Technivie (ombitasvir + paritaprevir + ritonavir) ke tšoaetso e nepahetseng ea lithethefatsi e sebelisoang ho phekola tšoaetso e sa foleng ea hepatitis C (HCV) . Litho tse tharo tse kenyelletsang Technivie li boetse li koaletsoe ka har'a phekolo ea lipilisi tse peli tsa HCV, Viekira Pak .
Technivie e ile ea amoheloa ka la 24 Phupu, 2015 ke US Food and Drug Administration (FDA) bakeng sa ho sebelisoa ho batho ba baholo lilemo tse 18 kapa ho feta ka tšoaetso ea HCV genotype 4 (GT4) ntle le boloetse .
Technivie ke phekolo ea pele ea HCV ea mahala-oral, ea oral-interferon bakeng sa bakuli GT4 e sa foleng HCV tšoaetso, e leng sechaba seo ka tloaelo se nkoang se le thata ho se tšoara.
Technivie e ile ea tlalehoa hore e na le pheko ea 100% ea bakuli ba neng ba sa phekoloe ("naïve") nakong ea nyeoe ea Phase IIb e ileng ea etsoa ho tloha ka la 12 August, 2012 ho la 19 November, 2013.
Tekanyo
Matlapa a mabeli (12.5mg ombitasvir, 75mg paritaprevir, 50mg ritonavir) e nkiloe letsatsi le letsatsi ka lijo ntle le tlhokahalo e kholo ea mafura kapa caloric. Matlapa a Technivie a pinki, a oblong le a koahetsoeng ka filimi, a nang le "AV1" e khabisitsoeng ka lehlakoreng le leng.
Ho hlalosa Litlhahiso
Technivie e laeloa ho feta koetliso ea libeke tse 12 hammoho le ribavirin (sethethefatsi se sebelisetsoang ho thibela kokoana-hloko ea RNA synthesis). Lebelo le khothalletsoang la ribavirin le thehiloe boima, ka tsela e latelang:
- Ka tlase ho li-165 lbs (75kg): 1000mg letsatsi le leng le le leng, e arotsoe le ho tsamaisoa habeli ka letsatsi le lijo
- 165 lbs (75kg) le ho feta: 1250mg letsatsi le leng le le leng, o arotsoe le ho laoloa habeli ka letsatsi le lijo
Koetliso ea libeke tse 12 tsa Technivie e ka nkoa e le kalafo ea mokuli ea sa khoneng ho mamella ribavirin.
Liphello tse Tloaelehileng
Litla-morao tse tloaelehileng tse amanang le tšebeliso ea Technivie (e hlahang bonyane bakuli ba 7%) ke:
- Bofokoli ba 'mele
- Mokhathala
- Nausea
- Ho tsieleha
- Rash
Meriana e kopanetsoeng
Lithethefatsi tse latelang ha lia lokela ho nkoa ha li sebelisoa Technivie:
- Li-Anticonvulsants: Tegretol, Dilantin, Trileptal, phenobarbital
- Antipsychotics: Orap
- Meriana ea li-antiretroviral: Sustiva
- Cholesterol-ho theola lithethefatsi tsa statin: Altoprev, Mevacor, Zocor
- Meriana ea ho se sebetse ka Erectile: Revatio
- Lihlahisoa tsa Ergot (tse sebelisetsoang ho phekola hlooho): DHE 45, Ergomar, Ergotrate, Hydergine, Migranal
- Mekhoa ea thibelo ea thibelo ea li-Estinyl estradiol: Estinyl, Apri, Reclipsen, Azurette, Kariva, Yaz, Yasmin, Ocella, Vestura, Beyaz, Safyral, Zovia, Demulen, Demulen 1/35, Kelnor 1/35, Nuva Ring, FaLessa, Luther , Seasonique, Aviane, Ortho Evra, Xulane, Lo Loestrin Fe, Necon 1/35, Minastrin 24 Fe, Loestrin 24 Fe, Ortho Tri-Cyclen, Sprintec, Ortho Tri-Cyclen Lo, Tri-Sprintec, Cryselle, Lo / Ovral, Ovral, Elinest
- Meriana e thibelang lefuba ea Rifampin: Mycobutin, Rifater, Rifamate, Rimactane, Rifadin, Priftin
- Litloaelo: Ho latela, Halcion
- Mokhoakho oa St. John's
Litlhaloso le likhokahano
Tlhahiso ea Technivie ha e khothalletsoe ho bakuli ba nang le bokooa bo itekanetseng ba bokooa (Palo ea Bana-Pugh B) 'me e hanyetsanoa le bakuli ba nang le bokooa bo matla bo feteletseng (Palo ea Bana-Pugh C).
Technivie e hanana le ho sebelisoa ho bakuli ba nang le hypersensitivity tse tsebahalang ho ritonavir (e leng, ba ileng ba bona Stevens-Johnson Syndrome kapa lefu la epidermal necrolysis).
Le hoja Technivie ka boeona e sa lumellane le ho sebelisoa nakong ea bokhachane, motsoako oa Technivie le ribavirin ke 'me ha oa lokela ho sebelisoa ho basali ba immeli kapa banna bao basali ba bona ba nang le bona ba imme. Mabapi le ho anyesa, ho ne ho se na likotsi tsa tlhaho e sa tloaelehang ea nts'etsopele ea lithuto tsa liphoofolo; Ho buisanoa ka litsebi tsa litsebi ho buisana ka melemo e meng le liphello tse mpe tsa ho anyesa ha a ntse a le Technivie.
Mohloli:
US Administration of Drug and Drug Administration (FDA). "FDA e amohela Technivie bakeng sa phekolo ea mofuta o sa foleng oa lefu la sebete la hepatitis C 4." Silver Spring, Maryland; tokomane ea khatiso e fanoeng ka la 24 July, 2015.
Hézode, C .; Asselah, T .; Reddy, R .; et al. "Ombitasvir hammoho le paritaprevir hammoho le ritonavir e nang le kapa ntle le ribavirin bathong ba nang le phihlelo ea ho phekola kalafo le ea kalafo e nang le tšoaetso ea kokoana-hloko e sa foleng ea hepatitis C (PEARL-I). Lancet. La 20 June, 2015; 384 (9986): 2502-2509.