Ntho ea P e na le liphello tse senyang likokoana-hloko
Mokhoa oa P o ne o khetholloa joang
Ntho ea pele P e ile ea fumanoa ka 1931, empa bohlokoa ba eona 'meleng bo nka lilemo tse mashome hore e senyehe. Lilemong tsa bo-1950, ho ne ho etsoe qeto ea hore motsoako oa P e ne e le mothapo oa mali. Lisele tsa masapo li buisana ka li-neurotransmitters. Ntho ea P e fumanoe e sebetsana le ho fetisa bohloko ba lenaka la dorsal. Lenaka la masene le entsoe ka li-neurons tse utloahalang 'me le fumanoa ka litekanyetso tsohle tsa mokokotlo oa mokokotlo.
Lilemong tsa bo-1970, thepa ea likokoana-hloko ea P e ile ea senoloa. Ntho ea P e ile ea khetholloa e le protheine e nang le likarolo tsa amino acid.
Karolo ea ntho P ka 'Meleng
Lipatlisiso tse ngata tsa liphoofolo le tsa in vitro li ne li khannoa e le hore karolo ea motsoako oa 'mele' meleng e utloisisoe hantle. Bafuputsi ba fumane hore motsoako oa P o baka bohloko ka mokhoa o tsejoang e le nociception. Nociceptor ke lisele tse nang le mocheso kapa masapo a methapo a sebetsanang le tšusumetso e ka lematsang ka ho bontša mokokotlo oa mokokotlo le boko. Ho se khetholle ho etsa hore maikutlo a bohloko a be teng. E ile ea boela ea fumanoa hore motsoako oa P o na le liphello tsa proinflammatory.
Sesebelisoa sa P le seholo sa eona se amohelehang, se-neurokinin-1 (NK-1) se fumanoang, se teng li-neurons tse fumanehang hohle ho neuroaxis (e leng leqhoa le fetang boko le mokokotlo). Li-neurons tseo li phetha karolo ea bohloko, khatello ea kelello le matšoenyeho. Sesebelisoa P se boetse se teng tsamaisong ea methapo ea methapo, ho akarelletsa hypothalamus le amygdala.
Libaka tsena li amana le boitšoaro ba maikutlo.
Ntle le ho lemoha bohloko, khatello le matšoenyeho, ntho ea P e boetse e fumanoe e phetha karolo ea likarabo tse ngata tsa physiologic:
- ho hlatsa
- boitšoaro bo itšireletsang
- fetola ka molumo oa pelo
- khothatso ea ho patala habonolo
- ho robala ha mesifa
- bohlasoa
Ntho ea P le Arthritis
Bafuputsi ba ithutile ho kenngoa ha motsoako P ka ramatiki le maloetse a chesang. Bakeng sa lithethefatsi P ho bapala karolo ea ramatiki, tsamaiso ea methapo e tlameha ho kenella ho pathophysiology ea ramatiki. Ho tlameha hore ho be le mongobo oa ho ba le methapo ea mantlha ho e kopanetsoeng . Liphuputso tse ling li fana ka maikutlo a joalo:
- Ntho ea P e fumanoe libakeng tse khethehileng tsa bohlokoa.
- Sesebelisoa P se teng ka mahlaseli a phahameng ho synovial fluid ea ramatiki ea ramatiki .
- Palo ea li-receptor tse nang le lithethefatsi li fapane le lisele tsa rheumatoid.
Levine et al. o ile a fana ka tlhahiso ea hore mekhoa e meholo ea li-neural e ka fana ka tlhaloso ea likarolo tse ling tse hlaheletseng tsa ramatiki ea lefu la rumatoid: manonyeletso a itseng a atisa ho hlahisa ramatiki; Lihlopha tse tobileng li hlahisa ramatiki e matla haholo; 'me mohlala oa manonyeletso a amehang ke ramatiki ea lefu la masapo ke a mabeli le a mabeli. Lotz et al. o ile a fumana karolo e 'ngoe e ka khonehang bakeng sa ntho e bitsoang P ka ramatiki. Lotz le sehlopha sa hae ba ile ba bontša hore ntho ea P e ka susumetsa li-synoviocytes (synovial cells) ka lefu la ramatiki. Mokhoa oa P o ile oa eketsa ho lokolloa ha prostaglandin le collagenase ho tloha synoviocytes.
