TSH ke Tlhahlobo ea Bohlokoa bakeng sa ho Khetholla le ho Lebela Mosebetsi oa Thyroid
Ho fetolela li-TSH ha ho hlile ha ho bonolo, kahoo ha u mong ha u ntse u ipotsa hore na likhaolo tsa thyroid tsa hao li bolela'ng , 'me ka ho khetheha litekanyetso tse phahameng le tse tlaase tsa TSH li bolela phekolo.
Ka mohlala, u ka 'na ua ipotsa hore na ke hobane'ng ha ngaka ea hau e batla ho fokotsa ho e-na le ho phahamisa meriana ea hau ea qoqotho ha liphello tsa hau tsa TSH li le tlase, kapa, ka lehlakoreng le leng, ke hobane'ng ha ngaka ea hao e eketsa meriana ea thyroid ha TSH ea hao e phahame.
Kholiseha, hore le hoja ho ka bonahala eka ka morao, ke ntho e utloahalang ha u sheba biology ea tlhahiso ea lihomone tsa thyroid.
Li-basics tsa Thyroid
Thyroid thyroid e hlahisa hormone ea thyroid. Ha e sebetsa ka mokhoa o nepahetseng, thyroid ea hao ke karolo ea likarabo tsa maikutlo le pente ea hau ea pituitary e akarelletsang mehato e 'maloa ea bohlokoa:
- Ntlha ea pele, pituitary ea hao e utloa boemo ba hormone ea qoqotho e lokollang mali.
- Pituitary ea hau e hlahisa hormone e khethehileng ea mongoli: thyroid e susumetsang hormone (TSH). Karolo ea TSH ke ho susumetsa qoqotho hore e lokolle lihomone tse ngata tsa qoqotho.
- Ha thyroid ea hao, ka lebaka leha e le efe-bokuli, khatello ea kelello, ho buuoa kapa ho thibela, ka mohlala-ha e khone ho hlahisa hormone ea qoqotho e lekaneng, pituitary ea hau e fumana mefuta e fokotsehileng ea hormone ea qoqotho 'me e fetela liketsong ka ho eketsa TSH, e ntan'o susumelletsa qoqotho ea hao ho etsa hormone e ngata ea qoqotho. Ena ke boiteko ba pituitary ea ho phahamisa likarolo tsa hormone ea qoqotho le ho khutlisetsa mokhoa ona o tloaelehileng.
- Haeba thyroid ea hao e feteletse 'me e hlahisa hormone ea qoqotho e ngata-ka lebaka la maloetse, kapa ho noa meriana e mengata ea qoqotho ea li-hormone-e leng lisosa tsa hau tsa pituitary tse nang le hormone e ngata ea qoqotho e potolohang le e liehang kapa e thibela tlhahiso ea TSH. Ho theoha ho TSH ke boiteko ba ho khutlela ho potoloha li-hormone tsa thyroid ho tloaelehileng.
Ho hlalosa likhaolo tsa TSH
Hang ha u utloisisa lithuto tsena tsa qoqotho, ho bonolo ho utloisisa hore na TSH e tlase le TSH e phahameng e senola eng ka mosebetsi oa thyroid.
Ho tloha ha TSH e phahamisa li-hormone tsa qoqotho 'me e boloka tsamaiso ena e lekana hantle:
- TSH e phahameng e fana ka maikutlo a hore thyroid ea hao e sa sebetse (hypothyroid) ebile ha e etse mosebetsi oa eona oa ho hlahisa hormone ea qoqotho e lekaneng. TSH e feteletseng e sebetsa ho matlafatsa thyroid ea hau ho hlahisa hormone e ngata ea thyroid.
- TSH e tlaase e bontša hore thyroid ea hao e feteletse (hyperthyroid) mme e hlahisa hormone e ngata ea qoqotho. Lefu la pituitary le hatella TSH e le hore qoqotho e se ke ea hlahisa le ho feta.
Na TSH e Tšepahala?
Nakong ea ho hlahlojoa, lingaka tse ngata li sebelisa teko ea TSH ho hlahloba sebopeho sa thyroid le ho fumana tsela e nepahetseng ea phekolo.
Leha ho le joalo, hlokomela hore lingaka tse ling li nahana hore ho itšetleha feela ka TSH, ntle le ho hlahloba litekanyetso tsa li-hormone tsa qoqotho, tse kang thyroxine (T4) ea mahala, e ka 'na ea se ke ea khona ho lemoha mathata a mangata a qoqotho a qoqotho.
Ka mohlala, mahala T4 ho phaella ho TSH hape e lekoa haeba ngaka e belaella ho se sebetse ha qoqotho e bakoang ke mafu a planditary gland kapa hypothalamus. Ka ho tšoanang, haeba TSH e tloaelehile, empa motho a ntse a e-na le matšoao a ho ba hyperthyroid kapa hypothyroid, T4 ea mahala e ka hlahlojoa.
