Hang ha Phekolo e Tloaelehileng ea Ramatiki ea Rheumatoid
Nakong e fetileng, phekolo ea khauta e ne e le kalafo e tloaelehileng bakeng sa ho sebetsa ka matla. Ho ile ha sebelisoa metsoako ea khauta ho phekola ramatiki ea lefuba ho tloha ka 1929. Khauta e ne e hlile e hlahisoa e le phekolo ea lefuba. Ka nako eo, ka phoso e ne e nahana hore lefu la masapo le lefu la masapo le ne le amana le maemo. Le hoja seo se ne se sa nepahala, khauta e ile ea bontša phello e ntle ho ramatiki ea lefu la rumatoid.
Kamoo e Sebetsang Kateng
Le hoja mochine oa phello ea khauta e khahlanong le ho ruruha ha o utloisisoe ka botlalo, bopaki bo bontša hore khauta e bolokiloe lysosomes e thibelang ho sebetsana le li-antigenic (ntho e 'ngoe le e' ngoe e susumetsang tlhahiso ea li-antibodies) le ho lokolloa ha li- cytokines tse bolaeang likokoana-hloko. Ka lebaka leo, e khetholloa e le lithethefatsi tse loantšang mafu-anti-rheumatic drug (DMARD) .
Ho fumaneha ha Gold
Mefuta ea li-parenteral tsa khauta e kenngoa 'me e akarelletsa Myoschrysine (lerothiomalate) le Solganol (lerothioglucose). Ridaura (auranofin) ke thepa ea khauta ea molomo. Ho theosa le lilemo, ha ho e-ba le phekolo e ncha e ileng ea e-ba teng e neng e fana ka phaello e phahameng le mocheso o fokolang (mohlala, li-DMARD tse ling le lithethefatsi tsa biologic ), liente tsa khauta li ne li atisa ho behoa bakeng sa ramatiki ea ramatiki. Tšebeliso ea eona e fokotsehile ka ho khetheha ka lebaka la kotsi ea litla-morao, hammoho le tlhokahalo ea ho hlahloba lik'hemik'hale le tsa laboratori e haufi, le ho senyeha ha ente ea 'mele.
Ho Laoloa ke Khauta Joang?
Li-shots tsa khauta li sebelisoa e le ente e entsoeng ka methapo ka nako ea beke beke le beke bakeng sa libeke tse 20 tsa pele tsa phekolo 'me joale lebelo le kenngoa libeke tse tharo kapa tse' nè. Palo ea mali le tlhahlobo ea moroto li khothaletsoa pele ho jeloa ka khauta, ho netefatsa hore ho bolokehile ho fana.
Qalong, ente e entsoeng ka methapo ea khauta e atisa ho tsamaisoa e le tekanyo e nyenyane ea limililo tse 10, hang ka beke. Lebelo la bobeli la limilione tse 25 le latela limiligrama tse 50 ka beke ho fihlela karabo e finyelloa, ho fihlela ho lilograma tse 750 ho isa ho 1000.
Liphello Tse Ntle Etsa Hore Phekolo ea Khauta e be e thata
Litla-morao, lebaka le tloaelehileng la ho thibela ho phekola ha khauta, le ama karolo ea 30 lekholong ea batho ba tšoaroang ka metsoako ea khauta ea parenteral. Litla-morao tse tloaelehileng tse amanang le khauta ea parenteral li akarelletsa pruritis, dermatitis, stomatitis, le proteinuria. Ka khauta ea molomo, likoti tse hlephileng ke phello e tloaelehileng ea litholoana, ha letšollo la metsi le hlaha hangata (le amang karolo ea 5 lekholong ea bakuli). Nephropathy le thrombocytopenia le tsona li ka hlahisa phekolo ea khauta, haholo-holo ho tse ntle bakeng sa liphatsa tsa HLA-DR3.
Le hoja litla-morao tse ka 'nang tsa e-ba tse fokolang ke phekolo ea khauta, ho tlameha ho hlokomeloe hore liente tsa khauta li behile batho ba nang le ramatiki ea lefu la tšoaetso e le ho fokotsa ka ho sa feleng. Setsebi sa Rheumatologist Scott J. Zashin, MD, se re, "Ka lebaka leo, haeba mokuli a arabela liente tsa khauta, hangata a tsoelapele. Ho emisa khauta ho bakuli bana ho ka etsa hore ho be le phetoho ea ramatiki e ka 'nang ea se ke ea arabela ho boela ho phekoloa ka khauta. "
Leha ho le joalo, kaha lithunya tsa khauta li ile tsa sebelisoa hampe 'me ha phekoloa meriana e mecha, lik'hamphani li khaotse ho etsa meriana. Le hoja ho ne ho e-na le liforomo tse peli tsa khauta ka nako e le 'ngoe (Solganol le Myochrysine), hona joale Myochrysine e fumaneha feela. Hangata, bakuli ba hlahisa maikutlo a bona, ho etsa hore ba khaotse ho khaotsa.
Khauta ea Molomo e Bapisoa le Khauta e Senyang
Ka bomalimabe, khauta ea molomo e hlahisitse liphello tse fokolang feela, kahoo e ne e sa laeloa ka mokhoa o sa tloaelehang. Ridaura, tlhahiso ea khauta ea molomo, e ka 'na ea e-ba teng, empa ha e sebelisoe hangata United States. Khauta ea molomo e ile ea bontšoa hore e sebetsa hantle ha e bapisoa le placebo.
E ne e nkoa e sebetsa hantle ho Plaquenil (hydroxychloroquine) le methotrexate , empa ka matla a mangata a chefo.
The Bottom Line
Khauta ke DMARD e seng e hōlile (lithethefatsi tse loantšang likokoana-hloko) tse nang le likarolo tse ling tse ncha, tse nkeloa sebaka ke DMARD tse ncha le lithethefatsi tsa biologic. Tšebeliso ea khauta ka bongata e boloketsoe bakuli ba sa arabeleng kapa ba sa khone ho mamella methotrexate, tse ling tsa DMARD tsa khale (tse kang Plaquenil le sulfasalazine ), kapa li-block block tsa TNF .
Lisebelisoa:
> Cush JJ, Weinblatt ME, Kavanaugh A. Ramatiki ea lefuba: lefu la pele le ho phekoloa . Bophirimela Islip, NY: Professional Communications; 2010.
> Klinkhoff A. Litla-morao tse kholo tsa phekolo ea khauta. E maemong. https://www.uptodate.com/contents/major-side-effects-of-gold-therapy.
> Klinkhoff A. Ho Sebelisoa ha Lik'hemik'hale tsa Khauta ka Rheumatic Diseases. E maemong. https://www.uptodate.com/contents/use-of-gold-compounds-in-rheumatic-diseases?source=see_link.