Le hoja melatonin e le hormone eo boko bo hlahisang ka tlhaho, u ka 'na ua e tseba hamolemo e le pheko ea phekolo ea jet lag le liphapang tsa boroko. Bothata ba boko ba phaene bo boloka melatonin ka potoloho ea lihora tse 24. E boetse e hlahisoa letlalong, retina ea leihlo le mofu oa masapo.
Ka tlhaho, tlhahiso ea melatonin litlhōrōng tsa bosiu, 'me e thibetsoe ke khanya ea letsatsi.
Ha lefifi le hlaha maemong a eketsehileng a melatonin, ho tlisetsa ho tsitsa le ho khutsa-'me ka tšepo, ho robala. Lintho tse ling le li-hormone tse kang serotonin le tsona ke tsa bohlokoa ho laola tsela ea 'mele ea ho robala .
Boroko, Melatonin le Kankere
Liphuputso tse bontšang ho kopana pakeng tsa boroko bo sa lokelang, maemong a tlaase a melatonin le kankere li entse hore ho be le thahasello e kholo. Mosebetsi oa bosiu o amahanngoa le mokhathala le boroko, maemong a tlase a melatonin maling, le maloetse a mangata a fapaneng ho akarelletsa lefu la pelo, lefu la metabolic-le kankere ea mefuta e sa tšoaneng.
Kotsi ea Mosebetsi le Kankere
Lintho tsena kaofela li fumanoeng ho basebeletsi ba li-shift li ile tsa etsa hore bo-rasaense ba bang ba ipotse hore na melatonin e ka 'na ea thusa ho sireletsa batho ho tsoa maloetse ana. Phuputso e 'ngoe ea Canada ho banna ba sebetsang mosebetsing e ile ea fumana hore mosebetsi oa bosiu o amahanngoa le mefuta e mengata ea lik'hemik'hale tse sa tšoaneng, ho kopanyelletsa le bao e seng Hodgkin lymphoma .
Liphuputso tsa mofuta ona li sheba ho bona hore na ntho e tloaelehileng e amana le ntho e 'ngoe-e "tšoaetsanoang," kapa ho thoeng ke lefu la seoa.
Boitsebiso bo tsoang lipatlisisong tse tšoanang bo bonahala bo bontša hore ho ka etsahala hore melatonin e be teng le ho sithabela ho tšoaroa ke kankere ea matsoele . Basali ba sebetsang bosiu ba na le karolo ea 19 ho isa ho 51 ho eketsa kotsi ea kankere ea matsoele. Mabapi le kankere ea prostate , phuputso e 'ngoe e fumane hore banna ba nang le kankere ea prostate ba na le melumo e tlaase ea melatonin ha bapisoa le banna ba neng ba e-na le kankere empa e ka' na ea e-ba tšitiso ea ho robala, benign prostatic hyperplasia.
Ha ho le tse ling tsa lithuto tsena ke mofuta o ka bonang sesosa le phello, leha ho le joalo. Liphuputso li fana ka lithuto tse eketsehileng, empa ha li tšehe tšebeliso ea melatonin ho thibela kankere.
Ditshebeletso tsa liphoofolo le tsa laboratory
Liphuputso tsa laboratori li bontša hore melatonin ke antioxidant e matla e susumetsang likarolo tse itseng tsa tsamaiso ea 'mele ea ho itšireletsa mafung, empa ha e tsejoe haeba phello ena e etsahala ho batho. Melatonin e bonahala e thibela lik'hemik'hale tse ling tsa kankere hore li se ke tsa hōla ha li sebelisoa ka ho toba ho lisele tsena lijong tsa laboratori le lithutong tsa liphoofolo-phello ena e bonoa kankere ea matsoele le melanoma.
Liphuputso ho batho, leha ho le joalo, ha li fane ka maikutlo a hore na ho na le phello efe ea likokoana-hloko.
E thehiloe boitsebisong ba in vitro, bo-rasaense ba bang ba 'nile ba nahana hore ho tsosolosa ha' mele ea ho itšireletsa mafung, haeba ho teng ka har'a vivo, ho ka 'na ha se ke ha e-ba ntho e ntle maemong' ohle. Ka mohlala, mofuta o fosahetseng oa ho itšireletsa mafung ho bakuli ba tšoeroeng ke kankere ea mali kapa lymphoma e ka 'na ea e-ba e sa hlahiseng litholoana, kaha lik'hemik'hale tsena li akarelletsa ho bolaoa ha lisele tsa' mele tsa masole a 'mele ho lymph system, bone ea bone le mali.
