mokhoa o khethehileng oa ho phekola kankere. Ba khona ho hlahisa litsietsi tse kholo ho lisele tsa kankere le ho baka liphello tse seng kae.
Bakeng sa phekolo ea kankere ea sebakeng seo, bafuputsi ba Univesithing ea Adelaide, Australia, ba etselitse le ho etsa lisebelisuoa tsa motlakase tsa 3D titanium ka titania nanotube arrays tse ka mamelloang ke lithethefatsi tsa kankere le ho sebetsa e le lisebelisoa tsa ho fana ka lithethefatsi. Liphuputso tsa bona li bontšitse hore ha kankere ea kankere e fanoa ka li-implants tse ncha, lisele tsa kankere ea matsoele li ile tsa sitoa ho phela. Nakong ea lipatlisiso tsa bona, matsatsi a mararo ka mor'a ho kenngoa ha sethala, lisele tsa 'mele li qala ho khutla. Bafuputsi ba boetse ba totobatsa hore mokhoa ona o mocha oa chemotherapeutic o ka fetisetsoa ho mefuta e meng ea kankere nakong e tlang.
Ho fana ka lithethefatsi setsing se tobileng sa leqeba ke mokhoa o ntseng o lekoa libakeng tse ling tsa meriana. Ka mohlala, likokoana-hloko tse hanyetsanang le lithethefatsi, tse fetohileng bothata bo ntseng bo eketseha ka lebaka la ho sebelisa lithibela-mafu tse ngata, li ka phekoloa li sebelisa tsoelo-pele ea morao-rao libakeng tsa tlhaho. Likoloi tsa silika tse nang le methapo ea silevera e sebelisitsoeng ka silevera e se e sebelisitsoe mefuteng ea litoeba ho fana ka lithibela-mafu ho ea libakeng tsa tšoaetso e sa thibeleng.
Lipatlisisong tsa liphoofolo, nanoplatforms li bontšitsoe hore li sebetsa hantle ho bolaea libaktheria, ka nako e le 'ngoe li sebelisa lichelete tsa silevera le lithibela-mafu.
Cartilage Tissue Engineering
Dr. Tanya Levingstone oa Royal College of Surgeons Ireland (RCSI) o ntse a hlahloba sebaka se seng se thabisang sa lipatlisiso tsa likokoana-hloko. Levingstone ke karolo ea Bone le Tissue Engineering Research Group. Sehlopha sena se entse tsoelo-pele e kholo tabeng ea ho theha boitsebiso bo ka thusang ho tsosolosa manonyeletso a senyehileng. Sehlopha se entsoeng lipatlisiso se ile sa ikopanya le setsi sa lipatlisiso AMBER ( Lisebelisoa tse Phahameng le Liphuputso tsa BioEngineering) 'me sa ntshetsa pele sefate sa 3D se nang le mafura a mangata a nang le collagen, hydroxyapatite le hyaluronic acid.
Lintho tsena kaofela li teng ka motsoako o phetseng hantle 'me li na le bokhoni ba ho tsamaisa lisele tsa' mele ho lokisa manonyeletso a senyehileng.
Liphuputsong tsa bona tsa morao-rao, bafuputsi ba Maaerishe ba ile ba leka tlhahlobo eo ka likhoeli tse 15 tse hlalositsoeng ka ho feletseng. Pere e ne e tšoeroe ke mafu a senyehang a mabeli a hae a mangole a tsejoang e le li-dissecans tsa osteochondritis. Maemong a mang a boemo bona a ka ba matla haholo liphoofolong tseo a lokelang ho li khothaletsa. Ka mor'a ho etsa mekhoa e tloaelehileng ea tlhaho e ileng ea tlosa likarolo tse sa tsitsang tsa mangole, li-scaffolds tse ngata tse khabisitsoeng li ne li kenngoa liputsong tsa pere. Ka lebaka leo, bone le masapo a macha a ile a thehoa, joalokaha ho bontšitsoe phuputsong ea likhoeli tse hlano ka mor'a hore ho etsoe mokhoa oa pele. Pere e nyenyane e nang le tebello e bohloko e fetileng e khutlela thupelong ea liketsahalo tsa jumping.
Litaba tsena li 'nile tsa e-ba le patente' me hona joale li tsejoa e le ChondroColl. Ke sehlahisoa sa bobeli sa sehlopha ts'ebetsong ea ho tsosolosoa ha masapo. Nakong e fetileng, ba ile ba etsa liteko le ho leka tlhahlobo ea lesapo le bitsoang HydoxyCall, e seng e amohelehile CE mme e tlisitsoe 'marakeng ke khampani ea qala ho tloha RCSI, e bitsoang SugarColl Technologies. Kajeno ChondroColl e letetse tumello ea molao, 'me lithuto tsa pele ho batho ba nang le bokooa ba osteochondral li lebelloa hore li qale nakong e tlang.
Ho Thibela Phoso ea Mino
Bafuputsi ba Univesithing ea Pennsylvania ba shebile litsela tse molemo tsa ho tlosa letlapa la meno le ka 'nang la etsa hore ho qaleha ha leino ho bola. Ba ile ba etsa li-nanoparticles tse nang le liketsahalo tse kang peroxide tse ka senyang matrix a sireletsang a potolohileng libaktheria tse fumanoang melomong ea hau. Mokhoa ona oa libuka o se o ntse o lekoa litekong tsa litoeba 'me o bontšitse ho fokotseha ho hoholo ha ho senyeha ha leino. Sehlopha se tšepa hore haufinyane se tla sebelisa tsebo ena ho phekola mafu a molomo. Ba etsa tlhahiso ea ho kenyeletsa li-nanoparticles tse nang le li-peroxide lihlahantsoeng tsa menoang tsa khoebo le lihlahisoa tsa mouthwash e le leano le lecha la ho loantša leino.
Lisebelisoa:
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Hariya T, Tanaka Y, Yokokura S, Nakazawa T. Phaliso, mochine o tsitsitseng oa amniotic o hlahisa limela tse kenyang metsi. Li-biomaterials, [marang-rang a inthaneteng]. September 12016; 101: 76-85.
Kaur G, Willsmore T, Evdokiou A, et al. Li-implants tsa tšepe tsa Titanium tse nang le nanotube arrays: Mohlala oa ho ithuta oa phekolo ea kankere ea sebakeng seo. Li-biomaterials [mochine oa inthanete]. La 1 September, 2016; 101: 176-188.
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Tšepe J, Levingstone T, David F, et al. Ho lokisoa ha osteochondritis e khōlō ho qoba liso le sebelisa mohaho o mongata oa lihlahisoa tse ngata tse entsoeng ka mahlaseli ho moatlelete oa equine. Litaba tsa Tissue Engineering le Meriana ea Boikhathollo [ea marang-rang]. La 20 May, 2016; E fumaneha ho tloha MEDLINE, Ipswich, MA. E fihlile ka la 11 June, 2016.
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