Sepheo sa P.
Na lipatlisiso tsa karolo ea P-P li hlahisitse phekolo e ncha ea ramatiki?
Hase hantle. Empa, bafuputsi ba re ho na le monyetla oa ho hanyetsa mohanyetsi oa NK1 (blocker) hore a hlahisoe e le phekolo ea lefu la ramatiki. Khabareng:
- Li-glucocorticoids li ka fokotsa ho ruruha ho tsoang meleng ea methapo ka ho fokotsa polelo ea NK-1, ha ho ntse ho eketsa tlhahiso ea enzyme e bakang ho senyeha ha ntho P.
- Tlhapi ea capsaicine e ka sehloohong e ka felisa ntho ea P ho tloha moo ho etsoang methapo ea pelo ho fokotsa bohloko. Ho ea ka rheumatologist, Scott J. Zashin, MD, capsaicin a ka nka libeke tse 1 ho isa ho tse 4 ho sebetsa. E le ho boloka melemo ea phomolo ea bohloko, capsaicin e tlameha ho sebelisoa hape ho latela litaelo.
Karolo ea Mesebetsi P ka Bohloko bo Botle Ka mor'a ho Buuoa
Tlhahisoleseding mabapi le karolo ea motlakase P ka ho hlaphoheloa ha bohloko habonolo ka mor'a ho buuoa ho bakuli ba nang le boemo bo sa foleng ba ho ruruha ho batla ho haella, joalo ka tsebo e amanang le kamano pakeng tsa liphetoho tsa boemo ba P le bohloko bo boholo. Ho ea ka PLoS One (2016), bafuputsi ba ile ba hlahloba kamano pakeng tsa liphetoho tsa boemo ba P le ho ba le bohloko bo matla ho bakuli ba nang le ramatiki ea lefu la masapo ba ileng ba etsoa opereishene ea meriana. Ba fumane hore maqhama pakeng tsa bohloko bo matla ba 'mele le motsoako oa serame oa serumone o etsahetse ka mor'a moo ho bakuli ba nang le ramatiki ea mali, empa e ne e sa fumanoe ka metsi a metsi.
> Mehloli:
> Garret NE et al. Karolo ea ntho P ka ramatiki ea ho ruruha . Annals ea Rheumatic Diseases 1992; 51: 1014-1018.
> Keeble le Brain. Karolo ea Tlhaho P ka Ramatiki? Litlhaku tsa Neuroscience. Buka ea 361. Litaba tsa 1-3, la 6 Mphalane 2004. Maqephe 176-179
> Levine JD, Mokokotlo DH, Basbo AI, Moskowitz MA, Helms CA. Hypothesis: tsamaiso ea methapo e ka tlatsetsa ho pathophysiology ea ramatiki ea ramatiki. Journal ea Rheumatology. 1985, 12 (3): 406-411.
> Lisowska, B. et al. Mokhoa oa P le Mahlaba a Bohlokoa Bakuli ba Phelang ka ho Buuoa. PLoS One. 2016 Jan 5; 11 (1): e0146400. doi: 10.1371 / koranta.pone.0146400.
> Lotz M, Carson DA, Vaughan JH. Mokhoa oa ho sebetsa ha synoviocytes ea lefu la ho ruruha: tsela ea neural in pathogenesis ea ramatiki. Saense. 1987 Feb 20; 235 (4791): 893-5.
> O'Connor T et al. Karolo ea Mesebetsi P ka mafu a ho ruruha. Journal of Cell Physiology. 2004 Nov; 201 (2) 167-80.