Melatonin ka mehlala ea liteko e bonts'a matlotlo a mang a khahlanong le kankere, 'me ho tsosolosoa ha sesole sa' mele ho nahanoa hore ho ameha. Phuputso ea Miller e ile ea fana ka tlhahiso ea hore melatonin e kenye letsoho ho ts'ebetsong ha lymphocyte le monocyte / macrophages-mefuta e sa tšoaneng ea lisele tse tšoeu tsa mali.
Lymphomas ke kankere e hlahang ho lymphocytes.
In vitro, melatonin e bonahala eka e sebetsa ka sekhahla se bolaeang sa tlhaho sa T-cell , se susumetsa li-cell phone tse itseng tse bitsoang cytokines; e ka boela ea sireletsa li-precursors tsa sele ea mali ho tsoa kotsi e kotsi ea chemotherapy le radiotherapy , ho ea ka phuputso ea 2001 ea Maestroni.
Hape, ha ho tsejoe hore na melatonine e tla ba le phello efe ka vivo, ho bakuli ba sebele.
Melatonin ka kankere ea kankere
Ho honyenyane ho tsejoa ka melatonin ha e sebelisoa ho batho ba nang le kankere. Sehlopha se seng sa bo-rasaense se hlophisitse liphello tsa melatonin ha li fanoa hammoho le chemotherapy, radiotherapy, tlhokomelo e tšehetsang le tlhokomelo ea palliative ho bakuli ba nang le li-tumor tse matla - eseng le leememia kapa lymphoma.
Phuputsong ena, melatonin e ne e sa amahanngoa le chefo e eketsehileng kapa e fokotsoe ka katleho ea phekolo, 'me ho bonahala e thusa ka lik'hemik'hale tse ling tsa lik'hemik'hale.
Melatonin ka bakuli ba kankere ea mali
Esita le tse ling tse tsejoang ha ho tluoa tabeng ea melatonin ho batho ba nang le kankere ea mali joaloka leukemia le lymphoma . Mekhoa ea hona joale ea National Comprehensive Cancer Network (NCCN) ea li-lymphomas tse seng tsa Hodgkin, mofuta o tloaelehileng ka ho fetisisa oa lymphoma, ha li akarelletse litlhahiso mabapi le tšebeliso ea melatonin.
Bongata ba lipatlisiso tse hatisitsoeng hona joale ka melatonin, ka tsela leha e le efe e amanang le lymphoma li bonahala li tsoa litabeng tsa in vitro le liphoofolo, eseng liteko tsa kliniki.
Kamehla buisana le ngaka ea hau mabapi le ho nka liphallelo tse ling, kaha li-supplement li ka ba le liphello tse bohloko le likamano tsa lithethefatsi.
Lentsoe ho:
Melatonin e 'nile ea sebelisoa ka mokhoa o sireletsehileng e le ho thusa batho ba bangata ho robala,' me e na le karolo ea bohlokoa ea ho phekoloa ha litšitiso tse sa tšoaneng tsa boroko.
Melatonin ke sehlahisoa sa tlhaho, empa lihlahisoa tsa tlhaho li ntse li ka ba le litla-morao le likamano tse sa lebelloang. Melatonin e ka sebelisana le mefuta e sa tšoaneng ea meriana, ho kenyelletsana le li-sedative, li-anti-depressants, meriana ea li-hormone le tse ling.
Bua le ngaka ea hau ka tšebeliso ea hau ea melatonin kapa motsoako ofe kapa ofe-haholo-holo haeba u ntse u phekoloa ka kankere kapa ho kula leha e le efe e sa foleng.
Lisebelisoa
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SD ea Paredes, Rancan L, Kireev R, et al. Melatonin Likarabo ka Palo ea Phetolelo ea Tšebetso ea Ts'oaetso le ea Apoptotic Sekhahla ho Ischemic Brain Kotsi e bakoang ke Bohareng ba Cerebral Artery Blockade lilemong tsa Maqheku. BioResearch Open Access . 2015; 4 (1): 407-416.
Likhoeletso tsa NCCN ho Lina-mali tse se nang Hodgkin. Version 1.2016. E fihlile ka February 2016.