TSH hape ha e lekane ho boloka hypothyroidism nakong ea bokhachane , ke ka lebaka leo mahala T4 le / kapa kakaretso ea T4 le tsona li hlahlojoang.
Ho itšetlehile ka boemo ba bongaka, liteko tse ling tsa qoqotho tse ka hlahlojoang li akarelletsa triiodothyronine (T3), T3 e tsosolosang le liteko tsa antibody.
Lintlha tsa Boitsebiso ba TSH
Tlhōrō e kholo e amanang le TSH ho hypothyroidism le hyperthyroidism ke ho se lumellane ho tsoelang pele lefatšeng la bongaka ka lebaka la lethathamo la lipatlisiso bakeng sa teko ea TSH.
Litekanyo tse ka tlase ho 0,4 li nkoa e le bopaki bo ka khonehang ba hyperthyroidism, 'me maemo a ka holimo ho 5.0 a atisa ho nkoa e le bopaki bo ka khonehang ba hypothyroidism, empa litsebi tse ling li nahana hore lebelo lena le leholo haholo le hore le lokela ho fokotsoa ho 0,4 ho 2,5mU / L.
Ho Etsa Lits'oaetso tse thehiloeng ho TSH
Ha o ntse o phekoloa bakeng sa hypothyroidism le lithethefatsi tse ling tsa qoqotho tse ling tsa thyroid, hangata lingaka li leka ho u phekola ka lehlakoreng le tloaelehileng la TSH ho tloha ho 0.3 / 0.5 ho ea qetellong, ho ea ho 3.0 / 5.0 ho ea qetellong.
Kahoo, ha o e-ea ho hlahloba 'me TSH ea hau e kenella ka tlase e tloaelehileng (e bolelang hore TSH e hatelloa hobane litekanyetso tsa qoqotho li se li le phahameng), ngaka ea hao e ka' na ea batla ho fokotsa tekanyo ea hau ea hormone ea qoqotho hobane u se u ntse u le hyperthyroid . Lebaka ke hore ho tlosoa ho feteletseng ha TSH (e bolelang ho hlahisa chai ea lihomone tsa qoqotho) ho ka eketsa kotsi ea motho ea ho fokotsa lefu la 'mala (pelo arrhythmia) kapa osteoporosis.
'Me haeba teko ea hau ea TSH e feta ka tsela e tloaelehileng, lingaka tse ling li tla batla ho eketsa litekanyetso tsa hau tsa hormone ea thyroid, hobane litekanyetso tse ka holimo ho tloaelehileng li nkoa e ka ba hypothyroid (e sa sebetse).
Lentsoe le Tsoang ho
Ka kakaretso, tlhahlobo ea TSH ke lingaka tsa teko ea mali haholo-holo li sebelisang ho hlahloba hypothyroidism le hyperthyroidism le ho hlahloba thyroid ea phetoho ea phekolo (haeba ho hlokahala).
Le hoja maemo a tsa bongaka, joaloka ho ima kapa ho kenngoa sepetlele, a ka 'na a hloka hore T4 le T3 li lekanyetsoe, ho utloisisa moelelo oa motheo oa litekanyetso tse phahameng kapa tse tlase tsa TSH tse bolelang hore motsoako oa hau oa qoqotho ke oa nama ea seo u lokelang ho se tseba.
Seo se boletse, haeba u na le lipotso mabapi le mosebetsi oa mali oa thyroid o amanang le thyroid, etsa bonnete ba hore o botsa ngaka ea hau.
> Mehloli:
> Bahn, R., Burch, H, Cooper, D, le al. Hyperthyroidism le Mabaka a mang a Thyrotoxicosis: Tataiso ea Tsamaiso ea American Thyroid Association le American Association of Clinical Endocrinologists. Boitšoaro ba Endocrine. Vol 17 No. 3 May / June 2011.
> Braverman, L, Cooper D. Werner & Ingbar's The Thyroid, ea 10. WLL / Wolters Kluwer; 2012.
> Garber, J, Cobin, R, Gharib, H, et. al. "Litlhahiso tsa Bophelo ba Meriana ea Tlhahlobo ea Hystothyroidism ho Batho ba baholo: Lingoliloeng tsa American Association of Clinical Endocrinologists le American Thyroid Association li buuoa ka tsona." Boitšoaro ba Endocrine. Tsela ea 18: 6 November / December 2012.
> DSs DS. (2017). Tlhahlobo ea laboratabelo ea thyroid. Ka: UpToDate, Cooper DS (Ed), UpToDate, Waltham, MA.